Apparatus and methods for controlled clot aspiration

Patent metadata

Field	Value
Publication number	US-12201311-B2
Application number	US-202418405966-A
Country	US
Kind code	B2
Filing date	Jan 5, 2024
Priority date	Jul 24, 2018
Publication date	Jan 21, 2025
Grant date	Jan 21, 2025

Abstract

A dynamic aspiration method including engaging a distal end of an aspiration catheter against an occlusion in a blood vessel, applying a vacuum through an aspiration lumen of the aspiration catheter using a vacuum source coupled to a proximal end of the aspiration lumen by a connecting tube, whereby portions of the occlusion are drawn into the aspiration lumen, through the connecting tube and into a collection receptacle by the vacuum source, sensing flow through the connecting tube, and automatically generating pressure differentials when a clog or restricted flow is detected.

First claim

The invention claimed is:

1. A dynamic aspiration method comprising:
engaging a distal end of an aspiration catheter against an occlusion in a blood vessel;
applying a vacuum through an aspiration lumen of the aspiration catheter using one or more controllable valves and a vacuum source coupled to a proximal end of the aspiration lumen by a connecting tube, whereby portions of the occlusion are drawn into the aspiration lumen, through the connecting tube and into a collection receptacle by the vacuum source;
generating, via the one or more controllable valves, one or more first pressure pulses within the aspiration catheter or the connecting tube based on a first pressure pulse protocol of a plurality of pressure pulse protocols;
sensing, for each first pressure pulse, a flow rate in the aspiration catheter or the connecting tube to determine a degree of success corresponding to the first pressure pulse; and
automatically modulating the one or more controllable valves in a second pressure pulse protocol based at least in part on the determined degrees of success.

2. The dynamic aspiration method of claim 1 , wherein sensing the flow rate comprises any one or more of differential pressure measurement, magnetic flow measurement, acoustic flow measurement, optical flow measurement, thermal flow measurement, and measurement of circumferential expansion of the connecting tube.

3. The dynamic aspiration method of claim 1 , wherein sensing the flow rate comprises measuring a differential pressure using a first sensor located proximate the vacuum source and a second sensor located in the connecting tube between the vacuum source and the aspiration catheter.

4. The dynamic aspiration method of claim 1 , wherein a pressure source is in fluid communication with the connecting tube.

5. The dynamic aspiration method of claim 4 , wherein the one or more controllable valves comprises a pressure valve between the pressure source and the connecting tube, and a vacuum valve between the vacuum source and the connecting tube.

6. The dynamic aspiration method of claim 5 , wherein one or more of the first pressure pulses are generated by opening and closing the pressure valve and the vacuum valve in sequence.

7. The dynamic aspiration method of claim 1 , further comprising:
sensing a pressure differential in the aspiration catheter or the connecting tube; and
determining a flow state in the aspiration catheter or the connecting tube based on the sensed pressure differential.

8. The dynamic aspiration method of claim 7 , wherein the flow state in the aspiration catheter or the connecting tube is one of a plurality of flow states comprising (1) a restricted flow state, (2) an unrestricted flow state, (3) a clogged flow state, or (4) a partially clogged flow state.

9. The dynamic aspiration method of claim 8 , wherein a magnitude of the pressure differential increases when the flow state is the clogged flow state or the partially clogged flow state.

10. The dynamic aspiration method of claim 8 , wherein a magnitude of the pressure differential is held constant when the flow state is the restricted flow state.

11. The dynamic aspiration method of claim 8 , further comprising:
modulating the one or more controllable valves based on a current flow state corresponding to one of the plurality of flow states.

12. The dynamic aspiration method of claim 1 , wherein the first pressure pulse protocol is predetermined from a library of pressure pulse protocols.

13. The dynamic aspiration method of claim 12 , wherein the library of pressure pulse protocols is associated with specified time periods corresponding to one or more of static aspiration, full aspiration, or occlusion detection.

14. The dynamic aspiration method of claim 1 , further comprising:
selecting one or more of the first pressure pulses that correspond to a particular degree of success; and
repeating, via the one or more controllable valves, the selected first pressure pulses.

15. The dynamic aspiration method of claim 1 , wherein for each first pressure pulse, the corresponding degree of success is commensurate with an amount of increased flow rate after that first pressure pulse.

16. The dynamic aspiration method of claim 1 , wherein a duration of one or more of the plurality of pressure pulse protocols is predetermined based on a pressure in the aspiration catheter or the connecting tube.

17. The dynamic aspiration method of claim 1 , wherein one or more of the plurality of pressure pulse protocols vary from one another in frequency, amplitude, or both.

18. The dynamic aspiration method of claim 1 , wherein one or more of the plurality of pressure pulse protocols are configured to generate successive pressure pulses having increasing amplitude or frequency.

19. The dynamic aspiration method of claim 1 , wherein one or more of the plurality of pressure pulse protocols are configured to generate successive pressure pulses having decreasing amplitude or frequency.

20. The dynamic aspiration method of claim 1 , wherein one or more of the plurality of pressure pulse protocols are configured to generate successive pressure pulses having constant amplitude or frequency.

Assignees

• Penumbra Inc

Inventors

• Teigen Scott
• Loisel Steven
• Pons Stephen
• Tompkins Ben

Classifications

• A61M2205/3344

  Measuring or controlling pressure at the body treatment site · CPC title

• A61B17/00

  Surgical instruments, devices or methods (A61B18/00 takes precedence; dental tools A61C3/00; eye surgery A61F9/007; ear surgery A61F11/20) · CPC title

• A61M1/75

  Intermittent or pulsating suction (A61M1/63, A61M1/772 take precedence) · CPC title

• A61M1/774

  Handpieces specially adapted for providing suction as well as irrigation, either simultaneously or independently · CPC title

• A61B17/32037

  for removing obstructions from inner organs or blood vessels, e.g. for atherectomy · CPC title