Method, facility and tank for the manufacture of a liquid acid concentrate used for hemodialysis machines

Patent metadata

Field	Value
Publication number	US-12290619-B2
Application number	US-202418645730-A
Country	US
Kind code	B2
Filing date	Apr 25, 2024
Priority date	Nov 21, 2016
Publication date	May 6, 2025
Grant date	May 6, 2025

Abstract

The invention relates to a method for manufacturing a liquid acid concentrate for hemodialysis machines, with the following steps. In a preliminary step a water source ( 120 ), an acid source ( 130 ), an electrolyte tank ( 140 ) containing a mixture of electrolytes in exactly the quantity needed for the manufacture of the liquid acid concentrate, and a sodium chloride source ( 150 ) are connected to a mixing tank ( 110 ). During Step a), the quantity of water needed for the manufacture of the batch of liquid acid concentrate is introduced into the mixing tank ( 110 ). At Step b), the quantity of acid needed for manufacture the liquid acid concentrate is introduced into the mixing tank ( 110 ), the solution is stirred until a homogeneous solution is obtained. Step c) is to repeat Sub-steps c1) and c2) until the electrolyte mixture contained in the electrolyte tank is completely dissolved. At Sub-step c1) part of the solution contained in the mixing tank ( 110 ) is transferred into the electrolyte tank ( 140 ) containing the electrolyte mixture, then at Sub-step c2) the solution contained in the electrolyte tank ( 140 ) is transferred into the mixing tank, leaving the still solid constituents in the electrolyte tank. At Step d) the quantity of sodium chloride needed to manufacture the liquid acid concentrate is introduced into the mixing tank ( 110 ). Finally, at Step e), the solution is stirred and recirculated by taking it from the bottom the mixing tank ( 110 ) and reintroducing it at the top of the mixing tank until a homogeneous liquid acid concentrate is obtained. Steps a) to d) can be performed in any order, Step a) preceding always Step c).

First claim

The invention claimed is:

1. An electrolyte tank comprising:
a bag containing a mixture of electrolytes comprising one or more of potassium, calcium, and magnesium in an exact quantity needed to manufacture a batch of liquid concentrate, the bag comprising a single bag line configured to allow both the transfer of a solution from a mixing tank into the electrolyte tank, as well as the transfer of the solution from the electrolyte tank into the mixing tank, wherein
the single bag line is equipped with a connector configured to connect with a withdrawal line or lines configured to transfer the solution from the mixing tank into the electrolyte tank and a return line configured to transfer the solution from the electrolyte tank into the mixing tank.

2. The electrolyte tank according to claim 1 , wherein the mixture of electrolytes further comprises a sugar in a quantity needed to manufacture the batch of liquid concentrate.

3. A facility for manufacturing a predetermined quantity of a batch of liquid concentrate for hemodialysis machines, the facility comprising:
a mixing tank;
a water source connected to the mixing tank via a water introduction line;
an electrolyte tank containing a mixture of electrolytes comprising one or more of potassium, calcium, and magnesium in an exact quantity needed to manufacture the batch of liquid concentrate;
a withdrawal line, a return line, and a recirculation line, wherein the withdrawal line and the return line are one and the same line, two different lines, or a combination of the same and different lines and the withdrawal line leads from the mixing tank to the electrolyte tank to transfer part of a solution from the mixing tank into the electrolyte tank and the return line leads from the electrolyte tank to the mixing tank to transfer the solution contained in the electrolyte tank into the mixing tank; and
at least one pump to convey the solution in the withdrawal line, the return line, and the recirculation line, wherein
the electrolyte tank is equipped with a single bag line allowing both transfer of the solution from the mixing tank into the electrolyte tank, as well as transfer of the solution from the electrolyte tank into the mixing tank, wherein the single bag line is equipped with a connector for connection to the withdrawal line used to transfer the solution from the mixing tank into the electrolyte tank and to the return line used to transfer the solution from the electrolyte tank into the mixing tank, and
the facility is configured to repeat a transfer sequence of the solution until the mixture of electrolytes contained in the electrolyte tank is completely dissolved, the transfer sequence comprising
a) transfer of part of the solution contained in the mixing tank into the electrolyte tank, and then
b) transfer of the solution contained in the electrolyte tank into the mixing tank, leaving solid constituents in the electrolyte tank.

4. The facility according to claim 3 , wherein the mixing tank is equipped with a scale configured to weigh one or more of: an amount of water introduced into the mixing tank; an amount of solution transferred from the mixing tank into the electrolyte tank; and an amount of solution transferred from the electrolyte tank into the mixing tank.

5. The facility according to claim 3 , wherein the mixing tank is equipped with a stirring means.

6. The facility according to claim 5 , wherein the stirring means is a stirrer with a mechanical drive.

7. The facility according to claim 3 , further comprising a density meter to measure the density of the solution.

8. The facility according to claim 3 , wherein
the water introduction line for introducing the water into the mixing tank, and/or the return line for transferring the solution contained in the electrolyte tank into the mixing tank open into a top of the mixing tank; and/or
an inlet of the withdrawal line for transferring part of the solution from the mixing tank to the electrolyte tank is located at a bottom of the mixing tank; and/or
an inlet of the recirculation line is located at the bottom of the mixing tank and an outlet of the recirculation line is located at the top of the mixing tank.

9. The facility according to claim 3 , further comprising a density meter in the recirculation line or in a bypass of the recirculation line, to measure density of the solution.

10. The facility according to claim 3 , wherein the batch is from 100 liters to 4,000 liters.

11. The facility according to claim 3 , wherein the batch is at least 100 liters.

12. The facility according to claim 3 , further comprising:
a buffer tank; and
a conveying line that leads from the mixing tank to the buffer tank, wherein
the conveying line is for transferring the batch of liquid concentrate from the mixing tank to the buffer tank.

13. A method for manufacturing a predetermined quantity of a batch of liquid concentrate for hemodialysis machines, the method comprising steps of:
a) connecting a mixing tank to a water source and an electrolyte tank containing a mixture of electrolytes comprising one or more of potassium, calcium, and magnesium in an exact quantity needed to manufacture the batch of liquid concentrate, wherein the electrolyte tank is equipped with a single bag line allowing both transfer of a solution from the mixing tank into the electrolyte tank, as well as transfer of the solution from the electrolyte tank into the mixing tank, the single bag line is equipped with a connector for connection to a withdrawal line used to transfer the solution from the mixing tank into the electrolyte tank and to a return line used to transfer the solution from the electrolyte tank into the mixing tank;
b) introducing a quantity of water needed for the manufacture of the batch of liquid concentrate into the mixing tank;
c) repeating sub-steps until the electrolyte mixture contained in the electrolyte tank is completely dissolved, the sub-steps comprising
i) transferring part of the solution contained in the mixing tank into the electrolyte tank via the single bag line, and then
ii) transferring the solution contained in the electrolyte tank into the mixing tank via the single bang line, leaving solid constituents in the electrolyte tank; and

d) recirculating the solution by extracting it from a point in the mixing tank and reintroducing it at another point until a homogeneous liquid concentrate is obtained.

14. The method according to claim 13 , wherein the quantity of water introduced into the mixing tank in step b) is determined by weighing.

15. The method according to claim 13 , wherein, during sub-steps i) and ii), the quantity of solution transferred from the mixing tank into the electrolyte tank is weighed, and/or the quantity of solution transferred from the electrolyte tank into the mixing tank is weighed.

16. The method according to claim 13 , wherein the solution contained in the mixing tank is stirred during all of steps c) to d) with stirring means.

17. The method according to claim 13 , wherein a density of the solution is measured during and/or at the end of step d) and compared with a control value, wherein the solution is kept recirculating in step d) until the density measured corresponds to the control value.

18. The method according to claim 13 , wherein
various constituents of the liquid concentrate are introduced at a top of the mixing tank; and/or
during sub-step i), the solution is taken from a bottom of the mixing tank and is reintroduced during sub-step ii) at the top of the mixing tank; and/or
during step d), the sol

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Eyrard Thierry
• Laffay Philippe
• Luaire Benoit

Classifications

• B01F23/511

  characterised by the composition of the liquids or solids · CPC title

• B01F23/56

  by introducing solids in liquids, e.g. dispersing or dissolving · CPC title

• B01F21/30

  Workflow diagrams or layout of plants, e.g. flow charts; Details of workflow diagrams or layout of plants, e.g. controlling means · CPC title

• B01F35/2134

  Density or solids or particle number · CPC title

• B01F35/2133

  Electrical conductivity or dielectric constant of the mixture · CPC title