Crystalline salt forms
US-2021047368-A1 · Feb 18, 2021 · US
Crystalline salt forms
US12252553B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12252553-B2 |
| Application number | US-202218074151-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 2, 2022 |
| Priority date | Mar 11, 2016 |
| Publication date | Mar 18, 2025 |
| Grant date | Mar 18, 2025 |
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Abstract
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Disclosed are various crystalline salt forms of D-Arg-Dmt-Lys-Phe-NH 2 .
First claim
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What is claimed is: 1. A crystalline form of a tosylate salt of Compound I, wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 11.6, 12.2, 13.4, 15.4, 17.0, 20.2, 22.4, 22.7, and 23.1. 2. The crystalline form of claim 1 , wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 6.3, 11.6, 12.2, 13.4, 14.7, 15.4, 16.1, 17.0, 18.9, 20.2, 22.4, 22.7, and 23.1. 3. A crystalline form of a tosylate salt of Compound I, wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 6.5, 12.0, 13.0, 13.3, 15.7, 17.3, 19.4, 20.5, and 23.1. 4. The crystalline form of claim 3 , wherein said crystalline form has characteristic peaks in its XRPD pattern at values of two theta (° 2θ) of: 6.5, 11.6, 11.8, 12.0, 13.0, 13.3, 15.0, 15.7, 15.9, 17.3, 19.4, 19.6, 20.5, 22.4, 22.8, 23.1, and 23.7. 5. A composition, comprising a crystalline form of claim 1 . 6. A process for making a pharmaceutical composition comprising Compound I, comprising dissolving a crystalline form of claim 1 . 7. A composition, comprising a crystalline form of claim 3 . 8. A process for making a pharmaceutical composition comprising Compound I, comprising dissolving a crystalline form of claim 3 .
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Classifications
Crystalline forms, e.g. polymorphs · CPC title
Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Ophthalmic agents · CPC title
Optical isomers · CPC title
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- What does patent US12252553B2 cover?
- Disclosed are various crystalline salt forms of D-Arg-Dmt-Lys-Phe-NH 2 .
- Who is the assignee on this patent?
- Stealth Biotherapeutics Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K5/0817. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).