Oxygen consumption and energy expenditure monitoring

Patent metadata

Field	Value
Publication number	US-12290350-B2
Application number	US-201816762456-A
Country	US
Kind code	B2
Filing date	Nov 9, 2018
Priority date	Nov 9, 2017
Publication date	May 6, 2025
Grant date	May 6, 2025

Abstract

A patient ventilation system and a computing device-implemented method determine oxygen consumption in a mechanically ventilated subject includes receiving a signal representing a total flow at an inspiratory outlet of a ventilator, calculating a transport delay time between inspiratory and expiratory gas sample points in a patient ventilation circuitry, transmitting a signal to an inlet selector valve to selectively open a fluid path between the inspiratory gas sample point and an oxygen sensor or between the expiratory gas sample point and the oxygen sensor, receiving data representing oxygen content and carbon dioxide content over a period of time, calculating oxygen consumption data over the period of time from the data representing the total flow, oxygen content and carbon dioxide content and from the transport delay time, and displaying the oxygen consumption data over the period of time.

First claim

What is claimed is:

1. A computing device-implemented method to determine oxygen consumption in a mechanically ventilated patient, the method comprising:
receiving a signal representing a total flow at an inspiratory outlet of a ventilator;
calculating a transport delay time between inspiratory and expiratory gas sample points in a patient ventilation circuitry;
transmitting a signal to an inlet selector valve to selectively open a fluid path between the inspiratory gas sample point and an oxygen sensor or between the expiratory gas sample point and the oxygen sensor, wherein
the inspiratory gas sample point is located in the fluid path of the patient ventilation system between the patient and a source of air and oxygen, and
the expiratory gas sample point is located in the fluid path of the patient ventilation system between the patient and a fluid outlet or a mixing chamber fluidly connected to the fluid outlet;

receiving data representing oxygen content and carbon dioxide content over a period of time;
calculating oxygen consumption data over the period of time from the data representing the total flow, oxygen content and carbon dioxide content and from the transport delay time; and
displaying the oxygen consumption data over the period of time.

2. The method of claim 1 , further comprising repeating the transmitting and receiving steps over an observation period longer than the period of time.

3. The method of claim 1 , wherein calculating oxygen consumption comprises calculating a number of whole breaths of a patient from the delay time.

4. The method of claim 1 , further comprising correcting the signal representing the total flow for viscosity dependence.

5. The method of claim 1 , further comprising calculating flow-weighted averages of the inspiratory oxygen content and carbon dioxide content.

6. The method of claim 1 , further comprising calculating a respiratory quotient of a patient.

7. The method of claim 1 , further comprising calculating carbon dioxide production of a patient.

8. The method of claim 1 , further comprising calculating energy expenditure of a patient.

9. The method of claim 1 , further comprising calculating a transport delay time between a Y-connector that is attachable to a patient and the expiratory gas sample point.

10. The method of claim 1 , wherein the patient is a neonate.

11. A computing device-implemented method of claim 1 , further comprising:
correcting the signal representing the flow for viscosity dependence;
calculating a further transport delay time between a Y-connector that is attachable to a patient and the expiratory gas sample point; and
calculating flow-weighted averages of the oxygen content and carbon dioxide content.

12. A patient ventilation system comprising:
a ventilation fluid circuit with a fluid path connected to sources of air and oxygen, a fluid outlet, and a Y-connector that is attachable to a patient;
a flowmeter located in the fluid path between the sources of air and oxygen and the Y-connector;
an inhalation fluid sampling line connected at an inhalation gas sample point of the fluid path located between the sources of air and oxygen and the Y-connector;
an exhalation fluid sampling line connected to an exhalation gas sample point of the fluid path located between the patient and the fluid outlet or a mixing chamber fluidly connected to the fluid outlet;
an oxygen sensor and a carbon dioxide sensor configured to measure an oxygen concentration and a carbon dioxide concentration of a gas passing along a sensing path through the sensor, wherein the sensing path is connected to the inhalation fluid sampling line and to the exhalation fluid sampling line;
a selector valve arranged to selectively connect either the inhalation fluid sampling line or the exhalation fluid sampling line to the sensing path; and
a computing device comprising a memory configured to store instructions and a processor to execute the instructions to perform operations comprising:
receiving a signal representing a total flow at an inspiratory outlet of a ventilator;
calculating a transport delay time between inhalation and exhalation gas sample points;
transmitting a signal to the selector valve to selectively connect either the inhalation fluid sampling line or the exhalation fluid sampling line to the sensing path;
receiving data representing oxygen content and carbon dioxide content over a period of time;
calculating oxygen consumption data over the period of time from the data representing the total flow, oxygen content and carbon dioxide content, and from the transport delay time; and
displaying the oxygen consumption data.

13. The system of claim 12 , wherein the inhalation fluid sampling line, the exhalation fluid sampling line, or both the inhalation fluid sampling line and the exhalation fluid sampling line, are water permeable gas tubes that equilibrate their contents to ambient humidity.

14. The system of claim 13 , wherein the computing device performs a further operation comprising calculating carbon dioxide production.

15. The system of claim 13 , wherein the computing device performs a further operation comprising calculating an energy expenditure of the patient.

16. The system of claim 12 , wherein a portion of the ventilation fluid circuit is inside a ventilator.

17. The system of claim 12 , wherein the computing device performs a further operation comprising calculating a respiratory quotient of the patient.

18. The system of claim 12 , wherein the oxygen sensor comprises a laser diode sensor and the carbon dioxide sensor is a nondispersive infra-red sensor.

19. A patient ventilation system comprising:
a ventilation fluid circuit with a fluid path connected to sources of air and oxygen, a fluid outlet, and a Y-connector that is attachable to a patient;
an inhalation fluid sampling line connected at an inhalation gas sample point of the fluid path located between the sources of air and oxygen and the Y-connector;
an exhalation fluid sampling line connected to an exhalation gas sample point of the fluid path located between the Y-connector and the fluid outlet or a mixing chamber fluidly connected to the fluid outlet;
an oxygen sensor and a carbon dioxide sensor configured to measure an oxygen concentration and a carbon dioxide concentration of a gas passing along a sensing path through the sensor, wherein the sensing path is connected to the inhalation fluid sampling line and to the exhalation fluid sampling line;
a selector valve arranged to selectively connect either the inhalation fluid sampling line or the exhalation fluid sampling line to the sensing path; and
a computing device comprising a memory configured to store instructions and a processor to execute the instructions to perform operations comprising:
receiving a signal representing a total flow at an inspiratory outlet of a ventilator;
correcting the signal representing the total flow for viscosity dependence;
calculating a transport delay time between inspiratory and expiratory gas sample points in the ventilation fluid circuit;
transmitting a signal to an inlet selector valve to selectively open a fluid path between the inspiratory gas sample point and an oxygen sensor or between the expiratory gas sample point and the oxygen sensor;
receiving data representing oxygen content and carbon dioxide content over a period of time;
calculating flow-weighted averages of the oxygen content and carbon dioxide content;
calculating oxygen consumption data over the period of time from the

Assignees

• Childrens Medical Center
• Cosmed Srl

Inventors

• Clemensen Peter
• Kheir John
• Polizzotti Brian
• Thomsen Arne Bo

Classifications

• G09B23/303

  specially adapted to simulate circulation of bodily fluids · CPC title

• A61M2240/00

  Specially adapted for neonatal use · CPC title

• A61M2230/432

  partial CO2 pressure (P-CO2) · CPC title

• A61M2205/52

  with memories providing a history of measured variating parameters of apparatus or patient · CPC title

• A61M2205/3306

  Optical measuring means · CPC title