Oligomers and oligomer conjugates
US-10767181-B2 · Sep 8, 2020 · US
Oligomers and oligomer conjugates
US12281307B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12281307-B2 |
| Application number | US-202318114626-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 27, 2023 |
| Priority date | May 15, 2014 |
| Publication date | Apr 22, 2025 |
| Grant date | Apr 22, 2025 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.
First claim
Opening claim text (preview).
The invention claimed is: 1. An oligomer conjugate suitable for use in the treatment of a viral disorder, wherein said oligomer conjugate comprises: a) at least one first oligomer region capable of modulating a target sequence of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component; wherein said first oligomer region is 10-20 nucleotides in length; wherein said carrier component is a asialoglycoprotein receptor (ASGP-R) targeting moiety or a cholesterol conjugate moiety; and wherein said target sequence comprises at least part of a gene or a mRNA encoding HBx (SEQ ID NO: 1) or HBsAg (SEQ ID NO: 2) or a naturally-occurring variant thereof.
Assignees
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Classifications
Special therapeutic applications · CPC title
having a combination of backbone and sugar modifications · CPC title
5-Methylcytosine · CPC title
having an additional ring, e.g. LNA, ENA · CPC title
Phosphorothioates · CPC title
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Frequently asked questions
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- What does patent US12281307B2 cover?
- The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.
- Who is the assignee on this patent?
- Hoffmann La Roche
- What technology area does this patent fall under?
- Primary CPC classification A61K31/713. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).