Systems and methods for managing atrial-ventricular delay adjustments

Patent metadata

Field	Value
Publication number	US-12257440-B2
Application number	US-202318297784-A
Country	US
Kind code	B2
Filing date	Apr 10, 2023
Priority date	Aug 10, 2020
Publication date	Mar 25, 2025
Grant date	Mar 25, 2025

Abstract

A system and method are provided for managing atrial-ventricular (AV) delay adjustments. An AV interval is measured that corresponds to an interval between an atrial paced (Ap) event or an atrial sensed (As) event and a sensed ventricular (Vs) event. A candidate AV delay is set based on the AV interval and a bundle branch adjustment (BBA) value. A QRS characteristic of interest (COI) is measured while utilizing the candidate AV delay in connection with delivering a pacing therapy. The BBA value is adjusted and the candidate AV delay is reset based on the BBA value as adjusted. A collection of QRS COIs and corresponding candidate AV delays are obtained and one of the candidate AV delays is selected as a BBA AV delay. The pacing therapy is managed, based on the BBA AV delay.

First claim

What is claimed is:

1. A system comprising:
an implantable medical device (IMD) having a header that includes an atrial header port, and at least one ventricular (V) header port;
a first lead having a first electrode configured to be located proximate to an atrial (A) site, the first lead having a proximal end with a first lead terminal connected to the atrial header port; and
a second lead having a second electrode configured to be located proximate to at least one of a left bundle branch (LBB) site, a right bundle branch (RBB) site or a HIS bundle, the second lead having a proximal end with a second lead terminal connected to the at least one ventricular header port,
memory configured to store program instructions;
one or more processors that, when configured to execute the program instructions:
obtain a collection of QRS characteristics of interest (COI) and corresponding candidate AV delays, each of the candidate AV delays based on an AV interval and based on a corresponding bundle branch adjustment (BBA) value,
wherein the AV interval corresponding to an interval between i) an atrial paced (Ap) event or an atrial sensed (As) event, paced or sensed at the first electrode, and ii) a sensed ventricular (Vs) event sensed at the second electrode,
wherein each of the BBA values represents an adjustment to the AV interval to account for sensing the Vs event at the second electrode which is located proximate to at least one of the LBB site or the HIS bundle but connected to the V header port;

select one of the candidate AV delays, that corresponds to a select one of the QRS COIs, as a BBA AV delay; and
manage a pacing therapy, utilized by the IMD, based on the BBA AV delay.

2. The system of claim 1 , wherein the ventricular header port includes a right ventricular (RV) header port and wherein the one or more processors are configured, when executing the program instructions, to implement, as the pacing therapy, a DDD mode pacing therapy, wherein the second electrode represents an LBB electrode configured to be implanted through a septal wall to a depth sufficient to be located proximate to the LBB site, the second lead terminal configured to connect the LBB electrode to the RV header port; and
the IMD further comprising sensing circuitry configured to sense cardiac activity (CA) signals over an RV sensing channel, associated with the RV header port, wherein the CA signals are collected along a sensing vector defined at least in part by the LBB electrode.

3. The system of claim 1 , wherein the one or more processors are further configured to select the one of the candidate AV delays that manages delivery of pacing pulses at the LBB site at a select point in time before an intrinsic wave front is expected to propagate to or beyond a corresponding point along a right bundle branch.

4. The system of claim 1 , wherein the one or more processors are further configured to select the one of the candidate AV delays that resulted in a narrowest QRS duration within the collection of QRS COIs.

5. The system of claim 1 , wherein the one or more processors are further configured to repeatedly adjust the candidate AV delay by subtracting, from the AV interval, candidate BBA values in order to time delivery of pacing pulses at the LBB site at a point in time fused with intrinsic waveform propagation to or beyond a corresponding point along a right bundle branch.

6. The system of claim 1 , wherein the second electrode represents an LBB electrode configured to be implanted through a septal wall to a depth sufficient to be located proximate to the LBB site, the second lead terminal configured to connect the LBB electrode to the LV header port, wherein the pacing therapy corresponds to a cardiac resynchronization therapy (CRT) pacing therapy configured to deliver pacing pulses through the LV header port of the IMD to the LBB electrode.

7. The system of claim 1 , wherein the one or more processors are further configured to set, as the candidate AV delay, a candidate A-LV delay by adjusting the AV interval based on an AV offset and further subtracting a VV delay from the AV interval, the VV delay corresponding to the BBA value, the adjusting further comprising utilizing multiple candidate BBA values in order to time delivery of pacing pulses at the LBB site at a point in time fused with intrinsic waveform propagation to or beyond a corresponding point along a right bundle branch.

8. The system of claim 1 , wherein the system is configured to provide the pacing therapy when no electrodes are located proximate to an apex of the right ventricle.

9. The system of claim 1 , wherein the at least one V header port includes a left ventricular (LV) header port and a right ventricular (RV) header port, and wherein the system is configured to provide the pacing therapy when the LV and RV head ports are not connected to any electrode located proximate to an RV apex.

10. The system of claim 1 , wherein the BBA value provides an adjustment to the AV interval to account for the Vs event being sensed at the second electrode when configured to be located proximate to the LBB site and the second lead terminal is connected to a right ventricular header port.

11. The system of claim 1 , wherein the second electrode is configured to be located proximate to the HIS bundle and the second lead terminal is connected to a right ventricular header port, the system further comprising a third lead having a third electrode configured to be located proximate to a left ventricle and having a third lead terminal connected to a left ventricular header port.

12. The system of claim 1 , wherein the second electrode is configured to be located proximate to the HIS bundle and the second lead terminal is connected to a left ventricular header port, the system further comprising a third lead having a third electrode configured to be located proximate to a right ventricular (RV) apex and having a third lead terminal connected to a right ventricular header port.

13. A method comprising:
providing a first lead having a first electrode configured to be located proximate to an atrial (A) site, the first lead having a proximal end with a first lead terminal connected to an atrial header port of an implantable medical device (IMD); and
providing a second lead having a second electrode configured to be located proximate to at least one of a left bundle branch (LBB) site, a right bundle branch (RBB) site or a HIS bundle, the second lead having a proximal end with a second lead terminal connected to a ventricular (V) header port of the IMD;
utilizing one or more processors of the IMD for:
obtaining a collection of QRS characteristics of interest (COI) and corresponding candidate AV delays, each of the candidate AV delays based on the AV interval and based on a collection of bundle branch adjustment (BBA) values,
wherein the AV interval corresponding to an interval between i) an atrial paced (Ap) event or an atrial sensed (As) event, paced or sensed at the first electrode, and ii) a sensed ventricular (Vs) event sensed at the second electrode,
wherein each of the BBA values represents an adjustment to the AV interval to account for sensing the Vs event at the second electrode which is located proximate to at least one of a left bundle branch (LBB) site or a HIS bundle but connected to the V header port;

selecting one of the candidate AV delays, that corresponds to a select one of the QRS COIs, as a BBA AV delay; and
managing a pacing therapy, utilized by the IMD, based on the BBA AV delay.

14. The method of claim 13 , wherein the ventricular header port includes a right ventricular (RV) header port a

Assignees

• Pacesetter Inc

Inventors

• Li Wenwen
• Badie Nima
• Mcspadden Luke C
• Qiao Yun
• Fischer Avi
• Ryu Kyungmoo

Classifications

• A61N1/0587

  Epicardial electrode systems; Endocardial electrodes piercing the pericardium · CPC title

• A61N1/36843

  Bi-ventricular stimulation · CPC title

• A61N1/3682 Primary

  with a variable atrioventricular delay · CPC title