Lumen morphology and vascular resistance measurements data collection systems apparatus and methods

Patent metadata

Field	Value
Publication number	US-12285240-B2
Application number	US-202217968927-A
Country	US
Kind code	B2
Filing date	Oct 19, 2022
Priority date	Sep 23, 2009
Publication date	Apr 29, 2025
Grant date	Apr 29, 2025

Abstract

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

First claim

The invention claimed is:

1. A method, comprising:
receiving, by one or more processors, vessel data including image data;
generating, by the one or more processors based on the received vessel data, a 3D representation of a vessel;
generating, by the one or more processors based on the received vessel data, a pressure-based blood flow model;
determining, by the one or more processors based on the pressure-based blood flow model, a vascular resistance ratio (VRR) or fractional flow reserve (FFR) value for each point along the vessel;
providing for output, by the one or more processors based on the generated pressure-based blood flow model, an indication of the VRR or FRR value on or relative to the 3D representation of the vessel and a 2D graphical representation of the pressure-based blood flow model comprising the VRR or FRR value and a length or distance along the vessel, wherein the VRR or FRR value is represented by a first axis and the length or distance along the vessel is represented by a second axis; and
receiving, by the one or more processors, an input selecting a portion of the 2D graphical representation of the pressure-based blood flow model, wherein the input identifies a candidate region for treatment.

2. The method of claim 1 , wherein the candidate region for treatment corresponds to a candidate stent location.

3. The method of claim 2 , further comprising providing for output, by the one or more processors based on the candidate stent location, information relating to a simulation of stenting.

4. The method of claim 3 , further comprising altering, by the one or more processors based on the information relating to the simulation of stenting, at least one of an image of the vessel, the 3D representation of the vessel, or the 2D graphical representation of the pressure-based blood flow model.

5. The method of claim 1 , wherein the received input controls a position for a proximal location indicator or a distal location indicator on the at least one of the 3D representation of the vessel or the 2D graphical representation of the pressure-based blood flow model.

6. The method of claim 5 , wherein the proximal and distal location indicators define the candidate region for treatment.

7. The method of claim 1 , wherein the pressure-based blood flow model is a fractional flow reserve (FFR) model.

8. A system, comprising:
one or more processors, the one or more processors configured to:
receive vessel data including image data;
generate, based on the received vessel data, a 3D representation of a vessel;
generate, based on received the vessel data, a pressure-based blood flow model;
determine, based on the pressure-based blood flow model, a vascular resistance ratio (VRR) or fractional flow reserve (FFR) value for each point along the vessel;
provide for output, based on the generated pressure-based blood flow model, an indication of the VRR or FFR value on or relative to the 3D representation of the vessel and a 2D graphical representation of the pressure-based blood flow model comprising the VRR or FFR value and a length or distance along the vessel, wherein the VRR or FFR value is represented by a first axis and the length or distance along the vessel is represented by a second axis; and
receive an input selecting a portion of the 2D graphical representation of the pressure-based blow flow model, wherein the input identifies a candidate region for treatment.

9. The system of claim 8 , wherein the candidate region for treatment corresponds to a candidate stent location.

10. The system of claim 9 , wherein the one or more processors are further configured to provide for output, based on the candidate stent location, information relating to a simulation of stenting.

11. The system of claim 10 , wherein the one or more processors are further configured to alter, based on the information relating to a simulation of stenting, at least one of an image of the vessel, the 3D representation of the vessel, or the 2D graphical representation of the pressure-based blood flow model.

12. The system of claim 8 , wherein the received input controls a position for a proximal location indicator or a distal location indicator on the at least one of the 3D representation of the vessel or the 2D graphical representation of the pressure-based blood flow model.

13. The system of claim 12 , wherein the proximal and distal location indicators define the candidate region for treatment.

14. The system of claim 8 , wherein the pressure-based blood flow model is a fractional flow reserve (FFR) model.

15. A non-transitory computer-readable medium storing instructions, which when executed by one or more processors, cause the one or more processors to:
receive vessel data including image data;
generate, based on the received vessel data, a 3D representation of a vessel;
generate, based on received the vessel data, a pressure-based blood flow model;
determine, based on the pressure-based blood flow model, a vascular resistance ratio (VRR) or fractional flow reserve (FFR) value for each point along the vessel;
provide for output, based on the generated pressure-based blood flow model, an indication of the VRR or FFR value on or relative to the 3D representation of the vessel and a 2D graphical representation of the pressure-based blood flow model comprising the VRR or FFR value and a length or distance along the vessel, wherein the VRR or FFR value are is represented by a first axis and the length or distance along the vessel is represented by a second axis; and
receive an input selecting a portion of the 2D graphical representation of the pressure-based blow flow model, wherein the input identifies a candidate region for treatment.

16. The non-transitory computer-readable medium of claim 15 , wherein the candidate region for treatment corresponds to a candidate stent location.

17. The non-transitory computer-readable medium of claim 16 , wherein the one or more processors are further configured to provide for output, based on the candidate stent location, information relating to a simulation of stenting.

18. The method of claim 1 , further comprising updating, by the one or more processors based on the received input, at least one other representation of the blood vessel to include an indication of the region of interest.

19. The system of claim 8 , wherein the one or more processors are further configured to update, based on the received input, at least one other representation of the blood vessel to include an indication of the region of interest.

20. The non-transitory computer readable medium of claim 15 , wherein the one or more processors are further configured to update, based on the received input, at least one other representation of the blood vessel to include an indication of the region of interest.

Assignees

• Lightlab Imaging Inc

Inventors

• Schmitt Joseph M
• Friedman Joel M
• Petroff Christopher
• Elbasiony Amr

Classifications

• A61B5/0073

  by tomography, i.e. reconstruction of 3D images from 2D projections (A61B5/0066 takes precedence) · CPC title

• A61B5/0066

  Optical coherence imaging · CPC title

• A61B5/0084

  for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence) · CPC title

• A61B5/02007 Primary

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title