Deactivation of circulating tumor cells (CTCs) in the bloodstream by electrostatic stimulation of the peripheral blood

Patent metadata

Field	Value
Publication number	US-12208189-B2
Application number	US-202117207656-A
Country	US
Kind code	B2
Filing date	Mar 20, 2021
Priority date	Jul 4, 2017
Publication date	Jan 28, 2025
Grant date	Jan 28, 2025

Abstract

A method for deactivating circulating cancer cells (CTCs). The method includes reducing viability of CTCs and/or destroying CTCs by applying a positive electrostatic field to bloodstream of a cancer patient.

First claim

What is claimed is:

1. A system for deactivating circulating cancer cells (CTCs), comprising:
a tubing line comprising a fluidic channel, the fluidic channel comprising a portion of the tubing line having a spiral u-shape with two ends, the two ends comprising an inlet and an outlet;
at least two peristaltic pumps, configured to circulate a flow of bloodstream through the tubing line, the at least two peristaltic pumps comprising:
a first peristaltic pump configured to:
extract bloodstream of a cancer patient' body into the inlet of the fluidic channel; and
pass the extracted bloodstream through the fluidic channel; and

a second peristaltic pump configured to transmit the bloodstream from the outlet of the fluidic channel into the cancer patient's body:

an electrically conductive element placed on the fluidic channel, the electrically conductive element configured to accumulate positive electrostatic charges thereon;
an electrostatic charge generator electrically connected to the electrically conductive element, the electrostatic charge generator configured to apply a positive electrostatic voltage to the electrically conductive element; and
a processing unit electrically connected to the electrostatic charge generator and the at least two peristaltic pumps, the processing unit comprising:
a memory having processor-readable instructions stored therein; and
a processor configured to access the memory and execute the processor-readable instructions, which, when executed by the processor configures the processor to perform a method, the method comprising:
circulating a portion of the bloodstream of the cancer patient's body inside the fluidic channel utilizing the at least two peristaltic pumps:
accumulating positive electrostatic charges on the electrically conductive element by applying the positive electrostatic voltage to the electrically conductive element utilizing the electrostatic charge generator; and
forming deactivated CTCs in the circulating portion of the bloodstream by at least one of reducing viability of CTCs and destroying CTCs responsive to electrostatically stimulating of CTCs induced by the accumulated positive electrostatic charges.

2. The system of claim 1 , wherein the electrically conductive element comprises at least one of an electrical conductive plate and an electrical conductive tape.

3. The system of claim 1 , wherein the electrically conductive element comprises:
at least one of an electrical insulator plate and an electrical insulator tape; and
a layer of an electrical conductive material covered on the least one of an electrical insulator plate and an electrical insulator tape.

4. The system of claim 3 , wherein the layer of the electrical conductive material comprises a sheet of aluminum (Al).

5. The system of claim 1 , wherein the electrically conductive element is placed at a distance of less than about 10 cm from the fluidic channel.

6. The system of claim 5 , wherein the electrically conductive element is fully covered on an outer surface of the fluidic channel.

7. The system of claim 1 , wherein a flow rate of the bloodstream through each of the first peristaltic pump and the second peristaltic pump is adjusted at a flow rate defined by:
Flow rate of bloodstream circulation (ml/min)=4×Weight of the cancer patient (Kg).

8. The system of claim 1 , wherein circulating the portion of the bloodstream comprises circulating the portion of the bloodstream at a flow rate between 5 ml/min and 500 ml/min utilizing the at least two peristaltic pumps.

9. The system of claim 1 , wherein circulating the portion of the bloodstream of the cancer patient's body inside the fluidic channel comprises:
extracting the portion of the bloodstream of the cancer patient's body into the fluidic channel; and
re-injecting the portion of the bloodstream from the fluidic channel to the cancer patient's body, wherein extracting the portion of the bloodstream and re-injecting the portion of the bloodstream are done continuously in a cycle.

10. The system of claim 1 , wherein applying the positive electrostatic voltage to the electrically conductive element utilizing the electrostatic charge generator comprises applying a positive electrostatic voltage between 50 V and 50 kV to the electrically conductive element utilizing the electrostatic charge generator.

11. The system of claim 1 , wherein the electrostatic charge generator comprises a Van de Graaff generator.

12. The system of claim 1 , wherein forming deactivated CTCs in the circulating portion of the bloodstream comprises iteratively applying the positive electrostatic voltage to the electrically conductive element daily for between 1 hour and 5 hours for at least three days utilizing the electrostatic charge generator.

Assignees

• Abdolahad Mohammad
• Ghaderinia Mohammad Reza
• Khayamian Mohammad Ali
• Abadijoo Hamed
• Shalileh Shahriar
• Nano Hesgarsazan Salamat Arya

Inventors

• Abdolahad Mohammad
• Ghaderinia Mohammad Reza
• Khayamian Mohammad Ali
• Abadijoo Hamed
• Shalileh Shahriar

Classifications

• A61N1/40

  Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} · CPC title

• A61N1/36002

  Cancer treatment, e.g. tumour · CPC title

• A61N1/205

  for promoting a biological process · CPC title

• A61N1/10

  Applying static electricity (applying ionised gases or vapours A61N1/44) · CPC title

• A61M2205/12

  with interchangeable cassettes forming partially or totally the fluid circuit · CPC title