Storage of information using mixtures of molecules

Patent metadata

Field	Value
Publication number	US-12288584-B2
Application number	US-202117214664-A
Country	US
Kind code	B2
Filing date	Mar 26, 2021
Priority date	Sep 28, 2018
Publication date	Apr 29, 2025
Grant date	Apr 29, 2025

Abstract

A machine-readable medium and methods of reading and writing same are disclosed. The machine-readable medium comprises a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules. The molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

First claim

What is claimed is:

1. A machine-readable medium comprising:
a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules,
wherein the molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position, and
further wherein each molecule in the collection is linked to the substrate at the respective addressable location.

2. The machine-readable medium of claim 1 , wherein each molecule of the set of unambiguously identifiable molecules is associated with a binary digit.

3. The machine-readable medium of claim 1 , wherein the numerical value has a radix and a predetermined number of positions.

4. The machine-readable medium of claim 3 , wherein the numerical value is a binary value having a predetermined number, N, of bits.

5. The machine-readable medium of claim 4 , wherein each collection encodes a bit string.

6. The machine-readable medium of claim 5 , wherein the bit string encodes an ASCII value.

7. The machine-readable medium of claim 1 , wherein each molecule in the set is identifiable by a physical property.

8. The machine-readable medium of claim 7 , wherein the physical property is a fluorescent emission wavelength.

9. The machine-readable medium of claim 8 , wherein each molecule in the set comprises a quantum dot.

10. The machine-readable medium of claim 9 , wherein at least one molecule in the set comprises lead sulfide, lead selenide, cadmium selenide, cadmium sulfide, cadmium telluride, indium arsenide, indium phosphide, zinc selenide, or zinc sulfide.

11. The machine-readable medium of claim 9 , wherein each molecule in the collection is linked to the substrate by an amide bond.

12. The machine-readable medium of claim 11 , wherein the substrate comprises an epoxy resin.

13. The machine-readable medium of claim 7 , wherein the physical property is a mass-to-charge ratio.

14. The machine-readable medium of claim 1 , wherein:
the numerical value is a binary value having 32 bits; and
the set of molecules comprises the oligopeptides represented by the following amino acid sequences: Ac-AK(me3)C, Ac-(abu)K(me3)C, Ac-VK(me3)C, Ac-GGK(me3)C (SEQ ID NO: 1), Ac-GVK(me3)C (SEQ ID NO: 2), Ac-GLK(me3)C (SEQ ID NO: 3), Ac-ALK(me3)C (SEQ ID NO: 4), Ac-GFK(me3)C (SEQ ID NO: 5), Ac-GVGK(me3)C (SEQ ID NO: 6), Ac-GLGK(me3)C (SEQ ID NO: 7), Ac-GAGGK(me3)C (SEQ ID NO: 8), Ac-GL (abu)K(me3)C (SEQ ID NO: 9), Ac-GFGK(me3)C (SEQ ID NO: 10), Ac-GRGK(me3)C (SEQ ID NO: 11), Ac-GPAGK(me3)C (SEQ ID NO: 12), Ac-AYGK(me3)C (SEQ ID NO: 13), Ac-GPFK(me3)C (SEQ ID NO: 14), Ac-GVVGK(me3)C (SEQ ID NO: 15), Ac-G(abu)FGK(me3)C (SEQ ID NO: 16), Ac-GVFGK(me3)C (SEQ ID NO: 17), Ac-GVYGK(me3)C (SEQ ID NO: 18), Ac-GARGGK(me3)C (SEQ ID NO: 19), Ac-GAVV (abu)K(me3)C (SEQ ID NO: 20), Ac-GFYGK(me3)C (SEQ ID NO: 21), Ac-GYYGK(me3)C (SEQ ID NO: 22), Ac-GYYAK(me3)C (SEQ ID NO: 23), Ac-GPYFK(me3)C (SEQ ID NO: 24), Ac-GRGFGK(me3)C (SEQ ID NO: 25), Ac-GYFGGK(me3)C (SEQ ID NO: 26), Ac-GYYGGK(me3)C (SEQ ID NO: 27), Ac-AYYGGK(me3)C (SEQ ID NO: 28), and Ac-GYY(abu)GK(me3)C (SEQ ID NO: 29), wherein each Ac is an acetyl and each Abu is a 2-aminobutyric acid.

Assignees

• Harvard College
• Univ Northwestern

Inventors

• Whitesides George M
• Cafferty Brian J
• Ten Alexei S
• Fink Michael J
• Preston Daniel J
• Mrksich Milan M
• Nagarkar Amit A

Classifications

• B82B3/009

  Characterizing nanostructures, i.e. measuring and identifying electrical or mechanical constants · CPC title

• B82B3/0047

  Bonding two or more elements · CPC title

• B82B3/0019

  without movable or flexible elements · CPC title

• B82B1/008

  Nanostructures not provided for in groups B82B1/001 - B82B1/007 · CPC title

• B01J2219/00605

  the compounds being directly bound or immobilised to solid supports · CPC title