Apparatuses, systems, and methods for sample testing

Patent metadata

Field	Value
Publication number	US-12196672-B2
Application number	US-202117302536-A
Country	US
Kind code	B2
Filing date	May 5, 2021
Priority date	May 7, 2020
Publication date	Jan 14, 2025
Grant date	Jan 14, 2025

Abstract

Methods, apparatuses, and systems associated with a sample testing device are provided. For example, an example sample testing device may include a substrate layer defining a bottom surface of the sample testing device, as well as a waveguide disposed on the substrate layer and includes at least one reference channel and at least one sample channel.

First claim

The invention claimed is:

1. A sample testing device comprising:
a substrate layer defining a bottom surface of the sample testing device;
a waveguide disposed on the substrate layer and comprises at least one reference channel and at least one sample channel; and
a processor configured to align a laser source to the waveguide by causing the laser source or an optical element from which a laser emitted by the laser source is refracted or reflected to move in a vertical dimension until detecting a change in a back-reflected power from a surface of the waveguide.

2. The sample testing device of claim 1 , wherein the at least one reference channel is associated with a reference window in an interface layer, and the at least one sample channel is associated with at least one sample window in the interface layer.

3. The sample testing device of claim 2 , wherein the reference window is sealed and contains a reference medium.

4. The sample testing device of claim 2 , wherein the at least one sample window is configured to receive a sample medium.

5. The sample testing device of claim 1 , further comprising:
an analyzer apparatus comprising a slot base and at least one optical window; and
a sensor cartridge fastened to the slot base, wherein the at least one optical window is aligned with one of an input window of the sensor cartridge or an output window of the sensor cartridge, wherein the sensor cartridge comprises the substrate layer and the waveguide.

6. The sample testing device of claim 1 , further comprising:
a sampler component disposed on a top surface of the waveguide, wherein the sampler component comprises an anode element.

7. The sample testing device of claim 1 ,
wherein a characteristic reflectivity of dielectric in which the waveguide is embedded is used as a signal to indicate when the laser is incident on a film; and wherein the processor is further configured to:
cause the laser source or the optical element from which the laser is refracted or reflected to move in a horizontal dimension in a direction indicated by a pattern of light diffracted from gratings formed in the waveguide to either side of a target area for coupling into a main functional waveguide, wherein a position or spatial frequency of the gratings is different on one side of the target area than the other.

8. The sample testing device of claim 1 , wherein the waveguide is configured to receive sample medium comprising non-viral indicator of biological content and viral indicator of biological content, wherein the sample testing device further comprises the processor configured to determine whether a concentration level of the non-viral indicator of biological content satisfies a threshold.

9. The sample testing device of claim 8 , wherein the sample testing device further comprises:
an opening layer disposed on a first surface of the waveguide, wherein the opening layer comprises a first opening at least partially overlapping with a sample opening on the first surface of the waveguide.

10. The sample testing device of claim 9 , further comprising:
a cover layer positioned on top of the opening layer and coupled to the waveguide via at least one sliding mechanism, wherein the cover layer comprises a second opening.

11. The sample testing device of claim 10 , wherein the cover layer is moveable between a first position and a second position, wherein:
when the cover layer is at the first position, the second opening overlaps with the first opening,
when the cover layer is at the second position, the second opening does not overlap with the first opening.

12. The sample testing device of claim 1 , further comprising:
a shell component comprising at least one airflow opening element; and
a base component comprising an air blower element corresponding to the at least one airflow opening element, wherein the air blower element is configured to direct air to the waveguide.

13. The sample testing device of claim 1 , further comprising:
a light source configured to couple light into a bottom surface of the waveguide.

14. The sample testing device of claim 1 , further comprising:
an insulating layer disposed on at least one surface of the waveguide.

15. The sample testing device of claim 14 , further comprising:
at least one sensor configured to control a temperature of the insulating layer.

16. The sample testing device of claim 1 , further comprising:
a thermally controlled waveguide housing encasing the waveguide.

17. The sample testing device of claim 1 , further comprising:
a lens array disposed on the substrate layer, wherein the lens array is configured to direct light to an input edge of the waveguide.

18. The sample testing device of claim 17 , wherein the lens array comprises a compound parabolic concentrator (CPC) lens array.

19. The sample testing device of claim 17 , wherein the lens array comprises a micro CPC lens array.

20. The sample testing device of claim 17 , wherein the lens array comprises an asymmetric CPC lens array.

Assignees

• Hand Held Prod Inc

Inventors

• Venkatarayalu Suresh
• Shafai Moin
• Feng Chen
• Burnett Jennifer
• Isella Giorgio Carlo
• Kester Robert Timothy
• Heppner Benjamin P
• Lopac James A
• Lust Lisa M
• Salit Mary Katherine
• Puckett Matthew Wade
• Mcgraw William

Classifications

• C23C2/51

  Computer-controlled implementation · CPC title

• C02F2209/006

  comprising a software program or a logic diagram · CPC title

• B29C2037/903

  by means of a computer · CPC title

• B23D63/008

  using computer control means · CPC title

• B01D2313/701

  comprising a software program or a logic diagram · CPC title