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US-2020230051-A1 · Jul 23, 2020 · US
Method of increasing cell adhesion with palygorskite
US12138317B1 · US · B1
| Field | Value |
|---|---|
| Publication number | US-12138317-B1 |
| Application number | US-202418777706-A |
| Country | US |
| Kind code | B1 |
| Filing date | Jul 19, 2024 |
| Priority date | Aug 18, 2017 |
| Publication date | Nov 12, 2024 |
| Grant date | Nov 12, 2024 |
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Abstract
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A method for enhancing or restoring adhesion to cells that have partially or completely loss the ability to adhere to a substrate or other cells using nanosized clay crystallites.
First claim
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The invention claimed is: 1. A method of increasing cell adhesion, comprising preparing a composition by: sonicating a mixture of nanosized smectite and saline to form the composition, wherein the composition consists of saline and the nanosized smectite, and contacting Raji cells with the composition, wherein the nanosized smectite is palygorskite crystallites having a particle size of 30-75 nm and a cation exchange capacity (CEC) value of about 20 meq/100 g, wherein the contacting results in an increase in adhesion force of the Raji cells to a target substrate of about 200%, compared to a same method but without contacting the Raji cells with the composition, wherein the target substrate is an extracellular matrix (ECM) comprising fibronectin, and wherein the adhesion force is measured between the fibronectin and the Raji cells by atomic force microscopy. 2. The method of claim 1 , wherein the contacting comprises exposing the Raji cells to a concentration of no more than 10 mg/ml of the nanosized smectite in the saline.
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Classifications
Inorganic compounds · CPC title
Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells · CPC title
from inanimate materials (carbon A61K33/44) · CPC title
Iron; Compounds thereof · CPC title
specific for metastasis · CPC title
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- What does patent US12138317B1 cover?
- A method for enhancing or restoring adhesion to cells that have partially or completely loss the ability to adhere to a substrate or other cells using nanosized clay crystallites.
- Who is the assignee on this patent?
- Univ King Fahd Pet & Minerals
- What technology area does this patent fall under?
- Primary CPC classification C01B33/38. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 12 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).