Heart failure monitor using gait information

Patent metadata

Field	Value
Publication number	US-12285241-B2
Application number	US-201916700462-A
Country	US
Kind code	B2
Filing date	Dec 2, 2019
Priority date	Dec 4, 2018
Publication date	Apr 29, 2025
Grant date	Apr 29, 2025

Abstract

Systems and methods for monitoring heart failure (HF) status in a patient are discussed. An exemplary system includes a gait analyzer circuit than can receive gait or balance information, and generate a gait feature such as gait speed or a gait pattern. The system includes a HF detector circuit that can detect patient HF status, or to predict patient risk of a future worsening heart failure (WHF) event, using the gait feature. In some examples, the system may trigger sensing physiologic information according to the detected gait, and detect patient HF status using the sensed physiologic information. The system can initiate or adjust a heart failure therapy according to the HF status or the WHF risk.

First claim

What is claimed is:

1. A system for monitoring heart failure (HF) status of a patient, the system comprising:
a gait analyzer circuit configured to receive gait or balance information of a patient during locomotion, to generate a first gait feature and a second gait feature different than the first gait feature using the received gait or balance information, and to generate a first trend of the first gait feature over time and a second trend of the second gait feature over time; and
a HF detector circuit configured to determine respective weight factors for the first and second gait features using the first and second trends, to automatically determine a HF risk of the patient using a weighted combination of the first and second gait features each weighted by the respective weight factors, and to provide an output of the automatically determined HF risk to a display for presentation to a user or to adjust or initiate a process of the system.

2. The system of claim 1 , comprising:
a motion sensor coupled to the gait analyzer circuit and configured to sense the gait or balance information of the patient; and
at least one physiologic sensor configured to sense physiologic information different from the gait or balance information,
wherein the HF detector circuit is configured to automatically determine the HE risk of the patient further using the sensed physiologic information.

3. The system of claim 2 , comprising an ambulatory device that includes the motion sensor, the gait analyzer circuit, and the HF detector circuit,
wherein the motion sensor includes at least one of:
an accelerometer;
a gyroscope;
a magnetometer;
an inclinometer;
a goniometer,
an electromagnetic tracking system;
a global positioning system sensor;
a force sensor;
a strain gauge sensor;
an electromyography sensor; or
a camera configured to record an image or video of patient motion.

4. The system of claim 2 , comprising an ambulatory device that includes the gait analyzer circuit and the HF detector circuit, wherein the motion sensor is incorporated in a mobile device communicatively coupled to the ambulatory device.

5. The system of claim 1 , wherein the first and second gait features each include at least one of:
velocity;
time to peak velocity;
stride length;
stride width;
swing time;
single limb support time;
double limb stance;
gait autonomy;
cadence;
foot-hip angle; or
trunk-pelvis rotation angle.

6. The system of claim 1 , wherein at least one of the first or the second gait feature includes a gait pattern indicative of a degree of continuity or an inter-limb coordination during locomotion.

7. The system of claim 1 , comprising a multi-axis accelerometer configured to sense body acceleration of the patient during locomotion, and wherein the gait analyzer circuit is configured to generate a multi-dimensional representation of the sensed body acceleration; and
the HF detector circuit is configured to automatically determine the HF risk using the generated multi-dimensional representation.

8. The system of claim 7 , wherein the multi-dimensional representation includes a three-dimensional (3D) contour representing body accelerations in three directions, and the HF detector circuit is configured to automatically determine the HF risk using a geometric feature taken from the 3D contour.

9. The system of claim 1 , wherein the gait analyzer circuit is configured to identify one or more gait phases within a gait cycle, and to generate the first or the second gait feature using the received gait or balance information during the identified one or more gait phases.

10. The system of claim 1 , wherein:
the gait analyzer circuit is configured to generate a composite trend using the first trend of the first gait feature and the second trend of the second gait feature; and
the HF detector circuit is configured to automatically determine the HF risk of the patient using the generated composite trend.

11. The system of claim 1 , comprising an implantable medical device (IMD) that includes one or more of the gait analyzer circuit or the HF detector circuit.

12. The system of claim 1 , wherein the HF detector circuit is configured to trigger one or more physiologic sensors to sense physiologic information in response to at least one of the first or the second generated gait feature satisfies a condition, and to automatically determine the HF risk further using the sensed physiologic information.

13. The system of claim 1 , comprising a therapy circuit configured to initiate or adjust a HF therapy in accordance with the determined HF risk.

14. A system for monitoring heart failure (HF) status of a patient, the system comprising:
a gait analyzer circuit configured to receive gait or balance information of a patient during locomotion, to generate a gait feature including a multi-dimensional representation of body acceleration during locomotion using the received gait or balance information; and
a HF detector circuit configured to automatically determine a HF risk of the patient using the generated multi-dimensional representation and to provide an output of the automatically determined HF risk to a display for presentation to a user or to adjust or initiate a process of the system.

15. The system of claim 14 , comprising a multi-axis accelerometer configured to sense body acceleration during locomotion, and wherein the gait analyzer circuit is configured to generate the multi-dimensional representation of body acceleration during locomotion.

16. The system of claim 14 , wherein the multi-dimensional representation includes a three-dimensional (3D) contour representing body accelerations in three directions, and the HF detector circuit is configured to automatically determine the HF risk using a geometric feature taken from the 3D contour.

17. The system of claim 16 , wherein the geometric feature includes at least one of:
a location of a centroid of the 3D contour;
a diameter of 3D contour; or
an area or a volume of the 3D contour.

18. The system of claim 14 , comprising a therapy circuit configured to initiate or adjust a HF therapy in accordance with the determined HF risk.

19. A system for monitoring heart failure (HF) status of a patient, the system comprising:
a gait analyzer circuit configured to receive gait or balance information of a patient during locomotion, to generate two or more gait features using the received gait or balance information, and to generate a composite gait trend over time using the two or more gait features; and
a HF detector circuit configured to automatically determine a HF risk of the patient using the generated composite gait trend and to provide an output of the automatically determined HF risk to a display for presentation to a user or to adjust or initiate a process of the system.

20. The system of claim 19 , wherein the HF detector circuit is configured to
trigger one or more physiologic sensors to sense physiologic information in response to at least one of the generated gait features satisfies a condition; and
automatically determine the HF risk further using the sensed physiologic information.

Assignees

• Cardiac Pacemakers Inc

Inventors

• Wen Gezheng
• Mi Bin
• An Qi
• Thakur Pramodsingh Hirasingh

Classifications

• A61B5/7275

  Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor · CPC title

• A61B2562/0223

  Magnetic field sensors · CPC title

• A61B2562/0219

  Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches · CPC title

• A61B5/0077

  Devices for viewing the surface of the body, e.g. camera, magnifying lens · CPC title

• A61B5/1128

  using image analysis (A61B5/1127 takes precedence) · CPC title