Electrode leads having multi-application nerve cuffs and associated systems and methods

Patent metadata

Field	Value
Publication number	US-12194290-B2
Application number	US-202117463611-A
Country	US
Kind code	B2
Filing date	Sep 1, 2021
Priority date	Sep 2, 2020
Publication date	Jan 14, 2025
Grant date	Jan 14, 2025

Abstract

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

First claim

We claim:

1. An electrode lead, comprising:
an elongate lead body having a proximal end and a distal end;
a biologically compatible, elastic, electrically insulative cuff body affixed to the distal end of the lead body, the cuff body being configured to be circumferentially disposed around a nerve, having a pre-set furled state that defines an inner lumen with a longitudinal axis, being movable to an unfurled state, and defining a length, a length direction, a width in the unfurled state that is greater than the length, and a width direction;
first and second electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that both of the first and second electrically conductive contacts extend more than 360° around the longitudinal axis of the cuff body inner lumen when the cuff body is in the pre-set furled shape;
a plurality of intermediate electrically conductive contacts carried by the cuff body that are shorter than the first and second electrically conductive contacts in the width direction, are spaced from one another in the width direction and are located between the first and second electrically conductive contacts; and
a plurality of electrical conductors extending through the lead body from at least some of the electrically conductive contacts to the proximal end of the lead body.

2. An electrode lead as claimed in claim 1 , further comprising:
a plurality of lead connector terminals at the proximal end of the lead body that are connected to the plurality of electrical conductors.

3. An electrode lead as claimed in claim 1 , wherein
the first and second electrically conductive contacts are the same length.

4. An electrode lead as claimed in claim 1 , wherein
the first and second electrically conductive contacts are the only two electrically conductive contacts that extend more than 360° around the longitudinal axis of the cuff body inner lumen when the cuff body is in the pre-set furled shape.

5. An electrode lead as claimed in claim 1 , wherein
the first and second electrically conductive contacts are parallel to one another.

6. An electrode lead as claimed in claim 1 , wherein
the plurality of intermediate electrically conductive contacts comprises at least five intermediate electrically conductive contacts.

7. An electrode lead as claimed in claim 1 , wherein
all of the intermediate electrically conductive contacts are equidistant from the first and second electrically conductive contacts.

8. An electrode lead as claimed in claim 1 , wherein
not all of the intermediate electrically conductive contacts are equidistant from the first and second electrically conductive contacts.

9. An electrode lead as claimed in claim 1 , wherein
the cuff body includes a stimulation region on which all of the contacts are located and a compression region that wraps around the stimulation region when the cuff body is in the pre-set furled shape.

10. A method, comprising:
placing the cuff body of the electrode lead claimed in claim 1 on either one of the hypoglossal nerve (HGN) trunk and the branch of the HGN that is responsible for protruding the tongue (HGN GM branch);
applying stimulation energy to the HGN trunk with at least some of the electrically conductive contacts in instances where the cuff body is on the HGN trunk; and
applying stimulation energy to the HGN GM branch with at least some of the electrically conductive contacts in instances where the cuff body is on the HGN GM branch.

11. A method as claimed in claim 10 , wherein
applying stimulation energy to the HGN GM branch comprises applying stimulation energy to the HGN GM branch with all of the intermediate electrically conductive contacts and returning the stimulation energy with at least one of the first and second electrically conductive contacts.

12. A method as claimed in claim 10 , wherein
applying stimulation energy to the HGN trunk comprises applying stimulation energy to the HGN trunk with at least one of the intermediate electrically conductive contacts and returning the stimulation energy with at least one of the intermediate electrically conductive contacts.

13. A method as claimed in claim 10 , wherein
applying stimulation energy to the HGN trunk comprises applying stimulation energy to the HGN trunk with at least one of the intermediate electrically conductive contacts and returning the stimulation energy with at least one of the first and second electrically conductive contacts and at least one of the intermediate electrically conductive contacts.

Assignees

• The Alfred E Mann Foundation For Scient Research

Inventors

• Dearden Brian Ralph
• Shelton Brian M
• Talbot Neil

Classifications

• A61N1/3605

  Implantable neurostimulators for stimulating central or peripheral nerve system · CPC title

• A61N1/0556 Primary

  Cuff electrodes · CPC title

• A61N1/36078

  Inducing or controlling sleep or relaxation (non-implantable stimulator A61M21/00) · CPC title