Agent containing 4-phenylbutyrate, for preventing or treating presbyopia

Patent metadata

Field	Value
Publication number	US-12290497-B2
Application number	US-201917414286-A
Country	US
Kind code	B2
Filing date	Dec 17, 2019
Priority date	Dec 18, 2018
Publication date	May 6, 2025
Grant date	May 6, 2025

Abstract

The present disclosure provides an agent for treating or preventing eye diseases such as presbyopia, comprising, as an active ingredient, 4-phenylbutyric acid or an ester thereof, or a pharmaceutically acceptable salt thereof.

First claim

The invention claimed is:

1. A method for treating presbyopia, comprising administering to a subject in need thereof an effective amount of 4-phenylbutyric acid, or a pharmaceutically acceptable salt thereof.

2. The method according to claim 1 , wherein the 4-phenylbutyric acid, or a pharmaceutically acceptable salt thereof, is administered ophthalmically.

3. The method according to claim 1 , wherein the 4-phenylbutyric acid, or a pharmaceutically acceptable salt thereof, is administered as an eye drop or an eye ointment.

4. The method according to claim 3 , wherein the amount of 4-phenylbutyric acid, or a pharmaceutically acceptable salt thereof, comprised in the eye drop or the eye ointment is 0.00001 to 10% (w/v).

5. The method according to claim 1 , wherein the 4-phenylbutyric acid, or a pharmaceutically acceptable salt thereof, is 4-phenylbutyric acid or a sodium salt thereof.

6. The method according to claim 3 , wherein the eye drop or the eye ointment comprises water, and an additive selected from ethyl pyruvate, sodium dihydrogenphosphate monohydrate, disodium hydrogenphosphate, hydroxypropyl methylcellulose, NaCl, or a mixture thereof.

Assignees

• Santen Pharmaceutical Co Ltd

Inventors

• Kato Masatomo
• Oda Tomoko
• Nozaki Kensuke

Classifications

• A61K31/192 Primary

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61K9/0048

  Eye, e.g. artificial tears · CPC title

• A61P27/10

  for accommodation disorders, e.g. myopia · CPC title

• A61P27/02

  Ophthalmic agents · CPC title

• A61K47/14

  Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters · CPC title