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Integrated human organ-on-chip microphysiological systems
US12187997B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12187997-B2 |
| Application number | US-202318346165-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 30, 2023 |
| Priority date | Dec 9, 2011 |
| Publication date | Jan 7, 2025 |
| Grant date | Jan 7, 2025 |
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- Title
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- Abstract
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Abstract
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The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
First claim
Opening claim text (preview).
What is claimed is: 1. A device, comprising Sertoli and Leydig cells on a first side of a membrane, and endothelial cells on a second side of said membrane. 2. The device of claim 1 , wherein said Sertoli and Leydig cells are human cells. 3. The device of claim 1 , wherein said membrane is an ECM-coated membrane. 4. The device of claim 3 , wherein said ECM-coated membrane is coated with laminin. 5. The device of claim 3 , wherein said ECM-coated membrane is coated with type IV collagen. 6. The device of claim 1 , wherein said endothelial cells are human endothelial cells. 7. A method comprising: a) providing Sertoli and Leydig cells on a first side of a membrane in a first channel, and endothelial cells on a second side of said membrane in a second channel; and b) culturing said cells. 8. The method of claim 7 , wherein said Sertoli and Leydig cells are human cells. 9. The method of claim 7 , wherein said membrane is an ECM-coated membrane. 10. The method of claim 9 , wherein said ECM-coated membrane is coated with laminin. 11. The method of claim 9 , wherein said ECM-coated membrane is coated with type IV collagen. 12. The method of claim 1 , wherein said endothelial cells are human endothelial cells.
Assignees
Inventors
Classifications
Reaction vessels connected in series or in parallel (combinations of bioreactors with other apparatus, C12M43/00) · CPC title
of vertebrates · CPC title
with provisions specially adapted for transporting · CPC title
for organ perfusion · CPC title
Preservation or perfusion media · CPC title
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Frequently asked questions
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- What does patent US12187997B2 cover?
- The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
- Who is the assignee on this patent?
- Harvard College
- What technology area does this patent fall under?
- Primary CPC classification C12M23/16. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).