Method for evaluating an angiographic dual-energy computed tomography dataset, evaluation facility and non-transitory electronically readable data carrier

Patent metadata

Field	Value
Publication number	US-12186113-B2
Application number	US-202218057821-A
Country	US
Kind code	B2
Filing date	Nov 22, 2022
Priority date	Nov 29, 2021
Publication date	Jan 7, 2025
Grant date	Jan 7, 2025

Abstract

One or more example embodiments provides a method for evaluating an angiographic dual-energy computed tomography dataset recorded using a contrast agent comprising iodine to determine a quantitative calcium score.

First claim

The invention claimed is:

1. A method for evaluating an angiographic dual-energy computed tomography dataset recorded using a contrast agent comprising iodine, the angiographic dual-energy computed tomography dataset including an image vector for each pixel, the image vector being formed by a first attenuation value assigned to a high-energy spectrum and a second attenuation value assigned to a low-energy spectrum, the method comprising:
specifying a calcium base vector and an iodine base vector in a two-dimensional dual-energy space spanned by the first attenuation value as an x-axis and the second attenuation value as a y-axis, a base material decomposition being based on the two-dimensional dual-energy space;
projecting all image vectors below a straight line in the dual-energy space onto the straight line to determine a modified dual-energy computed tomography dataset, the straight line being defined by the calcium base vector;
performing the base material decomposition of the modified dual-energy computed tomography dataset to determine a calcium image dataset; and
determining a quantitative calcium score from the calcium image dataset.

2. The method of claim 1 , wherein the base material decomposition is restricted to a permissible attenuation value range in the dual-energy space, wherein the determining the calcium image dataset outside of the permissible attenuation value range includes,
determining mixed image attenuation values from the first attenuation value and the second attenuation value.

3. The method of claim 2 , wherein the permissible attenuation value range includes non-negative attenuation values.

4. The method of claim 3 , wherein the determining the quantitative calcium score includes,
selecting an amount of the calcium base vector for setting a calcium contrast based on calibration data.

5. The method of claim 4 , wherein the selecting the amount of the calcium base vector includes,
recording calibration datasets with contrast agent for at least one calibration object, wherein a reference value of the quantitative calcium score is known for the calibration object or is determined, and
selecting the amount to be set such that an evaluation value of at least one calibration dataset corresponds to the reference value.

6. The method of claim 2 , wherein the determining the quantitative calcium score includes,
selecting an amount of the calcium base vector for setting a calcium contrast based on calibration data.

7. The method of claim 6 , wherein the selecting the amount of the calcium base vector includes,
recording calibration datasets with contrast agent for at least one calibration object, wherein a reference value of the quantitative calcium score is known for the calibration object or is determined, and
selecting the amount to be set such that an evaluation value of at least one calibration dataset corresponds to the reference value.

8. The method of claim 6 , further comprising:
selecting weightings of the first attenuation value and the second attenuation value are to determine a mixed image attenuation value as a function of the selected amount when a mixed image outside of the permissible attenuation value range is used.

9. The method of claim 2 , wherein the determining the quantitative calcium score determines the quantitative calcium score based on a user-side selection of calcifications in a displayed calcium image dataset.

10. The method of claim 1 , wherein the determining the quantitative calcium score includes,
selecting an amount of the calcium base vector for setting a calcium contrast based on calibration data.

11. The method of claim 10 , wherein the selecting the amount of the calcium base vector includes,
recording calibration datasets with contrast agent for at least one calibration object, wherein a reference value of the quantitative calcium score is known for the calibration object or is determined, and
selecting the amount to be set such that an evaluation value of at least one calibration dataset corresponds to the reference value.

12. The method of claim 10 , further comprising:
selecting weightings of the first attenuation value and the second attenuation value are to determine a mixed image attenuation value as a function of the selected amount when a mixed image outside of a permissible attenuation value range is used.

13. The method of claim 10 , wherein at least one of the determining the quantitative calcium score includes determining an Agatston score is determined as the quantitative calcium score, or
evaluating the dual-energy computed tomography dataset for lesions in a coronary vascular tree, the dual-energy computed tomography dataset being a coronary computed tomography angiography dataset.

14. The method of claim 13 , further comprising:
recording the dual-energy computed tomography dataset using at least one of two different transmit spectra of at least one x-ray source or a photon-counting x-ray detector.

15. The method of claim 1 , wherein the determining the quantitative calcium score determines the quantitative calcium score based on a user-side selection of calcifications in a displayed calcium image dataset.

16. The method of claim 1 , wherein at least one of
the determining the quantitative calcium score includes determining an Agatston score is determined as the quantitative calcium score, or
evaluating the dual-energy computed tomography dataset for lesions in a coronary vascular tree, the dual-energy computed tomography dataset being a coronary computed tomography angiography dataset.

17. The method of claim 1 , further comprising:
recording the dual-energy computed tomography dataset using at least one of two different transmit spectra of at least one x-ray source or a photon-counting x-ray detector.

18. A non-transitory computer readable medium including instructions that, when executed by an evaluation facility, cause the evaluation facility to perform the method of claim 1 .

19. A non-transitory electronically readable data carrier including instructions that, when executed by an evaluation facility, cause the evaluation facility to perform the method of claim 1 .

20. An evaluation facility comprising:
a first interface configured to receive an angiographic dual-energy computed tomography dataset recorded using a contrast agent comprising iodine, the angiographic dual-energy computed tomography dataset comprises an image vector for each pixel, the image vector being formed by a first attenuation value assigned to a high-energy spectrum and a second attenuation value assigned to a low-energy spectrum;
a storage means storing a calcium base vector and an iodine base vector in a two-dimensional dual-energy space spanned by the first attenuation value as an x-axis and the second attenuation value as a y-axis, a base material decomposition being based on the two-dimensional dual-energy space;
a modification unit configured to determine a modified dual-energy computed tomography dataset by projecting all image vectors in the dual-energy space below a straight line onto the straight line, the straight line defined by the calcium base vector;
a base material decomposition unit configured to perform the base material decomposition of the modified dual-energy computed tomography dataset to determine a calcium image dataset;
a determination unit configured to determine a quantitative calcium score from the calcium image dataset; and
a second interface configured to output the quantitative calcium score.

Assignees

• Siemens Healthineers Ag

Inventors

• Schmidt Bernhard
• Allmendinger Thomas
• Nowak Tristan

Classifications

• A61B6/482

  involving multiple energy imaging · CPC title

• A61B6/4241

  using energy resolving detectors, e.g. photon counting · CPC title

• A61B6/582

  Calibration · CPC title

• A61B6/48

  Diagnostic techniques (A61B6/022, A61B6/025 A61B6/032, A61B6/037 take precedence) · CPC title

• A61B6/032 Primary

  Transmission computed tomography [CT] · CPC title