Measuring apparatus

Patent metadata

Field	Value
Publication number	US-12216048-B2
Application number	US-202118014756-A
Country	US
Kind code	B2
Filing date	Jul 8, 2021
Priority date	Jul 30, 2020
Publication date	Feb 4, 2025
Grant date	Feb 4, 2025

Abstract

A measuring apparatus includes a light source configured to emit light in a mid-infrared region, the light including: first-wavelength light having a wave number of from 970 cm −1 or more to 1010 cm −1 or less; and second-wavelength light different from the first-wavelength light, the second-wavelength light having a wave number of from 950 cm −1 or more to 990 cm −1 or less; a photosensor configured to detect the light emitted from the light source and reflected by a measurement target; and an information processing device configured to: obtain a first absorbance of the first-wavelength light and a second absorbance of the second-wavelength light from an output of the photosensor; and determine a biomarker of the measurement target based on the first absorbance and the second absorbance.

First claim

The invention claimed is:

1. A measuring apparatus, comprising:
a light source to emit light in a mid-infrared region, the light including:
first-wavelength light having a wave number of from 970 cm-1 or more to 1010 cm-1 or less; and
second-wavelength light different from the first-wavelength light, the second-wavelength light having a wave number of from 950 cm-1 or more to 990 cm-1 or less;
a photosensor to detect the light emitted from the light source and reflected by a measurement target; and
information processing circuitry configured to:
obtain a first absorbance of the first-wavelength light and a second absorbance of the second-wavelength light from an output of the photosensor; and
determine a biomarker of the measurement target based on the first absorbance and the second absorbance.

2. A measuring apparatus comprising:
a light source to emit light in a mid-infrared region, the light including first-wavelength light and second-wavelength light different from the first-wavelength light, each having a wave number of from 1130 cm-1 or more to 1220 cm-1 or less;
a photosensor to detect the light emitted from the light source and reflected by a measurement target; and
an information processing circuitry configured to:
obtain a first absorbance of the first-wavelength light and a second absorbance of the second-wavelength light from an output of the photosensor; and
determine a biomarker of the measurement target based on the obtained first absorbance and the second absorbance.

3. The measuring apparatus according to claim 2 ,
wherein the first—wavelength light has a wave number ranging from 1156 cm-1 or more to 1164 cm-1 or less, and the second—wavelength light has a wave number ranging from 1164 cm-1 or more to 1174 cm-1 or less.

4. The measuring apparatus according to claim 2 ,
wherein the first—wavelength light has a wave number ranging from 1134 cm-1 or more to 1146 cm-1 or less, and the second—wavelength light has a wave number ranging from 1170 cm-1 or more to 1216 cm-1 or less.

5. The measuring apparatus according to claim 1 ,
wherein the information processing circuitry is configured to:
divide the first absorbance by the second absorbance to obtain a value; and
estimate the biomarker based on the value.

6. The measuring apparatus according to claim 1 ,
wherein the light further includes third—wavelength light having a wave number of from 1700 cm-1 or more to 1760 cm-1 or less, and
wherein the information processing circuitry is configured to determine the biomarker based on the first absorbance, the second absorbance, and a third absorbance of the third—wavelength light.

7. The measuring apparatus according to claim 1 ,
wherein the light further includes third—wavelength light having a wave number of from 1130 cm-1 or more to 1220 cm-1 or less, and
wherein the information processing circuitry is configured to determine the biomarker based on the first absorbance, the second absorbance, and a third absorbance of the third—wavelength light.

8. The measuring apparatus according to claim 2 ,
wherein the light further includes third—wavelength light having a wave number of from 970 cm-1 or more to 1010 cm-1 or less or from 950 cm-1 or more to 990 cm-1 or less, and
wherein the information processing circuitry is configured to determine the biomarker based on the first absorbance, the second absorbance, and a third absorbance of the third—wavelength light.

9. The measuring apparatus according to claim 6 ,
wherein the information processing circuitry is configured to:
determine a normalized line to have a ratio of the second absorbance to the third absorbance being 1; and
normalize the first absorbance using the normalized line.

10. The measuring apparatus according to claim 1 ,
wherein the information processing circuitry is further configured to:
obtain a cross—correlation value from a preliminarily—acquired absorption spectrum of a substance to be measured within the measurement target and an absorption spectrum of the measurement target acquired from the output of the photosensor; and
estimate the biomarker of the measurement target based on the cross—correlation value.

11. The measuring apparatus according to claim 1 , further comprising—
a measurement optical structure between the light source and the photosensor, the measurement optical structure to emit light reflected by the measurement target, to the photosensor.

12. The measuring apparatus according to claim 11 ,
wherein the measurement optical structure element is an attenuated total reflection prism.

13. The measuring apparatus according to claim 2 ,
wherein the information processing circuitry is configured to:
divide the first absorbance by the second absorbance to obtain a value; and
estimate the biomarker based on the value.

14. The measuring apparatus according to claim 2 ,
wherein the light further includes third—wavelength light having a wave number of from 1700 cm-1 or more to 1760 cm-1 or less, and
wherein the information processing circuitry is configured to determine the biomarker based on the first absorbance, the second absorbance, and a third absorbance of the third—wavelength light.

15. The measuring apparatus according to claim 14 ,
wherein the information processing circuitry is configured to:
determine a normalized line to have a ratio of the second absorbance to the third absorbance being 1; and
normalize the first absorbance using the normalized line.

16. The measuring apparatus according to claim 2 ,
wherein the information processing circuitry is further configured to:
obtain a cross—correlation value from a preliminarily—acquired absorption spectrum of a substance to be measured within the measurement target and an absorption spectrum of the measurement target acquired from the output of the photosensor; and
estimate the biomarker of the measurement target based on the cross—correlation value.

17. The measuring apparatus according to claim 2 , further comprising:
a measurement optical structure between the light source and the photosensor, the measurement optical structure to emit light reflected by the measurement target, to the photosensor.

18. The measuring apparatus according to claim 17 ,
wherein the measurement optical structure is an attenuated total reflection prism.

Assignees

• Kasahara Ryosuke
• Wada Yoshio
• Oba Yoshihiro
• Sasaki Toshihide
• Ricoh Co Ltd

Inventors

• Kasahara Ryosuke
• Wada Yoshio
• Oba Yoshihiro
• Sasaki Toshihide

Classifications

• G01N2201/0634

  Diffuse illumination · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/14551

  for measuring blood gases · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• G01N21/3563

  for analysing solids; Preparation of samples therefor · CPC title