Radiotherapy dose analysis methods and systems

Patent metadata

Field	Value
Publication number	US-12186592-B2
Application number	US-202117563882-A
Country	US
Kind code	B2
Filing date	Dec 28, 2021
Priority date	Dec 28, 2021
Publication date	Jan 7, 2025
Grant date	Jan 7, 2025

Abstract

Dose analysis radiotherapy systems and methods for determine delivered radiotherapy dose, dose rate, irradiation time and position information and planned radiotherapy dose, dose rate, irradiation time and position information. The dose analysis systems and methods further compare the as delivered dose, dose rate, irradiation time and position information to the planned dose, dose rate, irradiation time and position information to generate a graphical representation of one or more of the delivered dose, dose rate, irradiation time and position information versus planned dose, dose rate, irradiation time and position information.

First claim

What is claimed is:

1. A radiotherapy dose analysis system comprising:
a delivery information extractor configured to determine delivered radiotherapy treatment information including dose, time and position information;
a physics dose model engine configured to determine planned radiotherapy treatment information including dose, dose rate, time and position information from a radiotherapy treatment plan; and
a dose/dose rate comparison engine configured to
receive calibration information and reconstruct a dose rate of the delivered radiotherapy treatment information from the calibration information and the dose, time and position information of the delivered radiotherapy treatment information,
reconstruct dose and dose rate information in two or three dimensions to compare the dose rate and the dose, time and position information of the delivered radiotherapy treatment information to the dose, dose rate, time and position information of the planned radiotherapy treatment plan and
generate a graphical representation of one or more of the dose rate and dose, dose rate, time and position information of the delivered radiotherapy treatment information versus the dose, dose rate, time and position information of the planned radiotherapy treatment plan.

2. The radiotherapy dose analysis system of claim 1 , wherein the delivered radiotherapy treatment information including dose, time and position information is determined from one or more treatment delivery records.

3. The radiotherapy dose analysis system of claim 1 , wherein the delivery information extractor is further configured to utilize statistical parameters including one or more of a delivered dose threshold and a dose rate threshold to extract fractions of voxels in two or three dimensions that are above one or more of the dose delivered threshold and dose rate threshold.

4. The radiotherapy dose analysis system of claim 2 , further comprising:
an array of ionization detectors; and
a processor configured to sample charge values between ionization chamber plates of the array of ionization detectors to determine dose, time and position parameters for storage in the one or more treatment delivery records.

5. The radiotherapy dose analysis system of claim 1 , wherein the physics dose model engine is further configured to determine the planned radiotherapy treatment information including the dose, dose rate, time and position information from patient physics information.

6. The radiotherapy dose analysis system of claim 5 , wherein:
the radiotherapy treatment plan is generated by a radiotherapy planning system; and
the patient physics information is generated by a patient physics system providing one or more of a Computer Tomography (CT) scan image, a Magnetic Resonance Imaging (MRI) scan image, a Positron-Emission Tomography (PET) image and an ultrasound image.

7. The radiotherapy dose analysis system of claim 1 , wherein radiotherapy treatment of the delivered radiotherapy treatment information and the planned radiotherapy treatment information comprises a flash radiotherapy treatment.

8. A radiotherapy dose analysis method comprising:
determining delivered radiotherapy treatment information including dose, irradiation time and position information;
determining planned radiotherapy treatment information including dose, dose rate, irradiation time and position information from a radiotherapy treatment plan and patient physics records;
receiving calibration information;
determining a delivered dose rate from the calibration information and the delivered radiotherapy treatment information including the dose, irradiation time and position information;
comparing the delivered dose rate and the delivered radiotherapy treatment information including the dose, irradiation time and position information to the dose, dose rate, irradiation time and position information of the radiotherapy treatment plan to generate a graphical representation of one or more of the delivered dose rate and the delivered radiotherapy treatment information including the dose, irradiation time and position information versus the dose, dose rate, irradiation time and position information of the planned radiotherapy treatment information; and
outputting the graphical representation of one or more of the delivered dose rate and the delivered radiotherapy treatment information including the dose, irradiation time and position information versus the dose, dose rate, irradiation time and position information of the planned radiotherapy treatment information.

9. The radiotherapy dose analysis method according to claim 8 , wherein the radiotherapy treatment of the delivered radiotherapy treatment information and the planned radiotherapy treatment information comprises a flash radiotherapy treatment.

10. The radiotherapy dose analysis method according to claim 8 , wherein:
the dose rate of the planned radiotherapy treatment information is determined from the dose, irradiation time and position information of planned radiotherapy treatment information.

11. The radiotherapy dose analysis method according to claim 10 , wherein the delivered radiotherapy treatment information is determined from one or more treatment delivery records of a radiotherapy delivery system.

12. The radiotherapy dose analysis method according to claim 8 , further comprising:
extracting fractions of voxels in two or three dimensions that are above one or more of a delivered dose threshold and a dose rate threshold from statistical parameters including one or more of the delivered dose threshold and the dose rate threshold.

13. The radiotherapy dose analysis method according to claim 8 , further comprising determining the planned radiotherapy treatment information including the dose, dose rate, irradiation time and position information from patient physics information.

14. Computing device executable instructions stored on one or more computing device readable media that when executed by one or more processors perform a radiotherapy dose analysis method comprising:
determining delivered radiotherapy treatment information including dose, irradiation time and position information;
determining planned radiotherapy treatment information including dose, dose rate, irradiation time and position information from a radiotherapy treatment plan and patient physics records;
receiving calibration information;
determining a delivered dose rate from the calibration information and the delivered radiotherapy treatment information including the dose, irradiation time and position information;
comparing the delivered dose rate and the delivered radiotherapy treatment information including the dose, irradiation time and position information to the dose, dose rate, irradiation time and position information of the radiotherapy treatment plan to generate a graphical representation of one or more of the delivered dose rate and the delivered radiotherapy treatment information including the dose, irradiation time and position information versus the dose, dose rate, irradiation time and position information of the planned radiotherapy treatment information; and
outputting the graphical representation of one or more of the delivered dose rate and the delivered radiotherapy treatment information including the dose, irradiation time and position information versus the dose, dose rate, irradiation time and position information of the planned radiotherapy treatment information.

15. The computing device executable instructions stored on the one or more computing device readable media that when executed by the one or more processors perform the rad

Assignees

• Varian Medical Systems Particle Therapy Gmbh & Co Kg
• Varian Med Sys Inc

Inventors

• Spiessens Sylvie
• Folkerts Michael
• Abel Eric
• HUTH Isabel
• Pfeiler Tina
• Lansonneur Pierre

Classifications

• A61N5/1075

  for testing, calibrating, or quality assurance of the radiation treatment apparatus · CPC title

• A61N5/1039

  using functional images, e.g. PET or MRI · CPC title

• A61N2005/1074

  Details of the control system, e.g. user interfaces · CPC title

• A61N5/1045

  using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT · CPC title

• A61N5/1071 Primary

  for verifying the dose delivered by the treatment plan · CPC title