Apparatus and method for monitoring nitric oxide delivery

Patent metadata

Field	Value
Publication number	US-12138396-B2
Application number	US-201916537955-A
Country	US
Kind code	B2
Filing date	Aug 12, 2019
Priority date	Nov 7, 2011
Publication date	Nov 12, 2024
Grant date	Nov 12, 2024

Abstract

Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.

First claim

What is claimed is:

1. An apparatus to deliver a therapeutic gas to a patient, the apparatus comprising:
a therapeutic gas injector module comprising:
a first inlet in fluid communication with a therapeutic gas supply providing a flow of nitric oxide at a therapeutic gas supply concentration;
a second inlet in fluid communication with a breathing gas delivery system providing a flow of a breathing gas; and
an outlet to supply a combined flow of the breathing gas and the therapeutic gas to the patient;

a control circuit including a first flow sensor to measure the flow of the breathing gas from the breathing gas delivery system, wherein the control circuit comprises a backup mode in which a known constant flow of the therapeutic gas is independent of a breathing gas flow rate, wherein when the control circuit is in the backup mode, it is operable to deliver the known constant flow of the therapeutic gas and estimate a backup dose based on the known constant flow of the therapeutic gas and the measured flow of the breathing gas, wherein the control circuit is operable to store a breathing gas flow rate history; and
a display, in communication with the control circuit, that provides the estimate of the backup dose,
wherein the display is further configured to display the breathing gas flow rate history, wherein the breathing gas flow rate history comprises a peak and/or average breathing gas flow rate for a period of time;
wherein the display is further configured to display a chart and/or graphic comprising a plurality of breathing gas flow rates and a predicted dose for each of the plurality of breathing gas flow rates.

2. The apparatus of claim 1 , wherein the control circuit assigns a set flow rate based on the constant flow of the therapeutic gas.

3. The apparatus of claim 1 , wherein the display also provides a visual and/or numeric indication of the measured flow of the breathing gas.

4. The apparatus of claim 3 , wherein the visual and/or numeric indication of the measured flow of the breathing gas includes one or more of volumetric flow rate, tidal volume, and/or minute ventilation.

5. The apparatus of claim 3 , wherein the visual and/or numeric indication is an icon or graphic on the display that provides a visual and/or numeric indication of the measured flow of the breathing gas.

6. The apparatus of claim 3 , wherein the measured flow of the breathing gas is one or more of an average flow rate, an instantaneous flow rate, a peak flow rate and/or a minimum measured flow rate.

7. The apparatus of claim 1 , wherein the breathing gas delivery system comprises a ventilation apparatus.

8. The apparatus of claim 7 , wherein the ventilation apparatus comprises a user input operable to set a certain flow rate or pressure control to achieve a desired therapeutic gas concentration for the backup mode.

9. A method of monitoring delivery of a therapeutic gas to a patient comprising:
providing a flow of a breathing gas;
providing a flow of the therapeutic gas comprising nitric oxide;
measuring the flow of the breathing gas to obtain a measured flow of the breathing gas;
obtaining a known constant flow of the therapeutic gas;
receiving from a user a desired delivery concentration of the therapeutic gas to be delivered to the patient;
delivering the breathing gas and the therapeutic gas to the patient;
storing a breathing gas flow rate history;
estimating, via a backup mode in which the known constant flow of the therapeutic gas is independent of a breathing gas flow rate, a backup dose of nitric oxide based on the measured flow of breathing gas and the known constant flow of therapeutic gas;
displaying the estimated backup dose; and
displaying the breathing gas flow rate history, wherein the breathing gas flow rate history comprises a peak and/or average breathing gas flow rate for a period of time;
displaying a chart and/or graphic comprising a plurality of breathing gas flow rates and a predicted dose for each of the plurality of breathing gas flow rates.

10. The method of claim 9 , wherein the known constant flow of the therapeutic gas is a set flow rate.

11. The method of claim 9 , further comprising displaying the measured flow of the breathing gas.

12. The method of claim 11 , wherein displaying the measured flow of the breathing gas includes displaying one or more of volumetric flow rate, tidal volume, and/or minute ventilation.

13. The method of claim 11 , wherein the measured flow of the breathing gas is one or more of an average flow rate, an instantaneous flow rate, a peak flow rate and/or a minimum measured flow rate.

14. The apparatus of claim 1 , wherein the control circuit is further configured to store an estimated backup dose history and the display is configured to display the estimated backup dose history for a period of time.

15. The method of claim 9 , the method further comprising storing an estimated backup dose history and displaying the estimated backup dose history for a period of time.

Assignees

• Mallinckrodt Pharmaceuticals Ireland Ltd

Inventors

• Tolmie Craig R
• Schnitman Robert
• Medicis Joseph J
• Potenziano Jim
• Acker Jaron
• Schmidt Jeffrey

Classifications

• A61M2205/583

  by visual feedback · CPC title

• A61M2205/581

  by audible feedback · CPC title

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M2205/18

  with alarm · CPC title