Inhibitors of autophagy and DCAR-1 as novel anthelmintic agents

Patent metadata

Field	Value
Publication number	US-12233036-B2
Application number	US-201916724467-A
Country	US
Kind code	B2
Filing date	Dec 23, 2019
Priority date	Feb 21, 2019
Publication date	Feb 25, 2025
Grant date	Feb 25, 2025

Abstract

Methods and compositions for controlling parasitic nematodes and treating or preventing a parasitic nematode infection are described herein. The methods include the use of compositions containing an autophagy inhibitor and/or a DCAR-1 inhibitor as anthelmintic agents.

First claim

What is claimed is:

1. An anthelmintic composition comprising an active agent and an excipient,
wherein the active agent consists of an autophagy inhibitor and a DCAR-1 inhibitor,
wherein the DCAR-1 inhibitor is dihydrocaffeic acid.

2. The anthelmintic composition of claim 1 , wherein the autophagy inhibitor is present in an amount of 1 to 1000 μg/ml and the DCAR-1 inhibitor is present in an amount of 1 to 1000 μg/ml.

3. The anthelmintic composition of claim 1 , wherein the excipient is a pharmaceutically acceptable excipient.

4. The anthelmintic composition of claim 1 , wherein the excipient is an agriculturally acceptable excipient.

5. An anthelmintic composition comprising an active agent and an excipient, wherein the active agent consists of dihydrocaffeic acid and an anthelmintic agent selected from the group consisting of autophinib, azithromycin, ARN5187, AS1842856, autophagy inhibitor VII, bafilomycin Al, (±)-Bay K8644, 3BDO, chloroquine, concanamycin A, CA-5f, daurisoline, DBeQ, E64d, DC661, EAD1, edaravone, 5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, GMX1778, GW4064, hydroxychloroquine sulfate, IITZ-01, KU-55933, L-asparagine, leupeptin, liensinine, lucanthone, LY294002 hydrochloride, Lys0I trihydrochloride, Lys05, Mdivi-1, 3-methyladenine, MHY1485, ML240, MRT67307 dihydrochloride, MRT68601 hydrochloride, MRT68921 dihydrochloride, NMS873, nocodazole, paclitaxel, PD98059, pepstatin A, PFK15, PFK158, PHY34, PIK-III, rapamycin, ROC-325, SAR-405, SB202190, SB203580, SBI-0206965, SP600125, sinomenine, spautin 1, thapsigargin, ULK-101, U0126, vinblastine sulfate, wortmannin, and xanthohumol.

6. The anthelmintic composition of claim 5 , wherein the dihydrocaffeic acid is present in an amount of 1 to 1000 μg/ml.

7. The anthelmintic composition of claim 5 , wherein the excipient is a pharmaceutically acceptable excipient.

8. The anthelmintic composition of claim 5 , wherein the excipient is an agriculturally acceptable excipient.

Assignees

• Florida Atlantic Univ Board Of Trustees

Inventors

• Jia Kailiang
• Parker Thomas

Classifications

• A61K31/192 Primary

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61P33/10

  Anthelmintics · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A01N37/38

  having at least one oxygen or sulfur atom attached to an aromatic ring system · CPC title