Ultrasound localization system with advanced biopsy site markers

Patent metadata

Field	Value
Publication number	US-12133695-B2
Application number	US-202117524590-A
Country	US
Kind code	B2
Filing date	Nov 11, 2021
Priority date	Dec 11, 2017
Publication date	Nov 5, 2024
Grant date	Nov 5, 2024

Abstract

Disclosed biopsy markers are adapted to serve as localization markers during a surgical procedure. Adaptation includes incorporation of materials detectable under ultrasound during surgery, as well as features for co-registration with image guidance or other real-time imaging technologies during surgery. Such biopsy markers, when used as localization markers, improve patient comfort and reduce challenges in surgical coordination and surgery time. Additional disclosed biopsy markers are adapted to serve as monitoring and/or detection apparatuses. Localization of an implanted marker may be done with ultrasound technology. Ultrasound image data is analyzed to identify the implanted marker. A distance to the marker or a lesion may be determined and displayed. The determined distance may be a distance between the ultrasound probe and the marker or lesion, a distance between the marker or lesion and an incision instrument, and/or a distance between the ultrasound probe and the incision instrument.

First claim

What is claimed is:

1. A method for localization of an implanted marker with ultrasound technology, the method comprising:
providing a marker implanted proximate a lesion within an interior of a patient, the marker having a marker localization transceiver and at least one detector;
emitting ultrasonic sound waves from an ultrasonic transducer of an ultrasound probe;
detecting reflected ultrasonic sound waves by the ultrasonic transducer, wherein the reflected ultrasonic sound waves include at least a portion of the emitted ultrasonic sound waves after being reflected from the marker;
generating an image from image data from the reflected ultrasonic sound waves;
receiving a signal containing marker data and lesion data from the marker localization transceiver;
processing, by a processor, the signal received from the marker localization transceiver to determine (1) a location of the marker based on the marker data, and (2) changes regarding the lesion based on the lesion data;
displaying, on a display operatively connected to the processor, the image with (1) the location of the marker, and (2) the changes regarding the lesion; and
based at least in part on the location of the marker, emitting an audible sound, wherein the audible sound is based on how close the marker is to a center of a field of view of the image displayed on the display.

2. The method of claim 1 , further comprising based on the location of the marker, determining, by the processor, a distance to at least one of the marker or the lesion.

3. The method of claim 2 , wherein the distance to the at least one of the marker or the lesion is based on at least one of a location of the ultrasound probe or an orientation of the ultrasound probe.

4. The method of claim 3 , further comprising:
receiving a signal from a probe localization transceiver, wherein the probe localization transceiver is attached to the ultrasound probe; and
processing, by the processor, the signal received from the probe localization transceiver to determine the at least one of the location of the ultrasound probe or the orientation of the ultrasound probe.

5. The method of claim 2 , wherein the distance to the at least one of the marker or the lesion is based on at least one of a location of an incision instrument or an orientation of the incision instrument.

6. The method of claim 5 , further comprising:
receiving a signal from an instrument localization transceiver, wherein the instrument localization transceiver is attached to the incision instrument; and
processing, by the processor, the signal received from the instrument localization transceiver to determine the at least one of the location of the incision instrument or the orientation of the incision instrument.

7. The method of claim 1 , wherein the marker includes a receiver configured to convert wave energy into electrical energy, and the method further comprises controlling the marker localization transceiver to send the signal based on wave energy.

8. The method of claim 7 , further comprising activating the marker localization transceiver by the emitted ultrasonic sound waves.

9. The method of claim 7 , further comprising powering the marker localization transceiver with an inductive power supply configured to generate an electromagnetic wave.

10. The method of claim 1 , wherein the signal from the marker localization transceiver includes a unique identifier, the method further comprising displaying the unique identifier on the display.

11. The method of claim 1 , wherein the signal from the marker localization transceiver is a radio frequency identification signal.

12. A system for ultrasound localization, the system comprising:
a marker comprising a marker localization transceiver configured to emit a signal containing marker data and lesion data, and at least one detector, wherein the marker is configured to be implanted proximate a lesion within an interior of a patient;
an ultrasound probe comprising an ultrasonic transducer, the ultrasonic transducer configured to emit ultrasonic sound waves and detect reflected ultrasonic sound waves, wherein the reflected ultrasonic sound waves include at least a portion of the emitted ultrasonic sound waves after being reflected from the marker;
a display;
at least one processor operatively connected to the marker, the ultrasound probe, and the display; and
memory, operatively connected to the at least one processor, storing instructions that when executed by the at least one processor perform a set of operations comprising:
generating an image from image data from the reflected ultrasonic sound waves;
receiving a signal containing marker data and lesion data from the marker localization transceiver;
processing the signal received from the marker localization transceiver to determine (1) a location of the marker based on the marker data, and (2) changes regarding the lesion based on the lesion data;
displaying on the display the image with (1) the location of the marker, and (2) the changes regarding the lesion; and
based at least in part on the location of the marker, emitting an audible sound, wherein the audible sound is based on how close the marker is to a center of a field of view of the image displayed on the display.

13. The system of claim 12 , wherein the set of operations that the at least one processor performs further comprises based at least in part on the location of the marker, determining, a distance to at least one of the marker or the lesion.

14. The system of claim 13 , wherein the distance to the at least one of the marker or the lesion is based on at least one of a location of the ultrasound probe or an orientation of the ultrasound probe.

15. The system of claim 14 , wherein the ultrasound probe further comprises a probe localization transceiver, wherein the probe localization transceiver transmits data to indicate the at least one of the location of the ultrasound probe or the orientation of the ultrasound probe.

16. The system of claim 13 , further comprising an incision instrument, wherein the distance to the at least one of the marker or the lesion is based on at least one of a location of the incision instrument or an orientation of the incision instrument.

17. The system of claim 16 , wherein the incision instrument comprises an instrument localization transceiver, wherein the instrument localization transceiver transmits data to indicate the at least one of the location of the incision instrument or the orientation of the incision instrument.

18. The system of claim 12 , wherein the marker includes a receiver configured to convert wave energy into electrical energy, and the marker localization transceiver is controllable to send the signal based on wave energy.

19. The system of claim 18 , wherein the marker localization transceiver is configured to be activated by the emitted ultrasonic sound waves.

20. The system of claim 18 , further comprising an inductive power supply configured to generate an electromagnetic wave and power the marker localization transceiver.

21. The system of claim 12 , wherein the signal from the marker localization transceiver includes a unique identifier, and the unique identifier is displayed on the display.

22. The system of claim 12 , wherein the signal from the marker localization transceiver is a radio frequency identification signal.

Assignees

• Hologic Inc

Inventors

• Laviola John
• St Pierre Shawn
• Stellmach Brian
• Fontaine Lori
• Stand Iii Joseph A
• Alvarez Estefania
• Grantz Stephen
• Lyman Michelle Dawn
• Butler Shannon Marie
• Mathis Yuliya

Classifications

• A61B2018/00595

  Cauterization · CPC title

• A61B17/3211

  Surgical scalpels, knives; Accessories therefor · CPC title

• A61B8/481

  involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream · CPC title

• A61B2090/395

  with marking agent for marking skin or other tissue · CPC title

• A61B2090/3904

  specially adapted for marking specified tissue · CPC title