Process for bio-1,3-butanediol purification from a fermentation broth

Patent metadata

Field	Value
Publication number	US-12227467-B2
Application number	US-201917277968-A
Country	US
Kind code	B2
Filing date	Sep 19, 2019
Priority date	Sep 21, 2018
Publication date	Feb 18, 2025
Grant date	Feb 18, 2025

Abstract

A process for bio-1,3-butanediol purification from a fermentation broth includes the steps of: (a) subjecting the fermentation broth to separation, (b) subjecting the product obtained in step (a) to treatment with ion-exchange resins, (c) subjecting the product obtained in step (b) to a first evaporation, (d) subjecting the product obtained in step (c) to a second evaporation; and (e) subjecting the product obtained in step (d) to a third evaporation, obtaining purified bio-1,3-butanediol. The purified bio-1,3-butanediol can be used to produce bio-1,3-butadiene. Bio-1,3-butadiene can be used as a monomer or as an intermediate to produce elastomers and (co)polymers.

First claim

The invention claimed is:

1. A process for bio-1,3-butanediol purification from a fermentation broth, the process comprising the following steps:
(a) subjecting the fermentation broth to separation;
(b) subjecting the product obtained in step (a) to treatment with ion-exchange resins;
(c) subjecting the product obtained in step (b) to a first evaporation at a temperature ranging from 30° C. to 100° C. and/or at a pressure ranging from 5 mbar to 100 mbar;
(d) subjecting the product obtained in step (c) to a second evaporation; and
(e) subjecting the product obtained in step (d) to a third evaporation, thereby obtaining purified bio-1,3-butanediol.

2. The process according to claim 1 , wherein step (a) comprises the following steps:
(a 1a ) microfiltration; and
(a 2 ) nanofiltration.

3. The process according to claim 1 , wherein step (a) comprises the following steps:
(a 1b ) centrifugation; and
(a 2 ) nanofiltration.

4. The process according to claim 2 , wherein step (a 1a ) is carried out:
by membranes having a mean pore diameter ranging from 0.01 μm to 1.0 μm; and/or
operating at a transmembrane pressure ranging from 0.1 bar to 8 bar, the transmembrane pressure being defined as an average pressure between a pressure measured upstream and a pressure measured downstream of a microfiltration module; and/or
at a temperature ranging from 20° C. to 90° C.; and/or
by ceramic membranes that are submerged or in a cross flow configuration or in a dynamic cross flow configuration, or by flat or hollow-fibre polymer membranes that are submerged or in a cross flow configuration.

5. The process according to claim 3 , wherein step (a 1b ) is carried out:
at a temperature ranging from 20° C. to 90° C.; and/or
operating at a centrifugal feed rate ranging from 50 l/h to 1000 l/h; and/or
at a rotation speed ranging from 2000 rpm to 50000 rpm.

6. The process according to claim 2 , wherein step (a 2 ) is carried out:
by nanofiltration membranes having a molecular weight cut-off (MWCO) ranging from 100 daltons to 500 daltons; and/or
by nanofiltration membranes having a maximum operating temperature ranging from 15° C. to 100° C.; and/or
operating at a transmembrane pressure ranging from 10 bar to 50 bar, the transmembrane pressure being defined as an average pressure between a pressure measured upstream and a pressure measured downstream of a nanofiltration module.

7. The process according to claim 1 , wherein step (b) comprises the steps:
(b 1 ) an anion exchange step; and
(b 2 ) a cation exchange step.

8. The process according to claim 7 , wherein step (b 1 ) is carried out with a column containing a weak anionic resin.

9. The process according to claim 7 , wherein step (b 2 ) is carried out with a column containing a strong cationic resin.

10. The process according to claim 7 , wherein steps (b 1 ) and (b 2 ) are carried out at a flow rate in litres of product obtained in step (a) per hour ranging from 2 BV/h to 4 BV/h, wherein BV is Bed Volume which is volume of resin per single column.

11. The process according to claim 7 , wherein the product obtained from steps (b 1 ) and (b 2 ) has a residual conductivity ranging from 0.1 μS/cm to 100 μS/cm.

12. The process according to claim 7 , wherein the product obtained in step (a) is fed to step (b 1 ) and subsequently to step (b 2 ), or is fed to step (b 2 ) and subsequently to step (b 1 ).

13. The process according to claim 1 , wherein step (d) is carried out:
at a temperature ranging from 30° C. to 150° C.; and/or
at a pressure ranging from 1 mbar to 100 mbar.

14. The process according to claim 1 , wherein (e) is carried out:
at a temperature ranging from 30° C. to 150° C.; and/or
at a pressure ranging from 5 mbar to 100 mbar.

15. A process for bio-1,3-butanediol purification from a fermentation broth, the process comprising the following steps:
(a) subjecting the fermentation broth to separation;
(b) subjecting the product obtained in step (a) to treatment with ion-exchange resins;
(c) subjecting the product obtained in step (b) to a first evaporation;
(d) subjecting the product obtained in step (c) to a second evaporation; and
(e) subjecting the product obtained in step (d) to a third evaporation, thereby obtaining purified bio-1,3-butanediol,
wherein step (b) includes an anion exchange step (b 1 ) and a cation exchange step (b 2 ), wherein steps (b 1 ) and (b 2 ) are carried out at a flow rate in litres of product obtained in step (a) per hour ranging from 2 BV/h to 4 BV/h, and wherein BV is Bed Volume, which is volume of resin per single column.

16. A process for bio-1,3-butanediol purification from a fermentation broth, the process comprising the following steps:
(a) subjecting the fermentation broth to separation;
(b) subjecting the product obtained in step (a) to treatment with ion-exchange resins;
(c) subjecting the product obtained in step (b) to a first evaporation;
(d) subjecting the product obtained in step (c) to a second evaporation at a temperature ranging from 30° C. to 150° C. and/or at a pressure ranging from 1 mbar to 100 mbar; and
(e) subjecting the product obtained in step (d) to a third evaporation, thereby obtaining purified bio-1,3-butanediol.

17. A process for bio-1,3-butanediol purification from a fermentation broth, the process comprising the following steps:
(a) subjecting the fermentation broth to separation;
(b) subjecting the product obtained in step (a) to treatment with ion-exchange resins;
(c) subjecting the product obtained in step (b) to a first evaporation;
(d) subjecting the product obtained in step (c) to a second evaporation; and
(e) subjecting the product obtained in step (d) to a third evaporation at a temperature ranging from 30° C. to 150° C. and/or at a pressure ranging from 5 mbar to 100 mbar, thereby obtaining purified bio-1,3-butanediol.

Assignees

• Versalis Spa

Inventors

• Baldassarre Mario
• Cesana Alberto
• Bordes Fabrizio

Classifications

• B01D2325/02834

  more than 0.1 and up to 1 µm · CPC title

• C12P7/18

  polyhydric · CPC title

• C08F36/06

  Butadiene · CPC title

• C07C29/80

  by distillation · CPC title

• C07C1/24

  by elimination of water · CPC title