Deodorant compositions

Patent metadata

Field	Value
Publication number	US-12246081-B2
Application number	US-201816769518-A
Country	US
Kind code	B2
Filing date	Dec 12, 2018
Priority date	Dec 20, 2017
Publication date	Mar 11, 2025
Grant date	Mar 11, 2025

Abstract

The present invention relates to a deodorant composition comprising an oxazolidine- or, a thiazolidine-carboxylic acid compound, a cosmetic carrier and optionally a fragrance. The invention also relates to a manufacturing process for the deodorant composition, a method of treating malodour and a method of screening deodorant actives as well as inhibiting a Staphylococcus hominis C-S ≥-lyase.

First claim

The invention claimed is:

1. A human deodorant composition comprising:
(1) an oxazolidine-carboxylic acid compound; and
(2) a cosmetic carrier;
wherein the oxazolidine-carboxylic acid compound is:
(i) a compound of formula (I);
(ii) an ester of a compound of formula (I);
(iii) a salt of a compound of formula (I); or
(iv) a compound that releases a compound of formula (I) in use;

wherein X is O;
wherein R 1 , R 2 and R 3 are same or different group;
wherein R 1 is hydrogen, C3-C20 linear alkyl, C3-C20 branched alkyl, C3-C20 cyclic alkyl, C3-C20 alkenyl, C3-C20 aryl residue, or mixtures thereof;
wherein R 2 and R 3 are each independently C3-C20 linear alkyl, C3-C20 branched alkyl, C3-C20 cyclic alkyl, C3-C20 alkenyl, C3-C20 aryl residue, mixtures thereof, or linked to form a cyclic structure;
wherein the deodorant composition is a topical deodorant composition; and wherein the cosmetic carrier comprise a water-insoluble organic material.

2. The deodorant composition according to claim 1 , wherein R 1 is H.

3. The deodorant composition according to claim 1 , wherein the oxazolidine-carboxylic acid compound is selected from the group consisting of(S) (−)-3-(benzyloxycarbonyl)-4-oxazolidinecarboxylic acid, (R)-(+)-3-(benzyloxycarbonyl)-4-oxazolidinecarboxylic acid, (4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid, 1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid, 1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid wherein N is protected by carboxybenzyl (Cbz), 1,8-dioxa-4-azaspiro[4.5]decane-3-carboxylic acid, and 1,8-dioxa-4-azaspiro[4.5]decane-3-carboxylic acid wherein N is protected by Cbz.

4. The deodorant composition according to claim 1 , wherein the oxazolidine-carboxylic acid compound is present in an amount of 0.001% to 10% by weight based on a total weight of the deodorant composition.

5. The deodorant composition according to claim 1 , further comprising a delivery aid for the oxazolidine-carboxylic acid compound, wherein the delivery aid is an amino alcohol comprising at least 3 carbons.

6. The deodorant composition according to claim 1 , further comprising a fragrance.

7. A cosmetic method of treating malodour comprising topical application of a deodorant composition to a surface of human body, wherein the deodorant composition comprises:
(1) an oxazolidine-carboxylic acid compound; and
(2) a cosmetic carrier;
wherein the oxazolidine-carboxylic acid compound is:
(i) a compound of formula (I);
(ii) an ester of a compound of formula (I);
(iii) a salt of a compound of formula (I); or
(iv) a compound that releases a compound of formula (I) in use;

wherein X is O;
wherein R 1 , R 2 and R 3 are same or different group;
wherein R 1 is hydrogen, C3-C20 linear alkyl, C3-C20 branched alkyl, C3-C20 cyclic alkyl, alkenyl, aryl residue, or mixtures thereof;
wherein R 2 and R 3 are each independently C3-C20 linear alkyl, C3-C20 branched alkyl, C3-C20 cyclic alkyl, alkenyl, aryl residue, mixtures thereof, or linked to form a cyclic structure.

8. The cosmetic method according to claim 7 , wherein the oxazolidine-carboxylic acid compound inhibits C-S β layse.

9. The cosmetic method according to claim 7 , further comprising: dissolving or homogenously dispersing the oxazolidine-carboxylic acid compound in the cosmetic carrier.

Assignees

• Conopco Inc

Inventors

• Cox Diana Sheila
• James Alexander Gordon
• Puranik Mrinalini Jayant
• Thornthwaite David William
• Williams Jason Richard

Classifications

• A61Q15/00

  Anti-perspirants or body deodorants (deodorisation of air A61L9/00) · CPC title

• A61K2800/78

  Enzyme modulators, e.g. Enzyme agonists · CPC title

• A61K2800/59

  Mixtures · CPC title

• A61K8/66

  Enzymes · CPC title

• A61K8/49 Primary

  containing heterocyclic compounds · CPC title