Degradable polyethylene glycol conjugate

Patent metadata

Field	Value
Publication number	US-12239713-B2
Application number	US-201917042039-A
Country	US
Kind code	B2
Filing date	Mar 29, 2019
Priority date	Mar 29, 2018
Publication date	Mar 4, 2025
Grant date	Mar 4, 2025

Abstract

The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A):

wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

First claim

The invention claimed is:

1. A bio-related substance bonded to a degradable polyethylene glycol derivative, and represented by formula (A):

wherein D is the bio-related substance, and wherein

is ME-200GLFG(L)-200PA, ME-200GGG-200PA, ME-200GF-200PA, ME-200GAV-200PA, ME-200GFGG-200PA, or LY-(ME-100GLFG(L)-100) 2 -PA.

2. The bio-related substance according to claim 1 , wherein the bio-related substance for D is a hormone, a cytokine, an antibody, an aptamer or an enzyme.

3. The bio-related substance according to claim 1 , wherein

of the formula (A) is ME-200GLFG(L)-200PA.

4. The bio-related substance according to claim 3 , wherein the bio-related substance for D is a hormone, a cytokine, an antibody, an aptamer or an enzyme.

5. The bio-related substance according to claim 1 , wherein

of the formula (A) is ME-200GGG-200PA.

6. The bio-related substance according to claim 5 , wherein the bio-related substance for D is a hormone, a cytokine, an antibody, an aptamer or an enzyme.

7. The bio-related substance according to claim 1 , wherein

of the formula (A) is ME-200GF-200PA.

8. The bio-related substance according to claim 7 , wherein the bio-related substance for D is a hormone, a cytokine, an antibody, an aptamer or an enzyme.

9. The bio-related substance according to claim 1 , wherein

of the formula (A) is ME-200GAV-200PA.

10. The bio-related substance according to claim 9 , wherein the bio-related substance for D is a hormone, a cytokine, an antibody, an aptamer or an enzyme.

11. The bio-related substance according to claim 1 , wherein

of the formula (A) is ME-200GFGG-200PA.

12. The bio-related substance according to claim 11 , wherein the bio-related substance for D is a hormone, a cytokine, an antibody, an aptamer or an enzyme.

13. The bio-related substance according to claim 1 , wherein

of the formula (A) is LY-(ME-100GLFG(L)-100) 2 -PA.

14. The bio-related substance according to claim 13 , wherein the bio-related substance for D is a hormone, a cytokine, an antibody, an aptamer or an enzyme.

Assignees

• Nof Corp
• Tokyo Inst Tech

Inventors

• Yoshioka Hiroki
• Kamiya Masaki
• Yamamoto Yuji
• Hirai Midori
• Sasaki Akiko
• Nishiyama Nobuhiro
• Matsui Makoto
• Takemoto Hiroyasu
• Miyauchi Kazuki
• Nomoto Takahiro
• Tomoda Keishiro

Classifications

• C08G65/33396

  having oxygen in addition to nitrogen · CPC title

• C07K19/00

  Hybrid peptides {, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes} · CPC title

• C07K7/06

  having 5 to 11 amino acids · CPC title

• C07K5/1008

  the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala · CPC title

• A61K38/27

  Growth hormone [GH], i.e. somatotropin · CPC title