Emulsion production microfluidic device

Patent metadata

Field	Value
Publication number	US-12172155-B2
Application number	US-202017602178-A
Country	US
Kind code	B2
Filing date	Apr 8, 2020
Priority date	Apr 12, 2019
Publication date	Dec 24, 2024
Grant date	Dec 24, 2024

Abstract

Disclosed is an emulsion production microfluidic device which includes: a first channel, including an entry port configured to inject a phase to be dispersed, a second channel, including an entry port configured to inject a continuous phase and an emulsion exit port, and at least one array of microchannels, a height of each of the microchannels being smaller than a height of the first channel; the second channel includes a first part connected to the outlet of each microchannel and at least a second part along the first part, the first part being between the array of microchannels and the second part, the first part having a height greater that the height of each microchannel, and the second part having a height greater than the height of the first part.

First claim

The invention claimed is:

1. An emulsion production microfluidic device which comprises:
A first channel, comprising an entry port configured to inject a phase to be dispersed into the first channel,
A second channel, comprising an entry port configured to inject a continuous phase into this second channel, and an emulsion exit port configured to extract an emulsion from the device, and
At least one array of microchannels, arranged side by side, each microchannel comprising an inlet from the first channel, and an outlet to the second channel, a height h 0 of each of the microchannels being smaller than a height h 1 of the first channel,

wherein the second channel comprises a first part connected to the outlet of each microchannel and at least a second part along the first part, the first part being between the array of microchannels and the second part, the first part having a height h 2 a greater that the height h 0 of each microchannel, and the second part having a height h 2 b greater than the height h 2 a of the first part.

2. Device according to claim 1 , wherein at least one microchannel comprises at least a part with a constant width W.

3. Device according to claim 2 , wherein the width W of at least a part of a microchannel, is comprised between 0.01 to 10,000 times the height h 0 .

4. Device according to claim 3 , wherein at least one microchannel comprises a flared part.

5. Device according to claim 3 , wherein the array of microchannels comprises a part which is common to at least two microchannels at the outlet location.

6. Device according to claim 3 , wherein the array of microchannels comprises at least 10 microchannels.

7. Device according to claim 2 , wherein at least one microchannel comprises a flared part.

8. Device according to claim 2 , wherein the array of microchannels comprises a part which is common to at least two microchannels at the outlet location.

9. Device according to claim 2 , wherein the array of microchannels comprises at least 10 microchannels.

10. Device according to claim 1 , wherein at least one microchannel comprises a flared part.

11. Device according to claim 10 , wherein the array of microchannels comprises a part which is common to at least two microchannels at the outlet location.

12. Device according to claim 10 , wherein the array of microchannels comprises at least 10 microchannels.

13. Device according to claim 1 , wherein the array of microchannels comprises a part which is common to at least two microchannels at the outlet location.

14. Device according to claim 1 , wherein the array of microchannels comprises at least 10 microchannels.

15. Device according to claim 1 , wherein the height h 2 a of the first part of the second channel is from 2 to 100 times greater than the height h 0 of a microchannel.

16. Device according to claim 1 , wherein the height h 2 b of the second part of the second channel is from 2 to 100 times greater than the height h 2 a of the first part of the second channel.

17. Device according to claim 1 , wherein the height h 1 of the first channel is from 2 to 1000 times greater than the height h 0 of a microchannel.

18. Device according to claim 1 , wherein the first channel has a width comprised between 1 to 100 times the height h 1 .

19. Device according to, claim 1 , wherein the second channel has a width comprised between 1 to 100 times the height h 2 b of the second part.

20. Device according to, claim 1 , wherein a hydrophilic molecule is adsorbed or grafted in at least part of the surfaces of the first channel, and/or the second channel, and/or the microchannel, to make the surface hydrophilic, or a hydrophobic molecule is adsorbed or grafted in at least part of the surfaces of the first channel, and/or the second channel, and/or the microchannel, to make the surface hydrophobic.

Assignees

• Paris Sciences Et Lettres
• Centre Nat Rech Scient
• Ecole Superieure Physique & Chimie Ind Ville De Paris

Inventors

• Bremond Nicolas
• Bibette Jérôme
• Bazin Gwénaëlle

Classifications

• B01L2300/165

  Specific details about hydrophobic, oleophobic surfaces · CPC title

• B01L2300/0867

  Multiple inlets and one sample wells, e.g. mixing, dilution · CPC title

• B01L2300/0819

  Microarrays; Biochips · CPC title

• B01F23/4105

  Methods of emulsifying · CPC title

• B01F33/30351

  using hydrophilic/hydrophobic surfaces · CPC title