Hydrogel tablet for relieving alcoholism and protecting the liver as well as preparation process and application thereof

Patent metadata

Field	Value
Publication number	US-12201646-B2
Application number	US-202017277673-A
Country	US
Kind code	B2
Filing date	Nov 20, 2020
Priority date	Nov 26, 2019
Publication date	Jan 21, 2025
Grant date	Jan 21, 2025

Abstract

The present disclosure provides a hydrogel tablet for relieving alcoholism and protecting the liver as well as the preparation process and application thereof. The present disclosure firstly provides a composition with the effects of relieving alcoholism and protecting the liver, which comprises the following components on the basis of weight parts: 20˜40 parts of chitosan, 25˜55 parts of sodium alginate, 3˜20 parts of gelatin, 1˜10 parts of calcium carbonate and 0.05˜0.5 parts of gallic acid. Based on this composition, the present disclosure further provides a hydrogel tablet for relieving alcoholism and protecting the liver. In the present disclosure, chitosan, sodium alginate and calcium carbonate are compounded at an appropriate proportion to form powder particles of chitosan/sodium alginate (shell)-calcium carbonate (core), into which are additionally added gelatin and gallic acid to get a product that is the hydrogel tablet.

First claim

What is claimed is:

1. A composition with the effects of relieving alcoholism and protecting the liver, comprising a powder particle including the following components on the basis of weight parts: 20-40 parts of chitosan, 25-55 parts of sodium alginate, 3-20 parts of gelatin, 1-10 parts of calcium carbonate and 0.05-0.5 parts of gallic acid;
wherein the powder particle comprises chitosan/sodium alginate shell-calcium carbonate core of a core-shell structure encapsulated with a layer gelatin membrane, wherein the chitosan/sodium alginate forms the shell and the calcium carbonate forms the core.

2. The composition according to claim 1 , wherein, it comprises the following components on the basis of weight parts: 25-35 parts of chitosan, 30-50 parts of sodium alginate, 8-15 parts of gelatin, 3-5 parts of calcium carbonate and 0.1-0.3 parts of gallic acid.

3. The composition according to claim 2 , wherein, it comprises the following components on the basis of weight parts: 30 parts of chitosan, 40 parts of sodium alginate, 11 parts of gelatin, 4 parts of calcium carbonate and 0.2 parts of gallic acid.

4. The composition according to claim 1 , wherein, the gelatin is fish gelatin; the fish gelatin is extracted from leftovers of Tilapia, codfish or Tuna.

5. The composition according to claim 1 , wherein, the calcium carbonate has a particle size of 1000-2500 meshes.

6. The composition according to claim 1 , having the effects of relieving alcoholism and protecting the liver.

7. The composition according to claim 6 , wherein, the composition is in the form of preparations comprising tablets, granules, capsules or microspheres.

8. The composition according to claim 7 , wherein, the preparations are tablets, the tablets comprise components of the following mass fractions: 5 wt % of the composition with the effects of relieving alcoholism and protecting the liver, 75 wt % of corn starch, 19 wt % of talc powder, and 1 wt % of magnesium stearate;
wherein by mass fractions, the composition with the effects of relieving alcoholism and protecting the liver comprises 20 parts of chitosan, 25 parts of sodium alginate, 3 parts of gelatin, 1 part of calcium carbonate and 0.05 parts of gallic acid.

9. The composition according to claim 7 , wherein, the preparations are granules, the granules comprise components of the following mass fractions: 15 wt % of the composition with the effects of relieving alcoholism and protecting the liver, 74 wt % of corn starch, 10 wt % of sodium methyl cellulose, and 1 wt % of magnesium stearate;
wherein by mass fractions, the composition with the effects of relieving alcoholism and protecting the liver comprises 40 parts of chitosan, 55 parts of sodium alginate, 20 parts of gelatin, 10 parts of calcium carbonate and 0.5 parts of gallic acid.

10. The composition according to claim 7 , wherein, the preparations are capsules, the capsules comprise components of the following mass fractions: 50 wt % of the composition with the effects of relieving alcoholism and protecting the liver, 20.0 wt % of lactose, 20.0 wt % of corn starch, and 10.0 wt % of talc powder;
wherein by mass fractions, the composition with the effects of relieving alcoholism and protecting the liver comprises 25 parts of chitosan, 30 parts of sodium alginate, 8 parts of gelatin, 3 parts of calcium carbonate and 0.1 parts of gallic acid.

11. The composition according to claim 7 , wherein, the preparations are microspheres, the microspheres comprise components of the following mass fractions: 95 wt % of the composition with the effects of relieving alcoholism and protecting the liver, 2.5 wt % of sodium carboxymethylcellulose, and 2.5 wt % of hyaluronic acid;
wherein by mass fractions, the composition with the effects of relieving alcoholism and protecting the liver comprises 25-35 parts of chitosan, 30-50 parts of sodium alginate, 8-15 parts of gelatin, 3-5 parts of calcium carbonate and 0.1-0.3 parts of gallic acid.

12. The composition according to claim 7 , wherein, the preparations are microspheres, the microspheres comprise components of the following mass fractions: 80 wt % of the composition with the effects of relieving alcoholism and protecting the liver, 10 wt % of sodium carboxymethylcellulose, and 10 wt % of hyaluronic acid;
wherein by mass fractions, the composition with the effects of relieving alcoholism and protecting the liver comprises 30 parts of chitosan, 40 parts of sodium alginate, 11 parts of gelatin, 4 parts of calcium carbonate and 0.2 parts of gallic acid.

13. A hydrogel tablet for relieving alcoholism and protecting a liver, comprising or prepared from the following components on a basis of weight parts: 20-40 parts of chitosan, 25-55 parts of sodium alginate, 3-20 parts of gelatin, 1-10 parts of calcium carbonate and 0.05-0.5 parts of gallic acid; wherein the hydrogel tablet for relieving alcoholism and protecting the liver comprises a powder particle of chitosan/sodium alginate shell-calcium carbonate core of a core-shell structure encapsulated with a layer of gelatin membrane, wherein a chitosan/sodium alginate forms the shell and the calcium carbonate forms the core, wherein the hydrogel tablet for relieving alcoholism and protecting the liver is prepared by a process including the following steps:
(S1) according to the weight parts, chitosan is added into an acidic solution to prepare a chitosan solution, the resulting chitosan solution is adjusted to pH 5.5˜6.0, into which are added the calcium carbonate and the sodium alginate solution in order, treated by vortex vibration and then freeze-dried, to get powder particles of chitosan/sodium alginate shell-calcium carbonate core; the powder particles of chitosan/sodium alginate shell-calcium carbonate core are of a core-shell structure with chitosan/sodium alginate as the shell and with calcium carbonate as the core;
(S2) the gelatin is dissolved in hot water to prepare a gelatin solution, into which is added the gallic acid with stirring to get a gelatin membrane solution; and
(S3) the powder particles of chitosan/sodium alginate shell-calcium carbonate core obtained from S1 are added into the gelatin membrane solution obtained from S2, stirred evenly, freeze-dried, and tableted to get the hydrogel tablet for relieving alcoholism and protecting the liver;
wherein a chronological order of the step S1 and the step S2 is unlimited.

14. The hydrogel tablet for relieving alcoholism and protecting the liver according to claim 13 , wherein, a concentration of the chitosan solution is 1%-3%; the concentration of the sodium alginate solution is 0.5%-1.5%; and the concentration of the gelatin solution is 0.5%-1%.

15. The hydrogel tablet for relieving alcoholism and protecting the liver according to claim 13 , wherein, a time for the vortex vibration in S1 is 10-20 min.

16. The hydrogel tablet for relieving alcoholism and protecting the liver according to claim 13 , wherein, the chitosan solution in S1 is adjusted to pH 5.8.

17. The hydrogel tablet for relieving alcoholism and protecting the liver of claim 13 , wherein the calcium carbonate has a particle size of 1000-2500 meshes.

18. A hydrogel tablet for relieving alcoholism and protecting a liver, comprising the following components on the basis of weight parts: 25-35 parts of chitosan, 30-50 parts of sodium alginate, 8-15 parts of gelatin, 3-5 parts of calcium carbonate and 0.1-0.3 parts of gallic acid; wherein the hydrogel tablet for relieving alcoholism and protecting the liver comprises a powder particle of chitosan/sodium alginate shell-calcium carbonate co

Assignees

• Univ Guangdong Ocean

Inventors

• Hu Zhang
• Lu Sitong
• Kong Songzhi
• Li Sidong
• Zhang Lingyu
• Liao Mingneng
• Li Chengpeng
• Cheng Yu

Classifications

• A61K9/2009

  Inorganic compounds · CPC title

• A61K9/205

  Polysaccharides, e.g. alginate, gums; Cyclodextrin · CPC title

• A61K33/10

  Carbonates; Bicarbonates · CPC title

• A61K31/734

  Alginic acid · CPC title

• A61K9/2095

  Tabletting processes · CPC title