Blood sample analyzer with sample agitating structure and blood sample agitating method

Patent metadata

Field	Value
Publication number	US-12174209-B2
Application number	US-202117170805-A
Country	US
Kind code	B2
Filing date	Feb 8, 2021
Priority date	Aug 24, 2018
Publication date	Dec 24, 2024
Grant date	Dec 24, 2024

Abstract

Disclosed in the present invention is a blood sample analyzer, including a sample conveying device, a first agitating device, a second agitating device and a controller, etc. When the first agitating device drives a sample container placed in a sample container accommodating hole to agitate a blood sample, a bottom of the sample container is kept lower than an opening of the sample container. In addition, the present invention further discloses a blood sample agitating device, a blood sample analysis method, a blood sample agitating method, and a computer storage medium.

First claim

What is claimed is:

1. A blood sample analyzer, comprising:
a sample conveying device for conveying a sample rack loaded with a first sample container and/or a second sample container;
a carrying device, wherein when the sample conveying device conveys the sample rack to a predetermined position, the carrying device is configured to carry the first sample container on the sample rack from the predetermined position to an accommodating hole of a first agitating device;
the first agitating device having the accommodating hole for placing the first sample container, the first agitating device being capable of driving the first sample container containing a small-volume blood sample and placed in the accommodating hole to agitate the small-volume blood sample;
a second agitating device capable of picking up the sample rack or the second sample container on the sample rack, and driving the second sample container containing a common-volume blood sample to agitate the common-volume blood sample; and
a controller configured to communicate with the sample conveying device, the first agitating device and the second agitating device, and control the sample conveying device, the first agitating device and the second agitating device;
wherein when the first agitating device drives the first sample container placed in the accommodating hole to agitate the small-volume blood sample, a bottom of the first sample container is kept lower than an opening of the first sample container,
wherein the first agitating device further comprises:
an accommodating seat, a top part of which is provided with the accommodating hole; and
a driving device for driving the accommodating seat to rotate, thereby driving the first sample container in the accommodating hole to rotate, so as to agitate the small-volume blood sample,
wherein the accommodating hole is arranged eccentrically relative to the accommodating seat, so that the first sample container in the accommodating hole is capable of being rotated eccentrically.

2. The blood sample analyzer according to claim 1 , wherein:
the carrying device is a part of the second agitating device; and
the second agitating device is capable of carrying, via the carrying device, the first sample container on the sample rack, which is conveyed by the sample conveying device to an agitating position, to the accommodating hole of the first agitating device, wherein the agitating position and the predetermined position are same.

3. The blood sample analyzer according to claim 1 , wherein the driving device is a first motor.

4. The blood sample analyzer according to claim 1 , wherein the driving device is a first magnetic driving device, and
a lower part of the accommodating seat is provided with a plurality of first magnets, and the first magnetic driving device comprises a plurality of second electromagnets; wherein an interaction between the plurality of second electromagnets and the plurality of first magnets causes the accommodating seat to rotate.

5. The blood sample analyzer according to claim 1 , wherein the first agitating device further comprises:
an accommodating seat provided with the accommodating hole for placing the first sample container, wherein a lower part of the accommodating seat is provided with a first magnet; and
a vibration driving device which is a second magnetic driving device comprising a second magnet for driving the accommodating seat to vibrate within a predetermined range, thereby driving the first sample container in the accommodating hole to vibrate to agitate the small-volume blood sample under a condition that the bottom of the first sample container is kept lower than the opening of the first sample container,
wherein an interaction between the second magnet and the first magnet causes the accommodating seat to vibrate within the predetermined range.

6. The blood sample analyzer according to claim 5 , wherein:
the first magnet comprises a first permanent magnet and a second permanent magnet, and magnetic poles of the first permanent magnet and the second permanent magnet are provided in same magnetization direction; and
the second magnet comprises a first electromagnet and a second electromagnet;
wherein the lower part of the accommodating seat is located between the first electromagnet and the second electromagnet.

7. The blood sample analyzer according to claim 1 , further comprising:
a sample receiving assembly, comprising a receiving cover and a receiving hole, wherein the sample receiving assembly is configured to receive the first sample container or the second sample container, such that the sample conveying device conveys the first sample container or the second sample container placed in the receiving hole.

8. The blood sample analyzer according to claim 7 , wherein:
the controller is further configured to determine, according to an input of a user, whether a current feeding mode is a first feeding mode or a second feeding mode;
when the current feeding mode is determined to be the first feeding mode, the controller controls the sample conveying device to convey the sample rack loaded with the first and/or second sample container; and
when the current feeding mode is determined to be the second feeding mode, the controller controls the sample receiving assembly to convey the first or second sample container individually.

9. The blood sample analyzer according to claim 1 , further comprising:
a measurement mode setting device for setting a first measurement mode and a second measurement mode;
wherein the controller executes the following operations according to a setting of the measurement mode setting device:
(1) determining whether the first measurement mode or the second measurement mode is set;
(2) when the first measurement mode is determined to be set, controlling the first agitating device to agitate the small-volume blood sample in the first sample container; and
(3) when the second measurement mode is determined to be set, controlling the second agitating device to pick up the second sample container on the sample rack for agitating.

10. The blood sample analyzer according to claim 9 , wherein the small-volume blood sample in the first sample container is pre-diluted, and
wherein, the measurement mode setting device is further configured for setting a third measurement mode; and
when the third measurement mode is determined to be set, the controller controls the first agitating device to perform agitation on the first sample container containing the pre-diluted small-volume blood sample.

11. The blood sample analyzer according to claim 1 , wherein the controller is capable of controlling agitating parameters of the first agitating device based on shape and size of the first sample container, volume and source of the small-volume blood sample.

12. A blood sample analysis method, comprising:
providing a blood sample analyzer including a first agitating device, a second agitating device, an aspirator, a tester and a controller;
the method further comprises:
measurement mode determination step: determining whether a current measurement mode is a first measurement mode or a second measurement mode by the controller;
first test sample preparation step: when the current measurement mode is determined to be the first measurement mode, agitating a blood sample in a sample container by the first agitating device, and aspirating, by the aspirator, a first sampling amount of the agitated blood sample to prepare a first test sample;
second test sample preparation step: when the current measurement mode is determined to be the second measurement mode, agitating the blood sample in the samp

Assignees

• Shenzhen Mindray Biomedical Electronics Co Ltd
• Shenzhen Mindray Scient Co Ltd

Inventors

• Hu Lijian
• Xie Zixian
• Liu Yuanxing

Classifications

• G01N2035/00524

  Mixing by agitating sample carrier · CPC title

• G01N1/38

  Diluting, dispersing or mixing samples · CPC title

• B01F35/422

  having a jaw-type or finger-type shape · CPC title

• B01F31/201

  Holders therefor · CPC title

• B01F31/10

  with a mixing receptacle rotating alternately in opposite directions · CPC title