Method for treating metastatic prostate cancer

Patent metadata

Field	Value
Publication number	US-12178795-B2
Application number	US-202318139029-A
Country	US
Kind code	B2
Filing date	Apr 25, 2023
Priority date	Jul 26, 2012
Publication date	Dec 31, 2024
Grant date	Dec 31, 2024

Abstract

A method for treating benign prostatic hyperplasia (BPH), prostatitis, and/or prostate cancer, including the step of administering an isothiocyanate functional surfactant to a patient affected by benign prostatic hyperplasia, prostatitis, and/or prostate cancer. In a preferred embodiment, the protonated form of the isothiocyanate functional surfactant is represented by the following chemical structure:

First claim

What is claimed is:

1. A method of treating metastatic prostate cancer comprising the step of:
administering a product to a patient having metastatic prostate cancer wherein the product comprises:
an isothiocyanate functional surfactant;
one or more solvents; and
at least one an additional surfactant chosen from the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

2. The method of treating metastatic prostate cancer of claim 1 , wherein the isothiocyanate functional surfactant is administered to the patient at least one of orally, intravenously, intramuscularly, intrathecally, cutaneously, subcutaneously, transdermally, sublingually, buccally, rectally, and nasally.

3. The method of treating metastatic prostate cancer of claim 1 , wherein the product is administered by applying the product to skin and the method treating metastatic prostate cancer further comprises a step of removing the product from skin of the patient a period of time after the product is applied to the skin.

4. The method of treating metastatic prostate cancer of claim 1 , wherein the at least one an additional surfactant consists of at least one non-ionic surfactant and the at least one non-ionic surfactant is chosen from a group consisting of: alcohols, alkanolamides, amine oxides, esters, ethers, silicone copolyols, cetearyl alcohol, ceteareth-20, nonoxynol-9, C12-15 pareth-9, POE(4) lauryl ether, cocamide DEA, glycol distearate, glyceryl stearate, PEG-100 stearate, sorbitan stearate, PEG-8 laurate, polyglyceryl-10 trilaurate, lauryl glucoside, octylphenoxy-polyethoxyethanol, PEG-4 laurate, polyglyceryl diisostearate, polysorbate-60, PEG-200 isostearyl palmitate, sorbitan monooleate, polysorbate-80 and combinations thereof.

5. The method of treating metastatic prostate cancer of claim 1 , wherein the at least one an additional surfactant consists of at least one anionic surfactant and the at least one anionic surfactant is chosen from a group consisting of: taurates; isethionates; alkyl and alkyl ether sulfates; succinamates; alkyl sulfonates, alkylaryl sulfonates; olefin sulfonates; alkoxy alkane sulfonates; sodium and potassium salts of fatty acids derived from natural plant or animal sources or synthetically prepared; sodium, potassium, ammonium, and alkylated ammonium salts of alkylated and acylated amino acids and peptides; alkylated sulfoacetates; alkylated sulfosuccinates; acylglyceride sulfonates, alkoxyether sulfonates; phosphoric acid esters; phospholipids, ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, sodium stearoyl isethionate, sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium lauryl sarcosinate, disodium laureth sulfosuccinate, sodium lauryl sulfoacetate, sodium cocoyl glutamate, TEA-cocoyl glutamate, TEA cocoyl alaninate, sodium cocoyl taurate, potassium cetyl phosphate and combinations thereof.

6. The method of treating metastatic prostate cancer of claim 1 , wherein the at least one an additional surfactant consists of at least one cationic surfactant and wherein the cationic surfactant is chosen from a group consisting of: alkylated quaternary ammonium salts R4NX; alkylated amino-amides (RCONH—(CH2)n)NR3X; alkylimidazolines; alkoxylated amines, cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, lauryl dimethyl ammonium bromide, stearyl dimethyl ammonium chloride, stearyl dimethyl ammonium bromide, cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, distearyl ammonium bromide, dicetyl methyl ammonium chloride, dicetyl methyl ammonium bromide, dilauryl methyl ammonium chloride, distearyl methyl ammonium chloride, distearyl methyl ammonium bromide, ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium sulfate, di(hydrogenated tallow) dimethyl ammonium chloride, di(hydrogenated tallow) dimethyl ammonium acetate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di(coconutalkyl) dimethyl ammonium chloride, di(coconutalkyl) dimethyl ammonium bromide, tallow ammonium chloride, coconut ammonium chloride, stearamidopropyl PG-imonium chloride phosphate, stearamidopropyl ethyldimonium ethosulfate, stearimidopropyldimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate, ditallowyl oxyethyl dimethyl ammonium chloride, behenamidopropyl PG dimonium chloride, dilauryl dimethyl ammonium chloride, distearly dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearamidoproyl PG-dimonium chloride phosphate, stearamidopropyl ethyldiammonium ethosulfate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearimidopropyl dimethyl cetaryl ammonium tosylate, stearamido propyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate and combinations thereof.

7. The method of treating metastatic prostate cancer of claim 1 , wherein the at least one an additional surfactant consists of at least one zwitterionic surfactant and wherein the zwitterionic surfactant is chosen from the group consisting of betaines; sultaines; hydroxysultaines, amido betaines, amidosulfo betaines, cocoamidopropyl sultaine, cocoamidopropyl hydroxyl sultaine, cocoamidopropylbetaine, coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alphacarboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine, lauryl (2-bishydroxy) carboxymethyl betaine, stearyl bis-(2-hydroxyethyl) carboxymethyl betaine, oelyl dimethyl gamma-carboxypropyl betaine, lauryl bis-(2-hydroxypropyl) alpha carboxymethyl betaine, coco dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis (2-hydroxyethyl) sulfopropyl betaine, oleyl betaine, cocamidopropyl betaine and combinations thereof.

8. The method of treating metastatic prostate cancer of claim 1 , wherein the patient is a mammal.

9. The method of treating metastatic prostate cancer of claim 8 , wherein the mammal is a human.

10. The method of treating metastatic prostate cancer of claim 1 , wherein the one or more solvents comprises a solvent chosen from the group consisting of silicone based solvents, silicon based fluids, mineral oil, vegetable oils, and squalene.

11. The method treating metastatic prostate cancer of claim 1 , wherein the product is a topical preparation selected from a group consisting of ointment, cream, emulsion, lotion and gel.

12. A method of treating metastatic prostate cancer comprising the steps of:
contact a product to a part of a human affected by metastatic prostate cancer wherein the product comprises a first surfactant or pharmaceutically acceptable salt thereof and a second surfactant to an area affected by metastatic prostate cancer wherein the first surfactant is represented by the following chemical structure:

Assignees

• The William M Yarbrough Found
• The William Yarbrough Found

Inventors

• Silver Michael E

Classifications

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61K31/195

  having an amino group · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K31/16

  Amides, e.g. hydroxamic acids · CPC title

• A61K31/198

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title