Partially resorbable implants and methods

Patent metadata

Field	Value
Publication number	US-12263279-B2
Application number	US-202318174221-A
Country	US
Kind code	B2
Filing date	Feb 24, 2023
Priority date	May 18, 2015
Publication date	Apr 1, 2025
Grant date	Apr 1, 2025

Abstract

Implants including non-resorbable frameworks and resorbable components, as well as methods of use thereof are disclosed. The embodiments include different combinations of a non-resorbable framework (in some case structural and in other cases non-structural), and a resorbable component embedded within and/or around the framework (again, in some cases structural and in other cases non-structural). The disclosed implants provide an efficient means of providing structural support for the vertebral bodies post-implantation, as well as encouraging resorption of the implant and fusion of the associated vertebral bodies without negative side effects and/or failure, such as subsidence of the implant or cracking/fracturing of a portion of the implant when implanted.

First claim

The invention claimed is:

1. An implant sized and adapted for insertion into an intervertebral space between adjacent vertebral bodies comprising:
a non-resorbable, structural framework having top and bottom bone-contacting surfaces and a plurality of support columns extending between proximal and distal ends of the structural framework, the plurality of support columns being spaced apart from each other to define vertical openings in the framework, the structural framework including at least one keyed opening;
a resorbable material component within and/or around the framework for resorption and formation of new bone to fuse the vertebral bodies together, at least a portion of the structural framework being interposed between the resorbable material component, the resorbable material component having top and bottom bone-contacting surfaces arranged to contact vertebral endplates over a contact surface area sufficient to reduce peak stresses between the structural framework and the vertebral bodies to reduce or eliminate subsidence of the structural framework into the vertebral bodies, and
at least one bone anchor received in the at least one keyed opening to secure the bone anchor to the implant.

2. The implant of claim 1 , wherein the resorbable material component includes at least one resorbable keyed opening aligned with the at least one key opening of the structural framework.

3. The implant of claim 2 , wherein the at least one keyed opening extend from the proximal end to the distal end of the structural framework.

4. The implant of claim 2 , wherein structural framework includes four keyed openings and the resorbable component includes four corresponding resorbable keyed openings.

5. The implant of claim 1 , wherein the framework defines at least one opening extending through its top and bottom surfaces, and the resorbable material component is positioned within the at least one opening so as to encourage new bone formation through the at least one opening.

6. The implant of claim 1 , wherein the top and bottom bone-contacting surfaces of the resorbable material component are configured to support post-surgical loads experienced after implantation of the implant.

7. The implant of claim 1 , wherein the plurality of support columns extend longitudinally from the proximal end to the distal end of the structural framework.

8. The implant of claim 1 , wherein the structural framework includes an implantation tool opening to receive and engage with an implantation tool.

9. The implant of claim 1 , wherein the resorbable material component includes at least one vertical opening extending through a main body of the resorbable material component.

10. The implant of claim 1 , wherein the bone anchor includes a bladed portion and a keyed interconnection portion configured to be received in the at least one keyed opening of the structural framework.

11. The implant of claim 10 , wherein once engaged with the structural framework, the bladed portion of the bone anchor extends outwards from either the top or bottom surface of the structural framework.

12. The implant of claim 1 , wherein the resorbable material component is composed of a material selected from the group consisting of bioactive glass, bone, polylactides, collagen, magnesium alloy, or a Cross-Linked Microstructure (CLM) bioglass material.

13. An implant sized and adapted for insertion into an intervertebral space between adjacent vertebral bodies comprising:
a non-resorbable, structural framework having top and bottom bone-contacting surfaces and a plurality of support columns extending between proximal and distal ends of the structural framework, the plurality of support columns being spaced apart from each other to define vertical openings in the framework, the structural framework including at least one keyed opening;
a resorbable material component within and/or around the framework for resorption and formation of new bone to fuse the vertebral bodies together, the resorbable material component having top and bottom bone-contacting surfaces arranged to contact vertebral endplates over a contact surface area sufficient to reduce peak stresses between the structural framework and the vertebral bodies to reduce or eliminate subsidence of the structural framework into the vertebral bodies, the resorbable material component including at least one resorbable keyed opening aligned with the at least one key opening of the structural framework, and
at least one bone anchor received in the at least one keyed opening to secure the bone anchor to the implant.

14. The implant of claim 13 , wherein the resorbable material component includes at least one vertical opening extending through a main body of the resorbable material component.

15. The implant of claim 14 , further including bone-graft material disposed within the at least one vertical opening.

16. The implant of claim 14 , wherein the resorbable component reduces peak stresses between the structural framework and the vertebral bodies by about 40-80%.

17. The implant of claim 14 , wherein an overall contact surface area of the implant in contact with the vertebral endplates is between about 30-70%.

18. An implant sized and adapted for insertion into an intervertebral space between adjacent vertebral bodies comprising:
a non-resorbable, structural framework having top and bottom bone-contacting surfaces and including at least one keyed opening, and
a resorbable material component within and/or around the framework for resorption and formation of new bone to fuse the vertebral bodies together, the resorbable material component having top and bottom bone-contacting surfaces arranged to contact vertebral endplates over a contact surface area sufficient to reduce peak stresses between the structural framework and the vertebral bodies, the resorbable material component including a keyed interconnection portion that is substantially the same shape as the keyed opening of the structural framework,
wherein the keyed opening and the keyed interconnection portion are aligned to allow engagement of a bone anchor with the implant.

19. The implant of claim 18 , wherein the bone anchor includes a bladed portion and a keyed interconnection portion configured to be received in the at least one keyed opening of the structural framework.

20. The implant of claim 19 , wherein once engaged with the structural framework, the bladed portion of the bone anchor extends outwards from either the top or bottom surface of the structural framework.

Assignees

• Stryker European Operations Holdings Llc

Inventors

• Paddock Bradley William
• Sharifi-Mehr Amir Ali
• Wollowick Adam Laurance
• Buchert Oliver
• Havener Matthew B
• Cipoletti Robert
• Willis Steven
• Long Marc Gilles

Classifications

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61F2/4455

  for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages (intervertebral discs A61F2/442) · CPC title

• A61F2002/30387

  Dovetail connection · CPC title

• A61F2002/30032

  differing in absorbability or resorbability, i.e. in absorption or resorption time · CPC title

• A61F2002/30884

  Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity · CPC title