Multichannel pipetting head

Patent metadata

Field	Value
Publication number	US-12290805-B2
Application number	US-202117366146-A
Country	US
Kind code	B2
Filing date	Jul 2, 2021
Priority date	Jul 2, 2020
Publication date	May 6, 2025
Grant date	May 6, 2025

Abstract

A multichannel pipetting head comprises a plunger actuator comprising at least one groove with an upper border, and a lower border. A plurality of plunger-cylinder units, wherein each plunger-cylinder unit comprises a cylinder and a plunger comprising a plunger head. The plunger head comprises a projecting upper abutment region adjoining the upper border, a projecting lower abutment region adjoining the lower border and laterally offset relative to the projecting upper abutment region, a plurality of guides. Each of the cylinders is coupled to a neck and held on each of the plurality of guides. During lateral movement of the plurality of guides, the plunger head is configured to tilt in the groove and to be held with the upper abutment region abutting the upper border and with the lower abutment region abutting the lower border of the groove due to restoring forces that occur during tilting in the plunger-cylinder units.

First claim

The invention claimed is:

1. A multichannel pipetting head comprising:
a horizontal plunger actuator comprising at least one groove, the at least one groove comprising an upper border, a lower border, and defining a side opening;
a drive rod configured to move the horizontal plunger actuator in a vertical direction;
a plurality of plunger-cylinder units, wherein each plunger-cylinder unit comprises,
a hollow cylinder, and
a plunger comprising a plunger head, the plunger head comprising,
a projecting upper abutment region adjoining the upper border of the horizontal plunger actuator;
a projecting lower abutment region adjoining the lower border of the horizontal plunger actuator and laterally offset relative to the projecting upper abutment region, wherein the plunger is configured to engage the hollow cylinder and is sealed off from the hollow cylinder and wherein the plunger head engages the groove through the opening; and

a plurality of guides configured to be shifted along a horizontal shaft, wherein each of the hollow cylinders is coupled to a neck and is held on each of the plurality of guides,
wherein during a lateral movement of the plurality of guides along the horizontal shaft, the plunger head is configured to tilt in the groove and is configured to be held with the upper abutment region abutting the upper border and with the lower abutment region abutting the lower border of the groove due to restoring forces that occur during tilting in the plunger-cylinder units.

2. The multichannel pipetting head according to claim 1 , wherein when the plunger-cylinder unit is comprised of a rigid material, the plunger head and the groove are configured to form an interference fit.

3. The multichannel pipetting head according to claim 1 , wherein at least one of: (1) the projecting upper abutment region of the plunger head is an upper abutment point on a top side; and (2) the projecting lower abutment region is a lower abutment area on a bottom side.

4. The multichannel pipetting head according to claim 3 , wherein at least one of: (1) the upper abutment point is positioned on a spherical cap on the top side; and (2) the lower abutment area is positioned on a lower edge of a downwardly pointing cylinder.

5. The multichannel pipetting head according to claim 1 , wherein the plurality of guides are rotatably mounted on the horizontal shaft.

6. The multichannel pipetting head according to claim 3 , wherein lower abutment areas are laterally offset further from the horizontal shaft than the upper abutment points.

7. The multichannel pipetting head according to claim 1 , wherein the upper border is opposite the lower border that projects further in a horizontal direction from one side, wherein the one side defines the opening.

8. The multichannel pipetting head according to claim 1 , comprising a resilient packing clamped to a top of each cylinder through which a plunger rod connected to the plunger is guided in an upwardly sealing manner.

9. The multichannel pipetting head according to claim 1 , wherein each plunger comprises a circumferential resilient sealing element positioned on an outer circumference and configured to seal a plunger running surface on an inner side of the hollow cylinder.

10. The multichannel pipetting head according to claim 1 , wherein each neck is supported on the plurality of guides via a compression spring, wherein each neck is configured to be moved upward relative to the plurality of guides counter to the compression spring.

11. The multichannel pipetting head according to claim 1 , wherein each plunger comprises a plunger rod configured to resiliently bend outward.

12. The multichannel pipetting head according to claim 1 , wherein each of the plurality of guides is configured to be moved in a horizontal direction using a control mechanism.

Assignees

• Eppendorf Ag

Inventors

• Wilth Marc
• Link Holger

Classifications

• B01L3/0234

  Repeating pipettes, i.e. for dispensing multiple doses from a single charge · CPC title

• B01L3/0227

  Details of motor drive means (B01L3/0231, B01L3/0234 take precedence) · CPC title

• B01L2200/022

  Variable spacings · CPC title

• B01L3/0279 Primary

  co-operating with positive ejection means · CPC title

• B01L3/0217 Primary

  of the plunger pump type · CPC title