Anti-inflammatory compounds and methods of use
US-2017096457-A1 · Apr 6, 2017 · US
Anti-inflammatory compounds and methods of use
US12195504B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12195504-B2 |
| Application number | US-202117533320-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 23, 2021 |
| Priority date | May 16, 2014 |
| Publication date | Jan 14, 2025 |
| Grant date | Jan 14, 2025 |
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- Title
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Abstract
Official abstract text for this publication.
Methods of treating or inhibiting inflammation in a subject include administering an anti-inflammatory protein to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, SEQ ID NO: 11, or fragments thereof. Isolated polypeptides, nucleic acids, and recombinant vectors including a nucleic acid encoding the anti-inflammatory protein (such as a nucleic acid encoding a protein with at least 80% sequence identity to SEQ ID NO: 1, SEQ ID NO: 11, or fragments thereof) operably linked to a heterologous promoter are also disclosed.
First claim
Opening claim text (preview).
We claim: 1. A method of treating inflammatory bowel disease, Hirschsprung's associated enterocolitis, irritable bowel syndrome, or necrotizing enterocolitis in a subject, comprising administering to the subject a polypeptide comprising: an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 11; or an amino acid sequence comprising amino acids 1-188 of SEQ ID NO: 11, amino acids 21-188 of SEQ ID NO: 11, or amino acids 189-330 of SEQ ID NO: 11. 2. The method of claim 1 , wherein the polypeptide consists of: the amino acid sequence of SEQ ID NO: 11; or the amino acid sequence of amino acids 1-188 of SEQ ID NO: 11, amino acids 21-188 of SEQ ID NO: 11, or amino acids 189-330 of SEQ ID NO: 11. 3. The method of claim 1 , wherein the amount of the polypeptide administered to the subject is about 1 mg to about 5 g. 4. The method of claim 1 , wherein the polypeptide is administered to the subject daily, weekly, or monthly. 5. The method of claim 1 , further comprising administering one or more of a non-steroidal anti-inflammatory drug (NSAID), corticosteroid, or disease-modifying antirheumatic drug (DMARD) to the subject. 6. The method of claim 1 , wherein the inflammatory bowel disease is ulcerative colitis or Crohn's disease.
Assignees
Inventors
Classifications
from animals; from humans · CPC title
Vectors or expression systems specially adapted for E. coli · CPC title
- A61P29/00Primary
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
- C07K14/4702Primary
Regulators; Modulating activity · CPC title
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- What does patent US12195504B2 cover?
- Methods of treating or inhibiting inflammation in a subject include administering an anti-inflammatory protein to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, SEQ ID NO: 11, or fragments thereof. Isolated polypeptides, nucleic acids, and recombinant vectors including a nucleic acid encoding the anti-inflam…
- Who is the assignee on this patent?
- Univ Oregon
- What technology area does this patent fall under?
- Primary CPC classification A61P29/00. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).