Magnetic particle imaging device

Patent metadata

Field	Value
Publication number	US-12287388-B2
Application number	US-202017912042-A
Country	US
Kind code	B2
Filing date	Apr 16, 2020
Priority date	Apr 16, 2020
Publication date	Apr 29, 2025
Grant date	Apr 29, 2025

Abstract

A static magnetic field generator generates a non-magnetic field region. An AC magnetic field application instrument applies an AC magnetic field to the non-magnetic field region. A detection coil has an axis parallel to a direction of the AC magnetic field in order to detect a magnetization signal. A measuring instrument is connected to the detection coil. A resonance frequency variable device includes a capacitor connected in parallel to the detection coil in order to adjust a resonance frequency of the detection coil and the measuring instrument. A capacity of the capacitor is adjusted such that a resonance frequency of a closed circuit including the detection coil, the measuring instrument, and the resonance frequency variable device including the capacitor coincides with a frequency of a harmonic signal.

First claim

The invention claimed is:

1. A magnetic particle imaging device to image a distribution of a magnetic particle in an inspection object, the magnetic particle imaging device comprising:
a static magnetic field generator to generate a non-magnetic field region;
an alternating current (AC) magnetic field application instrument to apply an AC magnetic field to the non-magnetic field region; and
a magnetization distribution measuring instrument to measure a harmonic signal emitted from a magnetic particle in the non-magnetic field region,
wherein the magnetization distribution measuring instrument includes:
a detection coil having an axis parallel to a direction of the AC magnetic field in order to detect a magnetization signal;
a measuring instrument connected to the detection coil; and
a resonance frequency variable device including a capacitor connected in parallel to the detection coil in order to adjust a resonance frequency of the detection coil and the measuring instrument, and
a capacity of the capacitor is adjusted such that a resonance frequency of a closed circuit including the detection coil, the measuring instrument, and the resonance frequency variable device coincides with a frequency of the harmonic signal,
the measuring instrument includes:
a transfer coil to be energized with a current based on a magnetic signal generated from the inspection object, and to excite a magnetic field based on an energizing current; and
a magnetic measuring instrument to measure a magnetic field excited by the transfer coil, and
the closed circuit includes the detection coil, the transfer coil, and the resonance frequency variable device.

2. The magnetic particle imaging device according to claim 1 , wherein
the resonance frequency variable device includes:
a plurality of capacitors including the capacitor, the plurality of capacitors being connected in parallel with each other; and
a switching circuit to switch one of the plurality of capacitors to be connected to the detection coil, and
a capacity of each of the plurality of the capacitors is adjusted such that a resonance frequency of a closed circuit including the detection coil, the measuring instrument, and the one of the plurality of the capacitors coincides with a frequency of one of a plurality of harmonic signals.

3. The magnetic particle imaging device according to claim 1 , wherein both or any one of the detection coil and the transfer coil is a superconducting coil.

4. The magnetic particle imaging device according to claim 3 , wherein
the superconducting coil includes a superconductor and a cooler, and
the detection coil, the transfer coil, and the resonance frequency variable device are connected by a normal conducting cable.

5. The magnetic particle imaging device according to claim 4 , wherein
the superconducting coil includes a heater thermally connected to the superconducting coil, and
the heater heats only a predetermined portion of the superconducting coil to cause transition of only the predetermined portion to a normal conduction band.

6. The magnetic particle imaging device according to claim 3 , wherein
the superconducting coil includes a heater thermally connected to the superconducting coil, and
the heater heats only a predetermined portion of the superconducting coil to cause transition of only the predetermined portion to a normal conduction band.

7. The magnetic particle imaging device according to claim 1 , wherein the transfer coil is arranged in parallel with the capacitor in the resonance frequency variable device and in parallel with the detection coil.

8. The magnetic particle imaging device according to claim 1 , wherein the magnetic measuring instrument includes a flux gate sensor or a Magnetic Impedance (MI) effect element.

Assignees

• Mitsubishi Electric Corp

Inventors

• Nomura Kota
• KATAGIRI Kodai
• Matsuda Tetsuya
• Tonooka Shun
• Yamauchi Kazuki

Classifications

• G01R33/3815

  with superconducting coils, e.g. power supply therefor · CPC title

• G01R33/3804

  Additional hardware for cooling or heating of the magnet assembly, for housing a cooled or heated part of the magnet assembly or for temperature control of the magnet assembly · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• A61B5/0515

  Magnetic particle imaging · CPC title

• A61B2562/0223

  Magnetic field sensors · CPC title