Body made of titanium or a titanium alloy having a topography for improved blood coagulation and/or cell attachment

Patent metadata

Field	Value
Publication number	US-12207989-B2
Application number	US-202117376592-A
Country	US
Kind code	B2
Filing date	Jul 15, 2021
Priority date	May 26, 2015
Publication date	Jan 28, 2025
Grant date	Jan 28, 2025

Abstract

A body made of titanium or a titanium alloy having a topography for improved blood coagulation and/or cell attachment. The body is obtainable by a process that includes the subsequent steps of: a) etching at least a portion of the surface of the body with a first etching solution including a mineral acid, and b) etching the surface etched under a) with a second etching solution different than the first etching solution, the second etching solution including hydrofluoric acid.

First claim

The invention claimed is:

1. A body having a topography for improved blood coagulation and/or cell attachment, the body being made of titanium or a titanium alloy, the body comprising:
a microscopic topographical formation formed by etching at least a portion of a surface of the body with a first etching solution comprising a mineral acid, and
a sub-microscopic topographical formation on the microscopic topographical formation, the sub-microscopic topographical formation comprising sub-microscopic structures that extend in at least two dimensions to 1,000 nm at most and that are formed on features of the microscopic topographical formation, the sub-microscopic topographical formation being formed by etching the surface including the microscopic topographical formation with a second etching solution after the etching with the first etching solution, said second etching solution being different than the first etching solution and comprising hydrofluoric acid,
wherein:
if hydrofluoric acid is contained in the first etching solution, a concentration of the hydrofluoric acid in the first etching solution is lower than a concentration of hydrofluoric acid in the second etching solution; and
the microscopic topographical formation is defined by at least one surface parameter selected from the group consisting of:
i) an arithmetic mean deviation of the surface in three dimensions (Sa) in a range of from 0.1 μm to 2.0 μm;
ii) a maximum peak to valley height of a profile in three dimensions (St) in a range of from 1.0 μm to 20.0 μm; and
iii) a skewness of the profile in three dimensions (Ssk) in a range of from −0.6 to 1.0.

2. The body according to claim 1 , wherein at least some of the sub-microscopic structures have a shape with at least one straight-line edge, and are sharp-edged and/or jagged.

3. A dental structure comprising the body according to claim 1 , wherein the dental structure is a dental implant or a dental implant abutment.

4. The body according to claim 1 , wherein by the sub-microscopic topographical formation, at least one surface parameter defining the microscopic topographical formation is changed by 50% at most, the at least one surface parameter being selected from the group consisting of: the arithmetic mean deviation of the surface in three dimensions (Sa), the maximum peak to valley height of the profile in three dimensions (St), and the skewness of the profile in three dimensions (Ssk).

5. The body according to claim 1 , wherein the body further includes a macroscopic topographical formation formed in the surface prior to formation of the microscopic topographical formation.

6. The body according to claim 1 , wherein the body is made of a titanium-zirconium alloy.

7. The body according to claim 1 , wherein the concentration of hydrofluoric acid in the second etching solution is in a range from 0.01 vol.-% to 4 vol.-%.

8. The body according to claim 1 , wherein the sub-microscopic topographical formation is formed by performing the etching for a duration in a range of from 0.1 minute to 30 minutes.

9. The body according to claim 1 , wherein the sub-microscopic topographical formation is formed by performing the etching is at a temperature in a range of from 10° C. to 90° C.

10. The body according to claim 1 , wherein the first etching solution comprises a mixture of HCl and H 2 SO 4 .

11. The body according to claim 1 , wherein the body is a dental implant or a dental implant abutment and the topography is provided on at least a portion of the surface of the body that in use is intended to be in contact with bone tissue or soft tissue, respectively.

12. The body according to claim 1 , wherein the etching to form the sub-microscopic topographical formation is a subtractive process in which the second etching solution dissolves and removes material from the surface of the body to alter the topography of the body.

13. The body according to claim 1 , wherein the first etching solution is devoid of hydrofluoric acid.

14. The body according to claim 1 , wherein the etching to form the microscopic topographical formation and the sub-microscopic topographical formation are subtractive processes in which the first etching solution and the second etching solution respectively dissolve and remove material from the surface of the body to alter the topography of the body, the material being dissolved and removed being more than a native oxide layer of the body.

15. The body according to claim 1 , wherein the sub-microscopic topographical formation is of a different topographical scale than the microscopic topographical formation.

Assignees

• Straumann Holding Ag

Inventors

• Berner Simon

Classifications

• A61C8/0006

  Periodontal tissue or bone regeneration (support means for endoprosthetic bone substitute or bone graft implants A61F2/2846) · CPC title

• A61L2430/12

  for dental implants or prostheses · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L27/06 Primary

  Titanium or titanium alloys · CPC title