Sterilizable pharmaceutical package for ophthalmic formulations
US-2020171244-A1 · Jun 4, 2020 · US
US12285930B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12285930-B2 |
| Application number | US-201917299704-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 6, 2019 |
| Priority date | Dec 7, 2018 |
| Publication date | Apr 29, 2025 |
| Grant date | Apr 29, 2025 |
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An ophthalmic solution container has an accommodation part in which an ophthalmic solution is accommodated, and the accommodation part is composed of a laminate having a layer containing a cyclic olefin interpolymer (copolymer) and a layer containing a polyethylene resin provided outside the layer containing the cyclic olefin interpolymer (copolymer). The thickness of the layer containing the cyclic olefin interpolymer (copolymer) is 50 μm to 1,000 μm, and the thickness of the laminate is 300 μm to 2,000 μm. According to the container, it is possible to minimize sorption (adsorption and absorption) of the ophthalmic solution, it is possible to improve moisture barrier properties and minimize evaporation, and it is also possible to reduce the squeeze strength.
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What is claimed is: 1. An ophthalmic solution container having an accommodation part in which an ophthalmic solution is accommodated, wherein the accommodation part is composed of a laminate having an innermost layer that does not contain a cyclic olefin interpolymer (copolymer) and contains a polyethylene resin, an intermediate layer containing a cyclic olefin interpolymer (copolymer) provided outside the innermost layer, and an outer layer containing a polyethylene resin provided outside the intermediate layer containing the cyclic olefin interpolymer (copolymer), wherein a thickness of the intermediate layer containing the cyclic olefin interpolymer (copolymer) is 50 μm to 1,000 μm, a thickness of the outer layer containing a polyethylene resin is 350 μm to 1,400 μm, a thickness of the innermost layer is 162 μm or less, and a thickness of the laminate is 500 μm to 2,000 μm. 2. The ophthalmic solution container according to claim 1 , wherein the thickness of the intermediate layer containing the cyclic olefin interpolymer (copolymer) is 69 μm to 181 μm, and the thickness of the outer layer containing a polyethylene resin is 359 μm to 480 μm. 3. The ophthalmic solution container according to claim 1 , wherein the ophthalmic solution container has a nozzle part for instilling an ophthalmic solution accommodated in the accommodation part. 4. The ophthalmic solution container according to any one of claim 1 , wherein the intermediate layer containing the cyclic olefin interpolymer (copolymer) contains at least one of a COP (a copolymer of different cyclic olefins) or a COC (a copolymer of a cyclic olefin and an acyclic olefin).
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