Fluid injector system, method of preventing fluid backflow, and computer program product

Patent metadata

Field	Value
Publication number	US-12208239-B2
Application number	US-201917270531-A
Country	US
Kind code	B2
Filing date	Aug 27, 2019
Priority date	Aug 28, 2018
Publication date	Jan 28, 2025
Grant date	Jan 28, 2025

Abstract

A fluid injector system and method for preventing pressurized backflow of a second fluid into a first reservoir containing a fluid is described. The fluid injector system includes a control device programmed or configured to actuate a second drive component to pressurize and inject the second fluid through the fluid conduit, and while the second drive component is actuated, actuate a first drive component to introduce intermittent pulses of the first fluid to create a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir.

First claim

We claim:

1. A fluid injector system configured to perform an injection protocol, the fluid injector system comprising:
a control device operatively associated with each of two or more drive components configured to pressurize and inject a first fluid from a first fluid reservoir through a fluid conduit, and at least a second fluid from a second fluid reservoir through the fluid conduit, the fluid conduit being in selective fluid communication with the first fluid reservoir and at least the second fluid reservoir, the control device comprising at least one processor programmed or configured to:
actuate a second drive component of the two or more drive components to pressurize and inject the second fluid through the fluid conduit;
while the second drive component of the two or more drive components is actuated, actuate a first drive component of the two or more drive components to introduce a first set of intermittent pulses of the first fluid to create a turbulent flow in the fluid path at a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir,
monitor a pressure in the first fluid reservoir and a pressure in the second fluid reservoir during injection of the first fluid and the second fluid to determine if a difference between the pressure in the first fluid reservoir and the pressure in the second fluid reservoir reaches a first predetermined value, and
once the first predetermined value is reached, start a second set of intermittent pulses of the first fluid through the fluid conduit in order to prevent the second fluid from entering the first fluid reservoir.

2. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to actuate the first drive component of the two or more drive components to continue to introduce the first set of intermittent pulses of the first fluid until a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid.

3. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to further actuate the first drive component of the two or more drive components to introduce the first set of intermittent pulses of the first fluid at a frequency or amplitude selected from the group consisting of an increasing frequency, a decreasing frequency, an increasing amplitude, a decreasing amplitude, and any combination thereof, based on at least one of a difference in pressure in the first fluid reservoir compared to the second fluid reservoir, a difference in an observed ratio of the first fluid and the second fluid compared to a desired ratio of the first fluid and the second fluid, a change in a fluid flow rate or pressure in the fluid conduit, a detection of backflow of the second fluid, a difference in fluid properties of the first fluid and the second fluid, and combinations of any thereof.

4. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to decrease at least one of a frequency and an amplitude of or alter a wave form of the first set of intermittent pulses of the first fluid and deliver the first fluid at a first fluid flow rate and the second fluid at a second fluid flow rate at a desired ratio of the first fluid and the second fluid through the fluid conduit.

5. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to monitor an injection pressure in the fluid conduit and determine whether the injection pressure changes by a second predetermined value.

6. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to calculate a predetermined injection pressure based on at least one of a programmed injection protocol and user input information, and in response, adjust a pre-set waveform of the first set of intermittent pulses of the first fluid.

7. The fluid injector system of claim 1 , wherein the at least one processor is further programmed or configured to continuously monitor a rate of change of an injection pressure in the fluid conduit, and in response, adjust at least one of a pulse interval, a pulse flow rate, and a pulse volume of the first set of intermittent pulses of the first fluid based on a lookup table or a predetermined algorithm.

8. The fluid injector system of claim 1 , wherein, when the first set of intermittent pulses of the first fluid are introduced, the at least one processor is further programmed or configured to select at least one of a pulse interval, a pulse flow rate, and a pulse volume from a lookup table or a predetermined algorithm.

9. The fluid injector system of claim 1 , wherein less than 40 milliliters of the first fluid is introduced into the fluid conduit by actuation of the first drive component of the two or more drive components before a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid.

10. The fluid injector system of claim 1 , wherein, while the first drive component of the two or more drive components introduces the first set of intermittent pulses of the first fluid to create the flow front interface between the first fluid and the second fluid in the fluid conduit, a total volume of the first fluid introduced into the fluid conduit is less than the sum of a user programmed volume and 15 milliliters.

11. The fluid injector system of claim 1 , wherein, when the first drive component of the two or more drive components is actuated, a capacitance volume of the first fluid reservoir increases and none of the second fluid enters the first fluid reservoir.

12. A fluid injector system configured to perform an injection protocol, the fluid injector system comprising:
a control device operatively associated with each of two or more drive components configured to pressurize and inject a first fluid from a first fluid reservoir through a fluid conduit, and at least a second fluid from a second fluid reservoir through the fluid conduit, the fluid conduit being in selective fluid communication with the first fluid reservoir and at least the second fluid reservoir, the control device comprising at least one processor programmed or configured to:
actuate a second drive component of the two or more drive components to pressurize and inject the second fluid through the fluid conduit;
while the second drive component is actuated, actuate a first drive component of the two or more drive components to introduce a first set of intermittent pulses of the first fluid to create a turbulent flow in the fluid path at a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit in to the first fluid reservoir;
continue to introduce the first set of intermittent pulses of the first fluid until a pressure of the first fluid reaches a pressure that is substantially the same as a pressure of the second fluid;
decrease at least one of a frequency and an amplitude of or alter a wave form of the first set of intermittent pulses of the first fluid and deliver the first fluid at a first fluid flow rate and the second fluid at a second fluid flow rate at a desired ratio of the first fluid and the second fluid through the fluid conduit;
either monitor a pressure in the first fluid reservoir and a pressure in the second fluid reservoir during injection of the first fluid and the second fluid to determine if a difference between the pressure in the first fluid r

Assignees

• Bayer Healthcare Llc

Inventors

• Mcdermott Michael
• Barone William
• Volkar John

Classifications

• A61M2005/14208

  with a programmable infusion control system, characterised by the infusion program · CPC title

• A61M2005/1406

  Minimizing backflow along the delivery catheter track · CPC title

• A61M5/16854

  by monitoring line pressure · CPC title

• A61M5/1422

  with double acting or multiple pistons · CPC title

• A61M5/007 Primary

  for contrast media · CPC title