Method for producing a light-curable resin composition

Patent metadata

Field	Value
Publication number	US-12140656-B2
Application number	US-202118026740-A
Country	US
Kind code	B2
Filing date	Sep 15, 2021
Priority date	Sep 23, 2020
Publication date	Nov 12, 2024
Grant date	Nov 12, 2024

Abstract

Method for producing a light-curable resin composition capable of producing a magnetic resonance imaging-signal, in particular for the lithography-based additive production of magnetic resonance imaging phantoms, the method comprising at least the following steps: providing particles at least partially filled with a magnetic resonance imaging-signal producing liquid, and mixing the at least partially filled particles with a light-curable resin.

First claim

The invention claimed is:

1. A method for producing a light-curable resin composition capable of producing a magnetic resonance imaging-signal, the method comprising:
providing particles at least partially filled with a magnetic resonance imaging-signal producing liquid; and
mixing the at least partially filled particles with a light-curable resin.

2. The method according to claim 1 , wherein the particles are provided as porous particles and are mixed with a magnetic resonance imaging-signal producing liquid thereby obtaining particles at least partially filled with the liquid.

3. The method according to claim 1 , wherein the particles are provided as hollow particles that are filled at least partially with a magnetic resonance imaging-signal producing liquid.

4. The method according to claim 1 , wherein the particles are made of an acrylic resin.

5. The method according to claim 1 , wherein the spherical particles have a mean diameter of 5 μm to 50 μm.

6. The method according to claim 1 , wherein the particles are filled to 25 wt.-% to 75 wt.-% of the total absorption capacity of the particles.

7. The method according to claim 1 , wherein the particles have an oil absorption capacity of 100-180 ml/100 gr.

8. The method according to claim 1 , wherein the particles have a specific surface area of 60-100 m 2 /g.

9. The method according to claim 1 , wherein water or a lipid, in particular a triglyceride is used as said magnetic resonance imaging-signal producing liquid, wherein the magnetic resonance imaging-signal producing liquid is preferably selected from one or more of the group comprised of seed oil, sunflower oil, paraffin oil and silicon oil.

10. The method according to claim 1 , wherein the amounts of particles at least partially filled with the liquid and of the light-curable resin are chosen so as to obtain a weight ratio of 3:10-10:10.

11. The method according to claim 1 , further comprising the step of subjecting the mixture of the at least partially filled particles with the light-curable resin to a vacuum.

12. A magnetic resonance imaging-signal producing, light-curable resin composition obtained by a method according to claim 1 .

13. A magnetic resonance imaging-signal producing, light-curable resin composition comprising a mixture of a light-curable resin with particles that are at least partially filled with a magnetic resonance imaging-signal producing liquid.

14. A magnetic resonance imaging phantom produced by curing a magnetic resonance imaging-signal producing, light-curable resin composition according to claim 13 .

15. A method of producing a magnetic resonance imaging phantom, comprising the steps of:
providing a mixture of a light-curable resin with particles that are at least partially filled with a magnetic resonance imaging-signal producing liquid, in particular produced by a method according to claim 1 ; and
building the phantom layer-by-layer by means of an additive manufacturing process, the additive manufacturing process comprising:
a) applying a layer of the mixture on a material carrier or on the partly built phantom,
b) exposing the layer to an electromagnetic radiation in order to position-selectively cure said layer according to a desired layer geometry, and
c) repeating steps a) and b) until the phantom is complete.

Assignees

• Univ Wien Med

Inventors

• Rausch Ivo
• Valladares Alejandra
• Unger Ewald
• Berg Andreas
• Rosenbüchler Peter

Classifications

• C08K2201/006

  Additives being defined by their surface area · CPC title

• C08K2201/003

  Additives being defined by their diameter · CPC title

• C08K9/10

  Encapsulated ingredients · CPC title

• C08K7/16

  Solid spheres · CPC title

• C08J2333/08

  Homopolymers or copolymers of acrylic acid esters · CPC title