Bench-top time of flight mass spectrometer

Patent metadata

Field	Value
Publication number	US-12278097-B2
Application number	US-202418650681-A
Country	US
Kind code	B2
Filing date	Apr 30, 2024
Priority date	May 31, 2018
Publication date	Apr 15, 2025
Grant date	Apr 15, 2025

Abstract

A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection. The mass spectrometer automatically determines whether configuration information is stored locally in respect of each one of the detected functional modules, and, for the or each one of the detected functional modules for which such information is found to be stored locally, automatically uses the information in configuring the mass spectrometer, and, for any detected functional module(s) for which such information is not found to be stored locally, automatically obtains configuration information for the detected functional module(s) from a remote server, and uses the information in configuring the mass spectrometer.

First claim

The invention claimed is:

1. A method of performing a start-up routine for a mass spectrometer, the start-up routine being performed automatically upon switching ON the mass spectrometer,
wherein the mass spectrometer comprises a mass analyser and ion optics for guiding ions from an ion source to the mass analyser in use;
wherein the start-up routine comprises, when a first set of one or more conditions is met, putting the mass spectrometer into a power save mode, wherein the power save mode is a mode in which voltage is supplied to one or more components of the mass analyser, and voltage is not supplied to one or more components of the ion optics between the ion source and the mass analyser.

2. The method of claim 1 , wherein the mass spectrometer is automatically switched to the power save mode before a pressure of a vacuum chamber housing the mass analyser has reached an operating level.

3. The method of claim 1 , comprising pumping a vacuum chamber housing the mass analyser to reduce the pressure therein before switching the spectrometer to the power save mode, and continuing to pump the vacuum chamber after switching to the power save mode.

4. The method of claim 1 , wherein the first set of one or more conditions includes a requirement that a pressure within a vacuum chamber housing the mass analyser has fallen below a first predetermined threshold.

5. The method of claim 1 , further comprising, subsequently, if a further set of one or more conditions is met, automatically putting the mass spectrometer into an operating mode, in which voltage is supplied to one or more components of both the mass analyser and the ion optics between the source and the mass analyser.

6. The method of claim 5 , wherein the further set of one or more conditions includes a requirement that there is no fault detected within the mass analyser within a predetermined period after the voltage supply to the one or more components of the mass analyser is switched on based on automatically monitoring of the current associated with one or more components of the mass analyser, wherein the method comprises automatically monitoring the current associated with one or more components of the mass analyser for a predetermined period after the voltage supply to the one or more components of the mass analyser is switched on to ensure there is no fault within the mass analyser.

7. The method of claim 5 , wherein the mass spectrometer is automatically switched from the power save mode to the operating mode when the pressure within a vacuum chamber housing the mass analyser falls below a second predetermined threshold, wherein the second predetermined threshold is lower than the first predetermined threshold.

8. The method of claim 5 , wherein the further set of one or more conditions additionally includes a requirement that the voltage supplied to one or more components of the mass analyser has stabilised within a predetermined time period.

9. The method of claim 1 , wherein the mass spectrometer is configured such that it may be switched to a standby mode in which voltage is not supplied to any components of the mass analyser.

10. The method of claim 1 , wherein the mass spectrometer further comprises:
a vacuum chamber housing at least a portion of the ion optics of the spectrometer, and a backing pump operable to pump the vacuum chamber; and
a pump associated with one or more other vacuum chambers of the spectrometer downstream of the vacuum chamber housing the at least a portion of the ion optics for reducing the pressure within the one or more other vacuum chambers, wherein the pump is operable to pump a vacuum chamber housing the mass analyser of the spectrometer, and one or more further vacuum chamber housing a respective further portion of the ion optics;
the method comprising:
operating the backing pump to reduce the pressure in the vacuum chamber housing the at least a portion of the ion optics;
operating the backing pump to reduce the pressure in the vacuum chamber housing the at least a portion of the ion optics;
detecting when a backing pressure has decreased to a predetermined level, and then turning on the pump associated with the one or more other vacuum chambers of the spectrometer;
wherein the first set of one or more conditions includes a requirement that a pressure within the vacuum chamber housing the mass analyser has fallen below a first predetermined threshold; and
automatically switching the mass spectrometer from the power save mode to an operating mode when it is determined that a further set of one or more conditions is met, wherein the further set of one or more conditions includes a requirement that the pressure within the vacuum chamber housing the mass analyser has fallen below a second predetermined threshold, wherein the second predetermined threshold is lower than the first predetermined threshold, wherein, in the operating mode, voltage is supplied to one or more components of the mass analyser and to one or more components of the ion optics between the source and the mass analyser.

11. The method of claim 10 , wherein the mass spectrometer further comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use, and, when the pump associated with the one or more other vacuum chambers of the spectrometer reaches a predetermined speed, detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection.

12. The method of claim 11 , wherein the step of detecting the functional modules present is performed when a speed of the turbo pump relative to a maximum speed of the pump exceeds a predetermined threshold.

13. The method of claim 10 , wherein the pump associated with the one or more other vacuum chambers of the spectrometer is a turbo pump, wherein the method comprises turning on a pressure gauge of the mass analyser when a speed of the turbo pump relative to a maximum speed of the pump exceeds a predetermined threshold.

14. The method of claim 10 , further comprising automatically monitoring the current associated with one or more components of the mass analyser for a predetermined period after the voltage supply to the mass analyser is switched on to determine whether there is a fault within the mass analyser.

15. A mass spectrometer arranged to perform a start-up routine automatically upon switching ON the mass spectrometer, wherein the mass spectrometer comprises a mass analyser and ion optics for guiding ions from an ion source to the mass analyser in use,
wherein the start-up routine comprises, when a first set of one or more conditions is met, putting the mass spectrometer into a power save mode, wherein the power save mode is a mode in which voltage is supplied to one or more components of the mass analyser, and voltage is not supplied to one or more components of the ion optics between the source and the mass analyser.

16. The mass spectrometer of claim 15 further comprising:
a vacuum chamber housing at least a portion of the ion optics of the spectrometer, and a backing pump operable to pump the vacuum chamber; and
a pump associated with one or more other vacuum chambers of the spectrometer downstream of the vacuum chamber housing the at least a portion of the ion optics for reducing the pressure therein, wherein the pump is operable to pump a vacuum chamber housing the mass analyser of the spectrometer, and one or more further vacuum chamber hou

Assignees

• Micromass Ltd

Inventors

• Wamsley Ruth
• Johnson William
• Spreadbury Peter
• Doorbar Paul
• Wilson Michael

Classifications

• H01J49/40

  Time-of-flight spectrometers (H01J49/36 takes precedence) · CPC title

• H01J49/24

  Vacuum systems, e.g. maintaining desired pressures · CPC title

• H01J49/062

  Ion guides (linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421) · CPC title

• H01J49/022

  Circuit arrangements, e.g. for generating deviation currents or voltages (regulating electric or magnetic variables in general, e.g. current, magnetic field G05F); Components associated with high voltage supply (high voltage supply per se H02M) · CPC title

• H01J49/02

  Details · CPC title