Agent delivery systems and methods of using the same

Patent metadata

Field	Value
Publication number	US-12290628-B2
Application number	US-202117210166-A
Country	US
Kind code	B2
Filing date	Mar 23, 2021
Priority date	Mar 24, 2020
Publication date	May 6, 2025
Grant date	May 6, 2025

Abstract

A medical device that includes a handle for conveying an agent having particles and a receiver having a first lumen defined by a first end and a second end. The receiver having an axis extending between the first end and the second end. The first end configured to receive the particles from the handle, and the second end in fluid communication with a second lumen having a cross-sectional dimension smaller than a cross-sectional dimension of the first lumen. Each of the cross-sectional dimensions of the first lumen and the second lumen is measured transverse to the axis. The second end is configured to receive the particles from the first end of the receiver. The second lumen is configured to control delivery of the agent to a delivery conduit in fluid communication with the second lumen based on sizes of the particles.

First claim

We claim:

1. A medical device comprising:
an agent including a plurality of particles of varying size;
a handle including an enclosure for storing the agent; and
a receiver having:
a primary lumen with a cross-sectional dimension,
a proximal end having a first cross-sectional dimension that is smaller than the cross-sectional dimension of the primary lumen, and
a distal end having a second cross-sectional dimension that is smaller than the cross-sectional dimension of the primary lumen and the first cross-sectional dimension of the proximal end, such that the cross-sectional dimension of the primary lumen that is disposed between the proximal end and the distal end is greater than each of the first cross-sectional dimension and the second cross-sectional dimension;

wherein the receiver has an axis extending between the proximal end and the distal end, the proximal end configured to receive all of the plurality of particles of varying size of the agent conveyed from the handle to the receiver, the distal end in fluid communication with an insertion portion including a lumen having a cross-sectional dimension smaller than the cross-sectional dimension of the primary lumen;
wherein each of the cross-sectional dimension of the primary lumen, the cross-sectional dimension of the lumen of the insertion portion, the first cross-sectional dimension of the proximal end, and the second cross-sectional dimension of the distal end, is measured transverse to the axis;
wherein the distal end is configured to receive the plurality of particles of varying size that are received inside the primary lumen from the proximal end of the receiver and allow only a first portion of the agent to exit the primary lumen and enter the lumen of the insertion portion based on a predefined particle size, such that a second portion of the agent including the particles having a size that exceeds the predefined particle size are inhibited by the distal end from exiting the primary lumen and entering the lumen of the insertion portion; and
wherein the primary lumen is configured to collect the particles having the size that exceeds the predefined particle size between the proximal end and the distal end such that the second portion of the agent remains suspended in the primary lumen, the lumen of the insertion portion is configured to deliver the first portion of the agent based on the sizes of the first portion of the particles received in the lumen of the insertion portion not exceeding the predefined particle size.

2. The medical device of claim 1 , wherein the handle includes a filter mechanism disposed within the enclosure, the filter mechanism is configured to inhibit at least a third portion of the agent from being conveyed to the receiver based on the size of the particles.

3. The medical device of claim 1 , wherein the proximal end includes a proximal lumen having the first cross-sectional dimension, measured transverse to the axis, smaller than the cross-sectional dimension of the primary lumen, and greater than the cross-sectional dimension of the lumen of the insertion portion.

4. The medical device of claim 1 , wherein the handle includes a filter mechanism disposed within the enclosure, the filter mechanism is configured to inhibit at least a third portion of the agent from being conveyed to the receiver based on the size of the particles.

5. The medical device of claim 3 , wherein the proximal lumen is defined by and extends through the proximal end, and the distal end includes a distal lumen having the second cross-sectional dimension such that the distal lumen is defined by and extends through the distal end.

6. The medical device of claim 5 , wherein a length along the axis of the primary lumen is greater than a length along the axis of each of the distal lumen and the proximal lumen.

7. The medical device of claim 1 , wherein the distal end of the receiver includes an interface adjacent the primary lumen that is configured to control delivery of the agent from the primary lumen to the lumen of the insertion portion based on the sizes of the particles.

8. The medical device of claim 7 , wherein the interface of the distal end is a planar surface extending transverse to the primary lumen, and defining an opening disposed along the planar surface that is in fluid communication with the lumen of the insertion portion.

9. The medical device of claim 7 , wherein the interface of the distal end is a tapered surface defining an opening that is in fluid communication with the lumen of the insertion portion.

10. The medical device of claim 1 , wherein the receiver is removably coupled to an exterior of the handle with the proximal end of the receiver coupled to a distal portion of the handle.

11. The medical device of claim 1 , wherein the receiver is configured to mix the agent in the primary lumen and separate the plurality of particles based on the sizes of the plurality of particles;
wherein the distal end of the receiver is configured to receive a particle of the particles in the lumen of the insertion portion when the size of the particle is equal to or less than the predefined particle size, and inhibit receipt of the particle in the lumen of the insertion portion when the size is greater than the predefined particle size such that the particle is deflected out of the distal end and returned into the primary lumen; and
wherein the receiver is configured to deposit the particle along a bottom surface of the primary lumen, forming a static layer such that the particle is retained inside the primary lumen.

12. The medical device of claim 1 , further including a plunger at least partially disposed within the enclosure, wherein the plunger is configured to move relative to the enclosure to move the agent within the enclosure.

13. The medical device of claim 12 , wherein the plunger is configured to deliver a pressurized medium into the enclosure to move the agent toward the distal end of the receiver.

14. The medical device of claim 12 , wherein the handle is coupled to the plunger, wherein the handle is configured to control movement of the plunger relative to the enclosure to control delivery of the agent from the enclosure to the receiver.

15. A medical device comprising:
an agent including a plurality of particles of varying size;
a handle for storing the agent; and
a receiver including:
a longitudinal axis;
a primary lumen extending parallel to the longitudinal axis and having a cross-sectional dimension;
a proximal end having a proximal lumen extending parallel to the longitudinal axis and having a first cross-sectional dimension; and
a distal end having a distal lumen extending parallel to the longitudinal axis and having a second cross-sectional dimension;

wherein the primary lumen is disposed between the proximal lumen and the distal lumen, and the cross-sectional dimension is greater than the first cross-sectional dimension and the second cross-sectional dimension;
wherein the proximal lumen is configured to receive all of the plurality of particles of varying size conveyed from the handle to the receiver, the primary lumen is configured to retain a first portion of the particles that have a first size that is greater than a predefined particle size, and the distal lumen is configured to deliver only a second portion of the particles that have a second size that is smaller than the predefined particle size; and
wherein the receiver is configured to suspend the first portion of the particles inside the primary lumen between the proximal lumen and the distal lumen as the second portion of the particles move through th

Assignees

• Boston Scient Scimed Inc

Inventors

• Nam Ra
• Soukalopoulos Tony
• Hubbard Jr Dennis Brian
• Suon Naroun

Classifications

• A61M2202/064

  Powder · CPC title

• A61M25/0023

  by the form of the lumen, e.g. cross-section, variable diameter · CPC title

• A61M5/31581

  performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle · CPC title

• A61M5/31511

  Piston or piston-rod constructions, e.g. connection of piston with piston-rod (A61M5/5066 takes precedence) · CPC title

• A61M5/3145

  Filters incorporated in syringes · CPC title