Devices and methods for non-invasive nerve stimulation

Patent metadata

Field	Value
Publication number	US-12179012-B2
Application number	US-202217713832-A
Country	US
Kind code	B2
Filing date	Apr 5, 2022
Priority date	Aug 19, 2010
Publication date	Dec 31, 2024
Grant date	Dec 31, 2024

Abstract

Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.

First claim

The invention claimed is:

1. A method for treating a disorder in a patient, the method comprising:
positioning a device adjacent an outer skin surface of the patient;
generating an electrical impulse within the device; and
transmitting the electrical impulse from the device through the outer skin surface to a target nerve within the patient, wherein the electrical impulse comprises burst periods and constant periods, wherein each burst period includes 4 to 10 pulses and has a duration between 800 microseconds and 2,000 microseconds, wherein the pulses alternate between a positive voltage and a negative voltage within each burst period.

2. The method of claim 1 further comprising positioning an electrode near the outer skin surface and applying a voltage to the electrode to generate an electric field.

3. The method of claim 2 further comprising varying the voltage such that the electric field emitted by the electrode includes the burst periods and the constant periods.

4. The method of claim 2 , wherein the electric field generated during the constant periods has a magnitude of about zero.

5. The method of claim 1 , wherein the burst periods have a frequency of about 1 Hz to about 100 Hz.

6. The method of claim 1 , wherein the constant periods have a longer duration than the burst periods.

7. The method of claim 1 , further comprising transmitting the electrical impulse from the device through the outer skin surface to the target nerve.

8. The method of claim 1 , wherein the target nerve is a vagus nerve.

9. The method of claim 1 , wherein the duration of the pulses is about 200 microseconds.

10. The method of claim 1 , wherein the disorder is a headache.

11. A device for treating a disorder in a patient, the device comprising:
a housing having a contact surface for contacting an outer skin surface of a patient; and
an energy source coupled to the housing, the energy source being configured to generate an electrical impulse within the housing and transmit the electrical impulse through the outer skin surface to a target nerve within the patient, wherein the electrical impulse comprises burst periods and constant periods, wherein each burst period includes 4 to 10 pulses and has a duration of between 800 microseconds and 2,000 microseconds, wherein the pulses alternate between a positive voltage and a negative voltage within each burst period.

12. The device of claim 11 , further comprising an electrode coupled to the housing, wherein the energy source is configured to apply a voltage to the electrode to generate an electric field.

13. The device of claim 12 , wherein the energy source is configured to vary the voltage such that the electric field emitted by the electrode includes the burst periods and the constant periods.

14. The device of claim 12 , wherein the electric field generated during the constant periods has a magnitude of about zero.

15. The device of claim 11 , wherein the burst periods have a frequency of about 1 Hz to about 100 Hz.

16. The device of claim 11 , wherein the constant periods have a longer duration than the burst periods.

17. The device of claim 11 , wherein the energy source is configured to transmit the electrical impulse from the device through the outer skin surface to the target nerve.

18. The device of claim 11 , wherein the target nerve is a vagus nerve.

19. The device of claim 11 , wherein the duration of the pulses is about 200 microseconds.

20. The device of claim 11 , wherein the energy source is housed within the housing.

21. The device of claim 11 , wherein the disorder is a headache.

Assignees

• Electrocore Inc

Inventors

• Simon Bruce J
• Errico Joseph P
• Raffle John T

Classifications

• A61N1/36014

  External stimulators, e.g. with patch electrodes (external pacemakers A61N1/3625) · CPC title

• A61N1/36034

  specified by the stimulation parameters · CPC title

• A61N1/0472

  Structure-related aspects · CPC title

• A61N1/36053

  adapted for vagal stimulation (A61N1/36114 takes precedence) · CPC title

• A61N2/006

  for magnetic stimulation of nerve tissue · CPC title