Substituted 6-azabenzimidazole compounds

Patent metadata

Field	Value
Publication number	US-12258346-B2
Application number	US-202318543272-A
Country	US
Kind code	B2
Filing date	Dec 18, 2023
Priority date	Oct 31, 2018
Publication date	Mar 25, 2025
Grant date	Mar 25, 2025

Abstract

The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

First claim

What is claimed is:

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

3. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

4. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

5. A compound selected from the group consisting of:

and pharmaceutically acceptable salts thereof.

6. A compound of formu

Assignees

• Gilead Sciences Inc

Inventors

• Balan Gayatri
• Bartlett Mark J
• Chandrasekhar Jayaraman
• Codelli Julian A
• Conway John H
• Cosman Ellis Jennifer L
• Kalla Rao V
• Kasun Zachary A
• Kim Musong
• Lee Seung H
• Lo Jennifer R
• Loyer-Drew Jennifer A
• Mitchell Scott A
• Perry Thao D
• Phillips Gary B
• Salvo Patrick J
• Swaminathan Sundaramoorthi
• Van Veldhuizen Joshua J
• Yeung Suet C
• Zablocki Jeff

Classifications

• A61P31/20

  for DNA viruses · CPC title

• A61P31/18

  for HIV · CPC title

• C07D519/00

  Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 · CPC title

• C07D491/048

  the oxygen-containing ring being five-membered · CPC title

• C07D487/10

  Spiro-condensed systems · CPC title