Composition for preventing, alleviating, or treating allergic skin disease comprising as active ingredient extract of gardenia fruit from which pigment is removed

Patent metadata

Field	Value
Publication number	US-12186356-B2
Application number	US-201917258253-A
Country	US
Kind code	B2
Filing date	Jul 10, 2019
Priority date	Jul 10, 2018
Publication date	Jan 7, 2025
Grant date	Jan 7, 2025

Abstract

The present invention relates to a composition for preventing, alleviating, or treating allergic skin diseases comprising, as an active ingredient, an extract of gardenia fruit from which pigment is removed, and since the extract of gardenia fruit from which pigment is removed is more effective for allergic skin diseases compared to an extract of gardenia fruit from which pigment is not removed, the composition can be very advantageously used for allergic skin diseases, in particular, atopic dermatitis.

First claim

What is claimed is:

1. A method for treating an allergic disease, the method comprising administering to a subject in need thereof a composition comprising, as an active ingredient, an extract of gardenia fruit from which pigment is removed,
wherein the pigment is crocin.

2. The method of claim 1 , wherein the allergic disease is selected from the group consisting of atopic dermatitis, allergic dermatitis, contact dermatitis, skin hives, itch, insect allergy, food allergy, drug allergy, edema, anaphylaxis, allergic rhinitis, asthma, allergic conjunctivitis, and a combination thereof.

3. The method of claim 1 , wherein the extract of gardenia fruit from which pigment is removed is produced by:
carrying out first extraction by adding an extraction solvent to gardenia fruit followed by filtration to obtain a first filtrate;
adding an extraction solvent to residues remained after obtaining the first filtrate to obtain a second filtrate;
mixing the first filtrate with the second filtrate;
adding activated carbon for allowing pigment of gardenia fruit extract to get adsorbed onto the activated carbon;
removing the activated carbon; and
obtaining the extract of gardenia fruit from which the pigment is removed by filtration, concentration, and drying.

4. The method of claim 1 , wherein the composition is a pharmaceutical composition.

5. The method of claim 1 , wherein the composition is included in a quasi-pharmaceutical product.

6. The method of claim 5 , wherein the quasi-pharmaceutical product is a skin preparation for external use.

7. The method of claim 1 , wherein the composition is a functional health food composition.

Assignees

• Korea Inst Oriental Medicine

Inventors

• Kim Ho Kyoung
• Park Sun Haeng
• Jang Seol

Classifications

• B01D15/125

  Pre-filtration · CPC title

• B01D11/0288

  Applications, solvents · CPC title

• A61K2236/53

  Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization · CPC title

• A61K2236/51

  Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying · CPC title

• A61K2236/39

  Complex extraction schemes, e.g. fractionation or repeated extraction steps · CPC title