Atomic description of immune complex that causes heparin-induced thrombocytopenia
US-11435362-B2 · Sep 6, 2022 · US
Atomic description of immune complex that causes heparin-induced thrombocytopenia
US12282028B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12282028-B2 |
| Application number | US-202418420177-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 23, 2024 |
| Priority date | Nov 6, 2014 |
| Publication date | Apr 22, 2025 |
| Grant date | Apr 22, 2025 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods of treating or reducing the likelihood of HIT, treating angiogenesis, treating abnormal cell growth, or affecting coagulation pathologies that lead to thrombus formation, by administering such mutant proteins to a patient.
First claim
Opening claim text (preview).
What is claimed is: 1. A mutant platelet factor 4 (PF4) monomer comprising amino acids 9 to 70 of SEQ ID NO: 11 and having a Q9S substitution relative to the amino acid sequence of SEQ ID NO: 11. 2. The mutant PF4 monomer of claim 1 , further comprising a L11V substitution relative to the amino acid sequence of SEQ ID NO: 11. 3. The mutant PF4 monomer of claim 1 , further comprising a K50E substitution relative to SEQ ID NO: 11. 4. The mutant PF4 monomer of claim 1 , further comprising a L55R substitution relative to the amino acid sequence of SEQ ID NO: 11. 5. The mutant PF4 monomer of claim 1 , further comprising a L11V substitution and a L55R substitution relative to the amino acid sequence of SEQ ID NO: 11.
Assignees
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Classifications
Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC · CPC title
Chemokines, e.g. RANTES · CPC title
comprising antibodies · CPC title
against proteinaceous materials, e.g. enzymes, hormones, lymphokines · CPC title
Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis · CPC title
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- What does patent US12282028B2 cover?
- The present invention provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods…
- Who is the assignee on this patent?
- Univ Pennsylvania
- What technology area does this patent fall under?
- Primary CPC classification G01N33/6863. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).