Device, method, and program for visualizing network of blood vessels of skin

Patent metadata

Field	Value
Publication number	US-12178605-B2
Application number	US-202016829546-A
Country	US
Kind code	B2
Filing date	Mar 25, 2020
Priority date	Sep 29, 2017
Publication date	Dec 31, 2024
Grant date	Dec 31, 2024

Abstract

A device of an embodiment includes: an optical mechanism; a control computation unit that controls driving of the optical mechanism, acquires a tomographic image of the skin by processing an optical interference signal from the optical system, and calculates a network of blood vessels on the basis of the tomographic image; and a display device that displays the network of blood vessels. The control computation unit expresses thicknesses of the network of blood vessels by defining, as a blood vessel radius, a radius from a set of blood vessel corresponding coordinates determined to be a blood vessel in the calculation of the network of blood vessels and within which other sets of blood vessel corresponding coordinates are present and, superimposing distinctions based on magnitudes of blood vessel radii from the respective sets of blood vessel corresponding coordinates onto the image of the network of blood vessels.

First claim

What is claimed is:

1. A blood vessel visualizing device that includes an optical system using optical coherence tomography, and visualizes a network of blood vessels of skin, the blood vessel visualizing device comprising:
an optical mechanism configured to guide light from a light source to tissue of the skin to scan the skin tissue and guide object light reflected by the skin tissue;
a control computation device configured to control an optical detection device configured for detecting the object light guided by driving of the optical mechanism, acquires a tomographic image of the skin by processing an optical interference signal from the optical mechanism, and calculates the network of blood vessels based on the acquired tomographic image of the skin; and
a display device configured to display an image of the network of blood vessels and thicknesses of the network of blood vessels superimposed onto the image of the network of blood vessels, wherein
the control computation device is configured to set spatial coordinates on the acquired tomographic image, and among the spatial coordinates, identify a plurality of blood-vessel-corresponding-coordinates in a blood vessel region included in the network of blood vessels on the acquired tomographic image of the skin, wherein optical coherence tomography intensity values of the identified plurality of blood-vessel-corresponding-coordinates on the acquired tomographic image are within a range of blood vessel determination reference values,
the control computation device is configured to set a virtual circle having one of the identified plurality of blood-vessel-corresponding-coordinates to present a center of the virtual circle and others of the identified plurality of blood-vessel-corresponding-coordinates around the one of the identified plurality of blood-vessel-corresponding-coordinates, the control computation device is configured to determine a blood vessel virtual radius of the virtual circle by increasing a radius extended from the center of the virtual circle until when or immediately before the radius of the virtual circle reaches a value at which a proportion of a number of the identified plurality of blood-vessel-corresponding-coordinates in the virtual circle to a number of the spatial coordinates in the virtual circle starts to decrease, and
the control computation device is configured to control the display device to visually display the thicknesses of the network of blood vessels by superimposing distinctions based on magnitudes of the blood vessel virtual radius respectively from the identified plurality of blood-vessel-corresponding-coordinates onto the image of the network of blood vessels.

2. The blood vessel visualizing device according to claim 1 , wherein the control computation device is configured to control the display device to visually display the thicknesses of the network of blood vessels by applying different colors respectively to the identified plurality of blood-vessel-corresponding-coordinates depending on the magnitudes of the blood vessel virtual radius.

3. A blood vessel visualizing method for visualizing a network of blood vessels of skin, the method comprising:
a tomographic image acquiring step of acquiring a tomographic image of the skin by using optical coherence tomography;
a blood-vessel-corresponding-coordinates setting spatial coordinates on the acquired tomographic image, and among the spatial coordinates, identifying step of identifying a plurality of blood-vessel-corresponding-coordinates in a blood vessel region included in the network of blood vessels on the acquired tomographic image of the skin, wherein optical coherence tomography intensity values of the identified plurality of blood-vessel-corresponding-coordinates on the acquired tomographic image are within a range of blood vessel determination reference values;
a virtual circle setting step of setting, a virtual circle having one of the identified plurality of blood-vessel-corresponding-coordinates to present a center of the virtual circle and others of the identified plurality blood-vessel-corresponding-coordinates around the one of the identified plurality of blood-vessel-corresponding-coordinates, determining a blood vessel virtual radius of the virtual circle by increasing a radius extended from the center of the virtual circle until when or immediately before the radius of the virtual circle reaches a value at which a proportion of a number of the identified plurality of blood-vessel-corresponding-coordinates in the virtual circle to a number of the spatial coordinates in the virtual circle starts to decrease; and
a thickness display step of visually displaying thicknesses of the network of blood vessels by superimposing distinctions based on magnitudes of the blood vessel virtual radius respectively from the identified plurality of blood-vessel-corresponding-coordinates onto the image of the network of blood vessels.

4. A non-transitory computer-readable storage medium storing a program for causing a computer to implement:
a function of setting spatial coordinates on a tomographic image of skin acquired by using optical coherence tomography, and among the spatial coordinates, identifying a plurality of blood-vessel-corresponding-coordinates in a blood vessel region included in a network of blood vessels on the acquired tomographic image, wherein optical coherence tomography intensity values of the identified plurality of blood-vessel-corresponding-coordinates on the acquired tomographic image are within a range of blood vessel determination reference values;
a function of setting, a virtual circle having one of the identified plurality of blood-vessel-corresponding-coordinates to present a center of the virtual circle and others of the identified plurality blood-vessel-corresponding-coordinates, determining a blood vessel virtual radius of the virtual circle by increasing a radius extended from the center of the virtual circle until when or immediately before the radius of the virtual circle reaches a value at which a proportion of as a number of the identified plurality of blood-vessel-corresponding-coordinates in the virtual circle to a number of the spatial coordinates in the virtual circle starts to decrease; and
a function of visually displaying thicknesses of the network of blood vessels by superimposing distinctions based on magnitudes of the blood vessel virtual radius respectively from the identified plurality of blood-vessel-corresponding-coordinates onto the image of the network of blood vessels.

Assignees

• Shiseido Co Ltd
• Univ Meijo

Inventors

• Hara Yusuke
• Yamashita Toyonobu
• Ninomiya Masato
• SAEKI Souichi

Classifications

• A61B2576/02

  specially adapted for a particular organ or body part · CPC title

• A61B5/743

  Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots · CPC title

• A61B5/7278

  Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals · CPC title

• A61B5/0066 Primary

  Optical coherence imaging · CPC title

• A61B2090/306

  using optical fibres · CPC title