Diagnosis support program, diagnosis support system, and diagnosis support method

Patent metadata

Field	Value
Publication number	US-12183449-B2
Application number	US-201917433566-A
Country	US
Kind code	B2
Filing date	Dec 25, 2019
Priority date	Feb 28, 2019
Publication date	Dec 31, 2024
Grant date	Dec 31, 2024

Abstract

A diagnosis support program causes a computer to execute a derivation procedure of deriving, on the basis of a first pathological image corresponding to a first affected tissue, history information regarding a history of viewing the first pathological image, and diagnostic information for the first affected tissue corresponding to the first pathological image, diagnosis support information for supporting diagnosis of a second pathological image corresponding to a second affected tissue to be diagnosed.

First claim

The invention claimed is:

1. A non-transitory computer readable medium storing a program which, when executed, causes a computer to perform processing comprising:
a derivation procedure of deriving, on a basis of a first pathological image corresponding to a first affected tissue wherein the first pathological image comprises a plurality of pixels, history information regarding a history of viewing the first pathological image comprising a number of times the first pathological image was viewed and a length of time over which the first pathological image has been viewed and a position of a portion of the first pathological image that was enlarged and displayed, and diagnostic information for the first affected tissue corresponding to the first pathological image, diagnosis support information for supporting diagnosis of a second pathological image corresponding to a second affected tissue to be diagnosed; and
a learning procedure comprising assigning at least one of the plurality of pixels an attention value based on a magnification ratio of the at least one pixel, a viewing time of the at least one pixel, a number of times the at least one pixel was viewed, generating a map image comprising the attention values corresponding to the plurality of pixels, and determining the diagnostic information for the first affected tissue corresponding to the first pathological image by identifying a first portion of the first pathological image having a positive result and a second portion of the first pathological image having a negative result.

2. The diagnosis support program according to claim 1 , wherein
the derivation procedure derives information regarding viewing as the diagnosis support information.

3. The diagnosis support program according to claim 1 , wherein
the first pathological image is an entire image obtained by imaging the entire first affected tissue, and
the history information is position information indicating a position where the first pathological image has been viewed.

4. The diagnosis support program according to claim 3 , wherein
the history information is position information indicating a position where the first pathological image has been viewed, and information indicating a time or the number of times the first pathological image has been viewed.

5. The diagnosis support program according to claim 1 , wherein
the first pathological image is an image constituted by a partial image corresponding to each region of the first affected tissue, and
the history information is partial image information indicating a viewed partial image among the partial images corresponding to the regions.

6. The diagnosis support program according to claim 1 , wherein
the derivation procedure derives the diagnosis support information on a basis of an attention region of the second pathological image estimated from the history information.

7. The diagnosis support program according to claim 6 , wherein
the derivation procedure derives the diagnosis support information on a basis of the history information, assuming that a region with a larger display magnification is an attention region with a higher degree of attention, a region with a longer viewing time is an attention region with a higher degree of attention, or a region with a larger number of times of viewing is an attention region with a higher degree of attention.

8. The diagnosis support program according to claim 1 , wherein
the diagnostic information is information regarding whether a lesion site has been found, a type of the lesion site, or a degree of progression of the lesion site.

9. The diagnosis support program according to claim 1 , wherein the learning procedure learning an association among the first pathological image, the history information, and the diagnostic information, and
wherein the derivation procedure derives the diagnosis support information by using a result of learning by the learning procedure.

10. The diagnosis support program according to claim 9 , wherein
the learning procedure learns, in association with each other, the diagnostic information that indicates a positive diagnosis result and the history information corresponding to the diagnostic information.

11. The diagnosis support program according to claim 9 , wherein
the learning procedure learns, in association with each other, the diagnostic information that indicates a negative diagnosis result and the history information corresponding to the diagnostic information.

12. The diagnosis support program according to claim 11 , wherein
the learning procedure learns regions other than an attention region in the second pathological image as the diagnostic information that indicates a negative diagnosis result.

13. The diagnosis support program according to claim 1 , wherein
the derivation procedure derives the diagnosis support information on a basis of history information regarding a viewing history corresponding to the first pathological image having a similarity to the second pathological image higher than a threshold value, or the first pathological image having a degree of correlation with the second pathological image higher than a threshold value.

14. A diagnosis support system comprising:
a microscope; and
a derivation device that derives diagnosis support information, which is information for supporting diagnosis,
wherein the derivation device derives, on a basis of a first pathological image corresponding to a first affected tissue, history information regarding a history of viewing the first pathological image comprising a number of times the first pathological image was viewed and a length of time over which the first pathological image has been viewed and a position of a portion of the first pathological image that was enlarged and displayed, and diagnostic information for the first affected tissue, diagnosis support information for supporting diagnosis of a second pathological image corresponding to a second affected tissue to be diagnosed that has been imaged by the microscope; and a learning procedure,
wherein the learning procedures assigns at least one of the plurality of pixels an attention value based on a magnification ratio of the at least one pixel, a viewing time of the at least one pixel, a number of times the at least one pixel was viewed, generates a map image comprising the attention values corresponding to the plurality of pixels, and determines the diagnostic information for the first affected tissue corresponding to the first pathological image by identifying a first portion of the first pathological image having a positive result and a second portion of the first pathological image having a negative result.

15. The diagnosis support system according to claim 14 , wherein
the diagnosis support system further includes a display control device, and
the display control device controls, on a basis of the diagnosis support information, an attention region, which is a region estimated to influence a diagnosis, to be visibly superimposed and displayed on the second pathological image.

16. The diagnosis support system according to claim 15 , wherein
the display control device changes a display mode of the attention region in accordance with a degree of influence on the diagnosis or a degree of reliability of the diagnosis support information on a basis of the diagnosis support information.

17. The diagnosis support system according to claim 15 , wherein
the display control device performs a control to display a part of an image of the second affected tissue corresponding to the attention reg

Assignees

• Sony Group Corp
• Sony Corp

Inventors

• Aisaka Kazuki
• Kunihiro Takeshi
• Yamane Kenji
• Watanabe Shinji

Classifications

• G06T2207/30096

  Tumor; Lesion · CPC title

• G06T2207/30024

  Cell structures in vitro; Tissue sections in vitro · CPC title

• G06T2207/20081

  Training; Learning · CPC title

• G06T2207/10056

  Microscopic image · CPC title

• G06T7/0012

  Biomedical image inspection · CPC title