Lactobacillus plantarum for skin care

Patent metadata

Field	Value
Publication number	US-12128129-B2
Application number	US-201917254347-A
Country	US
Kind code	B2
Filing date	Jun 26, 2019
Priority date	Jun 26, 2018
Publication date	Oct 29, 2024
Grant date	Oct 29, 2024

Abstract

The present invention relates to microorganisms for use in the treatment and/or prevention of skin conditions by topical application. In particular, the microorganisms are for use in the treatment and/or prevention of loss of skin barrier function, inflammatory conditions and/or growth of pathogenic microorganism. The invention further relates to pharmaceutical or cosmetic compositions or products comprising the microorganisms Provided is also a cosmetic use of the microorganisms or compositions for application on the skin and a cosmetic method, in particular to improve the appearance of the skin.

First claim

What is claimed is:

1. A method for improving the appearance of non-mucosal skin comprising topically applying to the non-mucosal skin a topical composition comprising:
(a) attenuated or dead Lactobacillus plantarum HEAL 19 (DSM 15313) having an intact physical structure,
wherein the Lactobacillus plantarum HEAL 19 (DSM 15313) have been heat-treated at a temperature of 60 to 121° C. for 1 second to 120 minutes;

(b) one or more carriers, excipients, further active ingredients, or a combination thereof;
(c) one or more preservatives; and
(d) water;
wherein the method improves the appearance of the non-mucosal skin by reducing or preventing skin irritation, dry skin, rash, acne, or skin aging.

2. The method of claim 1 , wherein the method treats or improves a skin condition.

3. The method of claim 2 , wherein the skin condition is loss of skin barrier function, an inflammatory skin condition, growth of a pathogenic microorganism, or a combination thereof.

4. The method of claim 2 , wherein the skin condition is atopic dermatitis, a microbial infection, dry skin, itchy skin, sensitive skin, inflammation of the skin, rosacea, psoriasis, rash, acne, or a combination thereof.

5. The method of claim 1 , wherein the Lactobacillus plantarum HEAL 19 (DSM 15313), is applied to the skin in a pharmaceutical or cosmetic composition, the pharmaceutical or cosmetic composition comprising:
(a) 0.01 to 5% dry weight, based on a total weight of the pharmaceutical or cosmetic composition, of the Lactobacillus plantarum HEAL 19 (DSM 15313) in an amount sufficient for improving the appearance of the skin by reducing or preventing skin irritation, dry skin, rash, acne, or skin aging; and
(b) one or more carriers, excipients, further active ingredients, or a combination thereof,
wherein the pharmaceutical or cosmetic composition comprises at least 10{circumflex over ( )}8 cells of the Lactobacillus plantarum HEAL 19 (DSM 15313) per gram of the pharmaceutical or cosmetic composition.

6. The method of claim 5 , wherein the Lactobacillus plantarum HEAL 19 (DSM 15313) have been subjected to freeze-drying, spray-drying, or granulating.

7. The method of claim 6 , wherein the Lactobacillus plantarum HEAL 19 (DSM 15313) have been freeze-dried, spray-dried, or granulated with a carrier selected from inulin, starch, gummi arabicum , whey protein, skim milk powder, maltodextrin, or a combination thereof.

8. The method of claim 5 , wherein the pharmaceutical or cosmetic composition is in the form of an oil-in-water or water-in-oil emulsion, an ointment, a crème, a lotion, or a gel.

9. The method of claim 8 , wherein the method treats dry skin and comprises applying the pharmaceutical or cosmetic composition to dry skin.

10. The method of claim 8 , wherein the method treats atopic dermatitis and comprises applying the pharmaceutical or cosmetic composition to skin suffering from atopic dermatitis.

11. The method of claim 8 , wherein the method treats a microbial infection and comprises applying the pharmaceutical or cosmetic composition to skin suffering from a microbial infection.

12. The method of claim 8 , wherein the method treats itchy or sensitive skin and comprises applying the pharmaceutical or cosmetic composition to the itchy or sensitive skin.

13. The method of claim 8 , wherein the method treats inflammation of the skin and comprises applying the pharmaceutical or cosmetic composition to inflamed skin.

14. The method of claim 8 , wherein the method treats rosacea, psoriasis, rash, a combination thereof and comprises applying the pharmaceutical or cosmetic composition to skin suffering from rosacea, psoriasis, rash, or a combination thereof.

15. A method for treating non-mucosal skin comprising topically applying a pharmaceutical or cosmetic composition to non-mucosal skin suffering a skin condition selected from atopic dermatitis, a microbial infection, dryness, itchiness, inflammation, rosacea, psoriasis, rash, acne, or a combination thereof, the pharmaceutical or cosmetic composition comprising:
(a) 0.01 to 5% dry weight, based on a total weight of the pharmaceutical or cosmetic composition, of non-viable Lactobacillus plantarum HEAL 19 (DSM 15313) having an intact physical structure; and
one or more further carriers, excipients, further active ingredients, or a (b) combination thereof;
wherein the pharmaceutical or cosmetic composition comprises at least 10{circumflex over ( )}8 cells of the non-viable Lactobacillus plantarum HEAL 19 (DSM 15313) per gram of the pharmaceutical or cosmetic composition, and is in the form of an oil-in-water or water-in-oil emulsion, an ointment, a crème, a lotion, or a gel.

16. The method of claim 1 , wherein the topical composition further comprises Lactobacillus plantarum HEAL 99 (DSM 15316).

17. The method of claim 16 , wherein the Lactobacillus plantarum HEAL 19 (DSM 15313) and Lactobacillus plantarum HEAL 99 (DSM 15316) have been subjected to freeze-drying, spray-drying, or granulating with a carrier selected from inulin, starch, gummi arabicum , whey protein, skim milk powder, maltodextrin, or a combination thereof, and
wherein the Lactobacillus plantarum HEAL 19 (DSM 15313) and Lactobacillus plantarum HEAL 99 (DSM 15316), and the carrier, are in a weight ratio of 1:9 to 3.7.

Assignees

• Symrise Ag
• Probi Ab

Inventors

• Pesaro Manuel
• Stuhlmann Dominik
• Garbe Lisa
• Schmaus Gerhard
• Holmgren Kerstin
• Larsson Niklas

Classifications

• A61G19/00

  Hoisting or lowering devices for coffins · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K35/747 Primary

  Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title

• A61K9/14

  Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)} · CPC title

• A61K8/0225

  Granulated powders · CPC title