Detection chip and detection system

Patent metadata

Field	Value
Publication number	US-12280371-B2
Application number	US-202117609816-A
Country	US
Kind code	B2
Filing date	Jan 15, 2021
Priority date	Feb 11, 2020
Publication date	Apr 22, 2025
Grant date	Apr 22, 2025

Abstract

A detection chip and a detection system are provided. The detection chip includes a base substrate, a flow channel defining layer, and at least one driving electrode group. The at least one driving electrode group is on the base substrate, and the flow channel defining layer is on a side of the at least one driving electrode group away from the base substrate, the flow channel defining layer includes a flow channel structure, and the flow channel structure is configured to accommodate liquid; and each of the at least one driving electrode group includes a plurality of driving electrodes, and the plurality of driving electrodes are configured to contact the liquid and drive the liquid to move within the flow channel structure.

First claim

What is claimed is:

1. A detection chip, comprising: a base substrate, a flow channel defining layer, and at least one driving electrode group,
wherein the at least one driving electrode group is on the base substrate, and the flow channel defining layer is on a side of the at least one driving electrode group away from the base substrate;
the flow channel defining layer comprises a flow channel structure, and the flow channel structure is configured to accommodate liquid; and
each of the at least one driving electrode group comprises a plurality of driving electrodes, and the plurality of driving electrodes are configured to contact the liquid and drive the liquid to move within the flow channel structure,
the detection chip further comprises: a mixing region, a buffer region, and a detection region, which are arranged in sequence, wherein the flow channel defining layer is at least in the mixing region, the buffer region, and the detection region, the at least one driving electrode group is configured to drive the liquid to sequentially pass through the mixing region, the buffer region, and the detection region,
the flow channel structure comprises a first flow channel portion, a second flow channel portion, and a third flow channel portion which are sequentially connected; the first flow channel portion is in the mixing region and is configured to allow the liquid to be mixed with a reaction reagent in the first flow channel portion; the second flow channel portion is in the buffer region; and the third flow channel portion is in the detection region and is configured to allow to perform optical detection on the liquid at least one detection point in the third flow channel portion,
wherein a cross-sectional shape of the first flow channel portion on a plane parallel to the base substrate is a rhombus, and
a largest dimension of the first flow channel portion in a first direction is greater than a largest dimension of the second flow channel portion in the first direction and greater than a largest dimension of the third flow channel portion in the first direction, the first direction is perpendicular to an extending direction of the flow channel structure.

2. The detection chip according to claim 1 , wherein the plurality of driving electrodes in the each of the at least one driving electrode group comprise a first electrode and a second electrode, and
the first electrode and the second electrode form an interdigital electrode structure to transmit an alternating current signal.

3. The detection chip according to claim 2 , wherein the first electrode comprises a plurality of first comb-shaped teeth, the second electrode comprises a plurality of second comb-shaped teeth, and
first comb-shaped tooth of the plurality of first comb-shaped teeth and a second comb-shaped tooth of the plurality of second comb-shaped teeth are alternately arranged in an extending direction of the flow channel structure.

4. The detection chip according to claim 3 , wherein in the extending direction of the flow channel structure, a width of a first comb-shaped tooth is different from a width of a second comb-shaped tooth, so as to allow the first electrode and the second electrode to form an asymmetric interdigital electrode structure.

5. The detection chip according to claim 4 , wherein in the extending direction of the flow channel structure, the width of the first comb-shaped tooth is smaller than the width of the second comb-shaped tooth, and a distance between adjacent first comb-shaped teeth is greater than a distance between adjacent second comb-shaped teeth.

6. The detection chip according to claim 4 , wherein in the extending direction of the flow channel structure, the width of the first comb-shaped tooth is 2 μm to 20 μm, and the width of the second comb-shaped tooth is 10 μm to 100 μm.

7. The detection chip according to claim 2 , wherein a material of the first electrode and a material of the second electrode comprise an inert metal material.

8. The detection chip according to claim 1 , wherein an orthographic projection of the flow channel structure on the base substrate is within an orthographic projection of the plurality of driving electrodes on the base substrate in the first direction.

9. The detection chip according to claim 1 , wherein the at least one driving electrode group comprises a first driving electrode group, a second driving electrode group, and a third driving electrode group;
the first driving electrode group is in the mixing region, and a plurality of driving electrodes of the first driving electrode group are configured to drive the liquid to move in the mixing region;
the second driving electrode group is in the buffer region, and a plurality of driving electrodes of the second driving electrode group are configured to drive the liquid to move in the buffer region; and
the third driving electrode group is in the detection region, and a plurality of driving electrodes of the third driving electrode group are configured to drive the liquid to move in the detection region.

10. The detection chip according to claim 1 , further comprising a detection reagent,
wherein the detection reagent is provided at the at least one detection point.

11. The detection chip according to claim 1 , wherein the flow channel defining layer further comprises a sample inlet, and
the sample inlet is outside the mixing region, the buffer region, and the detection region, and is connected to the first flow channel portion in the mixing region.

12. The detection chip according to claim 1 , wherein the flow channel defining layer further comprises a liquid storage portion, and
the liquid storage portion is outside the mixing region, the buffer region, and the detection region and is connected to the third flow channel portion in the detection region.

13. The detection chip according to claim 1 , wherein the first flow channel portion, the second flow channel portion, and the third flow channel portion form a liquid movement channel, and the liquid movement channel enables the liquid to move along a movement path of a straight-line shape.

14. The detection chip according to claim 1 , further comprising a cover plate,
wherein the cover plate is on a side of the flow channel defining layer away from the at least one driving electrode group.

15. A detection system, comprising a detection chip, a control device, and a chip mounting structure,
wherein the detection chip comprises a base substrate, a flow channel defining layer, and at least one driving electrode group, the at least one driving electrode group is on the base substrate, the flow channel defining layer is on a side of the at least one driving electrode group away from the base substrate, the flow channel defining layer comprises a flow channel structure, the flow channel structure is configured to accommodate liquid, each of the at least one driving electrode group comprises a plurality of driving electrodes, and the plurality of driving electrodes are configured to contact the liquid and drive the liquid to move within the flow channel structure, the detection chip further comprises: a mixing region, a buffer region, and a detection region, which are arranged in sequence, wherein the flow channel defining layer is at least in the mixing region, the buffer region, and the detection region, the at least one driving electrode group is configured to drive the liquid to sequentially pass through the mixing region, the buffer region, and the detection region, the flow channel structure comprises a first flow channel portion, a second flow channel portion, and a third flow

Assignees

• Beijing Boe Health Tech Co Ltd
• Boe Technology Group Co Ltd

Inventors

• Cui Haochen
• Li Jing
• Hu Tao
• Hu Lijiao
• Yuan Chungen
• Shen Xiaohe

Classifications

• B01L2300/087

  Multiple sequential chambers · CPC title

• B01L2300/0867

  Multiple inlets and one sample wells, e.g. mixing, dilution · CPC title

• B01L2300/0819

  Microarrays; Biochips · CPC title

• B01L2300/0645

  Electrodes · CPC title

• B01L2200/16

  Reagents, handling or storing thereof · CPC title