pH-modulating biodegradable polymer and poly(glycerol sebacate)-augmented cell culture media

Patent metadata

Field	Value
Publication number	US-12221618-B2
Application number	US-202117405168-A
Country	US
Kind code	B2
Filing date	Aug 18, 2021
Priority date	Jan 17, 2018
Publication date	Feb 11, 2025
Grant date	Feb 11, 2025

Abstract

A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).

First claim

What is claimed is:

1. A pH-modulating poly(glycerol sebacate) composition comprising poly(glycerol sebacate) and at least one pH-modulating agent covalently attached to the poly(glycerol sebacate), wherein the at least one pH-modulating agent is present in the pH-modulating poly(glycerol sebacate) composition in an amount, by weight, of about 5% or greater with respect to the weight of the pH-modulating poly(glycerol sebacate) composition.

2. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the at least one pH-modulating agent is selected from the group consisting of an inorganic salt, an amino acid, and a protein.

3. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the at least one pH-modulating agent is selected from the group consisting of arginine, histidine, and tyrosine.

4. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the at least one pH-modulating agent is lysine.

5. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the at least one pH-modulating agent crosslinks the poly(glycerol sebacate).

6. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the at least one pH-modulating agent reduces a decrease in pH of a buffered aqueous solution containing the pH-modulating poly(glycerol sebacate) composition caused by degradation of the poly(glycerol sebacate).

7. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a resin and a thermoset.

8. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the pH-modulating poly(glycerol sebacate) composition is a coating.

9. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a microparticle, a scaffold, and a fiber.

10. The pH-modulating poly(glycerol sebacate) composition of claim 1 , wherein the at least one pH-modulating agent is present in the pH-modulating poly(glycerol sebacate) composition in an amount, by weight, of about 10% or greater with respect to the weight of the pH-modulating poly(glycerol sebacate) composition.

11. A pH-modulating poly(glycerol sebacate) composition comprising poly(glycerol sebacate) and at least one pH-modulating agent covalently attached to the poly(glycerol sebacate), wherein the at least one pH-modulating agent crosslinks the poly(glycerol sebacate).

12. The pH-modulating poly(glycerol sebacate) composition of claim 11 , wherein the at least one pH-modulating agent is selected from the group consisting of an inorganic salt, an amino acid, and a protein.

13. The pH-modulating poly(glycerol sebacate) composition of claim 11 , wherein the at least one pH-modulating agent is selected from the group consisting of arginine, histidine, and tyrosine.

14. The pH-modulating poly(glycerol sebacate) composition of claim 11 , wherein the at least one pH-modulating agent is lysine.

15. The pH-modulating poly(glycerol sebacate) composition of claim 11 , wherein the at least one pH-modulating agent reduces a decrease in pH of a buffered aqueous solution containing the pH-modulating poly(glycerol sebacate) composition caused by degradation of the poly(glycerol sebacate).

16. The pH-modulating poly(glycerol sebacate) composition of claim 11 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a resin and a thermoset.

17. The pH-modulating poly(glycerol sebacate) composition of claim 11 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a coating, a microparticle, a scaffold, and a fiber.

18. A pH-modulating poly(glycerol sebacate) composition comprising poly(glycerol sebacate) and at least one pH-modulating agent covalently attached to the poly(glycerol sebacate), wherein the at least one pH-modulating agent is selected from the group consisting of arginine, histidine, and tyrosine.

19. The pH-modulating poly(glycerol sebacate) composition of claim 18 , wherein the at least one pH-modulating agent reduces a decrease in pH of a buffered aqueous solution containing the pH-modulating poly(glycerol sebacate) composition caused by degradation of the poly(glycerol sebacate).

20. The pH-modulating poly(glycerol sebacate) composition of claim 18 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a resin and a thermoset.

21. The pH-modulating poly(glycerol sebacate) composition of claim 18 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a coating, a microparticle, a scaffold, and a fiber.

22. A pH-modulating poly(glycerol sebacate) composition comprising poly(glycerol sebacate) and at least one pH-modulating agent covalently attached to the poly(glycerol sebacate), wherein the at least one pH-modulating agent is lysine.

23. The pH-modulating poly(glycerol sebacate) composition of claim 22 , wherein the at least one pH-modulating agent reduces a decrease in pH of a buffered aqueous solution containing the pH-modulating poly(glycerol sebacate) composition caused by degradation of the poly(glycerol sebacate).

24. The pH-modulating poly(glycerol sebacate) composition of claim 22 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a resin and a thermoset.

25. The pH-modulating poly(glycerol sebacate) composition of claim 22 , wherein the pH-modulating poly(glycerol sebacate) composition is of a form selected from the group consisting of a coating, a microparticle, a scaffold, and a fiber.

Assignees

• Secant Group Llc

Inventors

• Gabriele Peter D
• Harris Jeremy J
• Nicholson Charles Brendan
• Lu Steven
• Ginn Brian

Classifications

• A61L27/38

  containing added animal cells (organs or tissue containing native cells A61L27/36) · CPC title

• C08L67/00

  Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain (of polyester-amides C08L77/12; of polyester-imides C08L79/08); Compositions of derivatives of such polymers · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title

• C08K3/26

  Carbonates; Bicarbonates · CPC title

• C08K3/32

  Phosphorus-containing compounds · CPC title