Anthelmintic depsipeptide compounds
US-11382949-B2 · Jul 12, 2022 · US
Anthelmintic depsipeptide compounds
US12286455B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12286455-B2 |
| Application number | US-202016943114-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 30, 2020 |
| Priority date | May 20, 2015 |
| Publication date | Apr 29, 2025 |
| Grant date | Apr 29, 2025 |
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- Title
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- Abstract
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Abstract
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The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
First claim
Opening claim text (preview).
What is claimed is: 1. An anthelmintic cyclic depsipeptide compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein: R′, R″, R″′ and R″″ are each methyl; and R a , R b , R 1 , R 2 , R 3 , R 4 , Cy 1 and Cy 2 are shown in the table below: # R a /R b R 1 R 2 R 3 R 4 Cy 1 /Cy 2 2-15 CH 3 /CH 3 CH 2 —iPr CH 2 CMe 2 F CH 2 —iPr CH 2 —iPr Ph/Ph, 2-16 CH 3 /CH 3 CH 2 —iPr CH 2 —iPr CH 2 CMe 2 F CH 2 —iPr Ph/Ph, 2-18 CH 3 /CH 3 CH 2 CMe 2 F CH 2 —iPr CH 2 CMe 2 F CH 2 —iPr Ph/Ph, 2-20 CH 3 /CH 3 CH 2 —iPr CH 2 CMe 2 F CH 2 CMe 2 F CH 2 —iPr Ph/Ph, 3-18 CH 3 /CH 3 CH 2 CMe 2 F CH 2 —iPr CH 2 CMe 2 F CH 2 —iPr p-F-Ph/ p-F-Ph, 3-19 CH 3 /CH 3 CH 2 —iPr CH 2 CMe 2 F CH 2 —iPr CH 2 CMe 2 F p-F-Ph/ p-F-Ph, 3-20 CH 3 /CH 3 CH 2 —iPr CH 2 CMe 2 F CH 2 CMe 2 F CH 2 —iPr p-F-Ph/ p-F-Ph, 3-26 CH 3 /CH 3 CH 2 CMe 2 F CH 2 CMe 2 F CH 2 CMe 2 F CH 2 CMe 2 F p-F-Ph/ p-F-Ph, 3-31 CH 3 /CH 3 CH 2 —iPr CH 2 —iPr CH 2 CMe 2 F CH 2 CMe 2 F p-F-Ph/ p-F-Ph, 4-6 CH 3 /CH 3 CH 2 —iPr CH 2 —tBu CH 2 —iPr CH 2 —tBu p-CF 3 -Ph/ p-CF 3 -Ph, 4-7 CH 3 /CH 3 CH 2 —tBu CH 2 —iPr CH 2 —tBu CH 2 —iPr p-CF 3 -Ph/ p-CF 3 -Ph, 4-8 CH 3 /CH 3 CH 2 —iPr CH 2 —tBu CH 2 —tBu CH 2 —iPr p-CF 3 -Ph/ p-CF 3 -Ph, 4-18 CH 3 /CH 3 CH 2 CMe 2 F CH 2 —iPr CH 2 CMe 2 F CH 2 —iPr p-CF 3 -Ph/ p-CF 3 -Ph, 4-19 CH 3 /CH 3 CH 2 —iPr CH 2 CMe 2 F CH 2 —iPr CH 2 CMe 2 F p-CF 3 -Ph/ p-CF 3 -Ph, 4-20 CH 3 /CH 3 CH 2 —iPr CH 2 CMe 2 F CH 2 CMe 2 F CH 2 —iPr p-CF 3 -Ph/ p-CF 3 -Ph, 4-26 CH 3 /CH 3 CH 2 CMe 2 F CH 2 CMe 2 F CH 2 CMe 2 F CH 2 CMe 2 F p-CF 3 -Ph/ p-CF 3 -Ph, 4-31 CH 3 /CH 3 CH 2 —iPr CH 2 —iPr CH 2 CMe 2 F CH 2 CMe 2 F p-CF 3 -Ph/ p-CF 3 -Ph, 4-32 CH 3 /CH 3 CH 2 CMe 2 F CH 2 —tBu CH 2 CMe 2 F CH 2 —-tBu p-CF 3 -Ph/ p-CF 3 -Ph, 5-6 CH 3 /CH 3 CH 2 —iPr CH 2 —tBu CH 2 —iPr CH 2 —tBu p-OCF 3 -Ph/ p-OCF 3 -Ph,
Assignees
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Classifications
Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title
Cyclic peptides {, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C (A61K38/043 - A61K38/046 take precedence)} · CPC title
Depsipeptides; Derivatives thereof · CPC title
Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 · CPC title
- A01N43/72Primary
having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms · CPC title
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- What does patent US12286455B2 cover?
- The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and…
- Who is the assignee on this patent?
- Boehringer Ingelheim Animal Health Usa Inc
- What technology area does this patent fall under?
- Primary CPC classification A01N43/72. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 29 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).