Fasting-mimicking diet (FMD) but not water-only fasting promotes reversal of inflammation and IBD pathology

Patent metadata

Field	Value
Publication number	US-12186352-B2
Application number	US-202217982067-A
Country	US
Kind code	B2
Filing date	Nov 7, 2022
Priority date	Mar 15, 2018
Publication date	Jan 7, 2025
Grant date	Jan 7, 2025

Abstract

A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.

First claim

What is claimed is:

1. A method for treating autoimmune and/or inflammatory disease, the method comprising:
identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease; and
administering a fasting mimicking diet for a first predetermined time period, the fasting mimicking diet providing the subject with at most 50% to 75% of the subject's normal caloric intake, wherein a probiotic composition is administered to the subject during the first predetermined time period, the probiotic composition comprising:
one or more bacterial components selected from the group consisting of Bacteroides acidifaciens, Bifidobacterium choerinum , and combinations thereof; and
a protective component that stabilizes the one or more bacterial components.

2. The method of claim 1 wherein the fasting mimicking diet provides at most 50% of a subject's normal caloric intake and at least 5% of the subject's normal caloric intake.

3. The method of claim 1 wherein the fasting mimicking diet provides at most 1500 kcal/day and at least 800 kcal/day.

4. The method of claim 1 wherein the fasting mimicking diet is administered for 2 or more cycles.

5. The method of claim 1 , wherein the one or more bacterial components further comprises gut microbiota strains isolated from genera selected from the group consisting of Lactobacillus, Allobaculum, Bifidobacterium , and combinations thereof.

6. The method of claim 5 wherein each bacterial component is present in an amount from about 10 3 to about 10 14 CFU/g.

7. The method of claim 1 , wherein the protective component is selected from the group consisting of protective carriers, protective coating, and protective encapsulants.

8. The method of claim 1 , wherein the fasting mimicking diet is provided from a meal package that includes daily meal portions that provide less than 40 grams of sugar for day 1, less than 30 grams of sugar for days 2 to 5 and any remaining days, less than 28 grams of protein for day 1, less than 18 grams of protein for days 2 to 5 and any remaining days, 20-30 grams of monounsaturated fats or more to reach a desired caloric intake for day 1, 6-10 grams of polyunsaturated fats or more to reach a desired caloric intake for day 1, 2-12 grams of saturated fats or more to reach a desired caloric intake for day 1, 10-15 grams of monounsaturated fats or more to reach a desired caloric intake for days 2 to 5 and any remaining days, 3-5 grams of polyunsaturated fats or more to reach a desired caloric intake for days 2 to 5 and any remaining days, 1-6 grams of saturated fats or more to reach a desired caloric intake for days 2 to 5 and any remaining days.

9. The method of claim 1 wherein the autoimmune and/or inflammatory disease is selected from the group consisting of Crohn's disease, ulcerative colitis, irritable bowel syndrome, celiac disease, microscopic colitis, and Behcet disease.

Assignees

• Univ Southern California

Inventors

• Longo Valter D
• Wei Min
• Rangan Priya

Classifications

• A61K36/07

  Basidiomycota, e.g. Cryptococcus · CPC title

• A61K36/185

  Magnoliopsida (dicotyledons) · CPC title

• A23B2/92

  Freeze drying · CPC title

• A61K2035/115

  Probiotics · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title