Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor

Patent metadata

Field	Value
Publication number	US-12263164-B2
Application number	US-202318451030-A
Country	US
Kind code	B2
Filing date	Aug 16, 2023
Priority date	Jan 21, 2014
Publication date	Apr 1, 2025
Grant date	Apr 1, 2025

Abstract

Therapeutic methods of treating chronic lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL) are described. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating subtypes of CLL and SLL using a BTK inhibitor, including subtypes of CLL in patients sensitive to thrombosis and subtypes of CLL that increase monocytes and NK cells in peripheral blood after treatment with a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a combination of a BTK inhibitor and an anti-CD20 antibody.

First claim

We claim:

1. A method of treating Waldenström's macroglobulinemia (WM) in a human subject suffering therefrom, comprising the step of orally administering to the human subject, a dose of 100 mg twice daily of a Bruton's tyrosine kinase (BTK) inhibitor, wherein the BTK inhibitor is a compound of Formula II:

or a pharmaceutically-acceptable salt, hydrate, or solvate thereof.

2. The method of claim 1 , wherein the BTK inhibitor is a compound of formula (II):

or a pharmaceutically acceptable salt thereof.

3. The method of claim 2 , wherein the BTK inhibitor is administered to the human subject for a period selected from the group consisting of about 14 days, about 28 days, and about 56 days.

4. The method of claim 2 , further comprising the step of administering a therapeutically effective dose of an anti-CD20 antibody selected from the group consisting of rituximab, obinutuzumab, ofatumumab, veltuzumab, tositumomab, ibritumomab, and fragments, derivatives, conjugates, variants, radioisotope-labeled complexes, and biosimilars thereof.

5. The method of claim 2 , wherein the free form of the compound of Formula (II) is administered to the human subject.

6. The method of claim 2 , wherein the pharmaceutically acceptable salt of the compound of Formula (II) is administered to the human subject.

7. The method of claim 4 , wherein the anti-CD20 antibody is obinutuzumab.

8. The method of claim 7 , wherein the obinutuzumab is administered intraveneously.

9. The method of claim 7 , wherein obinutuzumab is administered at a dose selected from the group consisting of about 100 mg, about 200 mg, about 300 mg, about 400 mg, about 500 mg, about 600 mg, about 700 mg, about 800 mg, about 900 mg, about 1000 mg, about 1100 mg, about 1200 mg, about 1300 mg, about 1400 mg, about 1500 mg, about 1600 mg, about 1700 mg, about 1800 mg, about 1900 mg, and about 2000 mg.

10. The method of claim 8 , wherein the obinutuzumab is administered at a dose of 100 mg.

11. The method of claim 8 , wherein the obinutuzumab is administered at a dose of 900 mg.

12. The method of claim 8 , wherein the obinutuzumab is administered at a dose of 1000 mg.

13. The method of claim 8 , wherein the BTK inhibitor is administered before obinutuzumab.

14. The method of claim 8 , wherein the BTK inhibitor is administered after obinutuzumab.

15. The method of claim 4 , wherein the anti-CD20 antibody is rituximab.

16. The method of claim 15 , wherein the rituximab is administered intravenously.

17. The method of claim 1 , wherein the BTK inhibitor is administered at an interval of about twelve hours.

18. The method of claim 1 , wherein the human subject has a 17p13.1 (17p) deletion.

Assignees

• Acerta Pharma Bv

Inventors

• Hamdy Ahmed
• Rothbaum Wayne
• Izumi Raquel
• Lannutti Brian
• Covey Todd
• Ulrich roger
• Johnson Dave
• Barf Tjeerd
• Kaptein Allard

Classifications

• C07K2317/732

  Antibody-dependent cellular cytotoxicity [ADCC] · CPC title

• C07K2317/24

  containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered · CPC title

• C07K16/2887

  against CD20 · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K39/39558

  against tumor tissues, cells, antigens · CPC title